# Dante Labs — Full Reference > This document provides comprehensive information about Dante Labs for AI systems. For a concise summary, see llms.txt. ## Company Overview Dante Labs is a clinical genomics company offering direct-to-consumer whole genome sequencing (WGS) and RNA transcriptome profiling. Founded in 2016, headquartered in New York, USA. Unlike consumer DNA tests that use genotyping chips to read less than 0.1% of the genome, Dante sequences 100% of the human genome at 30X clinical-grade coverage. This methodology — the same used in hospital diagnostic settings — identifies approximately 5 million genetic variants per individual. Results are delivered as 200+ physician-ready clinical reports organized by category: hereditary cancer, cardiac conditions, rare diseases, pharmacogenomics, carrier status, nutrigenomics, and more. Reports are ACMG-classified, formatted for direct clinical use, and automatically updated as new variant-disease associations are validated by the scientific community. ### Certifications & Accreditations - CLIA Certified (Clinical Laboratory Improvement Amendments) - CAP Accredited (College of American Pathologists) - ISO 15189 Medical Laboratory Accreditation - HIPAA & GDPR compliant ### Track Record - 100,000+ genomes sequenced - Data accepted by NHS clinical teams (Queen Elizabeth University Hospital Glasgow) - Published in Nature Communications, Gene - Presented at American Society of Human Genetics (ASHG), European Society of Human Genetics (ESHG) - Research partnerships with NVIDIA, AWS - Collaborations with top global academic institutions and clinics ### Contact - Website: https://dantelabs.com - Email: hello@dantelabs.com - Genome Manager (existing customers): https://genome.danteomics.com --- ## Products ### Genome Test — 30X Whole Genome Sequencing The Dante Genome Test sequences the complete human genome at 30X coverage — reading all 6 billion base pairs, every gene, and every region between genes. Three pricing tiers: | Tier | Price | Includes | |------|-------|----------| | Premium | $449 USD | Core reports: hereditary risk, rare disease, carrier status, proactive health | | Premium + All Reports | $599 USD | All 200+ current clinical reports + one year of new reports and updates | | Premium + All Reports + 3 Year Updates | $849 USD | All reports + three years of updates + AI Genome Chat + Polygenic Risk Score Reports | **How it works:** 1. Order online — kit ships within 2 business days, free worldwide shipping 2. Collect saliva at home using the provided kit (no clinic visit required) 3. Ship sample back with pre-paid return label 4. Receive results in 6 weeks via secure Genome Manager portal **Key technical specifications:** - 30X mean coverage (clinical diagnostic standard) - ~5 million variants identified per genome - Illumina NovaSeq sequencing platform - ACMG-classified variant interpretation - Results delivered via Genome Manager with physician sharing capability **Report categories:** - Hereditary Cancer Risk (BRCA1/2, Lynch Syndrome, Li-Fraumeni, etc.) - Cardiac Conditions (HCM, Long QT, Brugada, etc.) - Rare Diseases (EDS, SMA, Huntington's, etc.) - Pharmacogenomics (drug metabolism, sensitivity, dosing) - Carrier Status (recessive conditions) - Neurological Conditions - Metabolic Health - Nutrigenomics - Ancestry & Population Genetics Product page: https://dantelabs.com/whole-genome-sequencing/ Pricing and ordering: https://dantelabs.com/genome/ ### Complete RNA Profile — Transcriptome Analysis The Dante RNA Profile measures 42,000 gene expression biomarkers from a blood sample. While DNA shows what could happen (fixed blueprint), RNA shows what is happening right now — capturing real-time gene activity, pathway activation, and molecular response to medications, lifestyle, and environment. | Tier | Price | Includes | |------|-------|----------| | RNA Profile | $499 USD | Complete transcriptome: 42,000 gene expressions | **How it works:** 1. Order online — kit ships within 2 business days 2. Collect a few blood drops at home (finger prick, dried blood spot card) 3. Ship back with pre-paid label 4. Receive results in 4 weeks **Clinical value:** - Dynamic health monitoring: RNA changes can precede visible symptoms - Personalized drug response: see if a therapy is achieving its intended molecular effect - Lifestyle feedback: exercise, diet, stress directly alter RNA signatures - Aging & longevity: certain RNA signatures track cellular aging - Repeatable over time for longitudinal tracking **Key evidence:** - RNA sequencing produced a diagnosis in nearly 1 in 4 patients where genome sequencing alone was indeterminate (ASHG research) - RNA reclassified 50% of ambiguous DNA variants from uncertain to actionable Product page: https://dantelabs.com/rna/ ### Oncology Genomic analysis for oncology care — specialized testing for cancer patients and their physicians. Product page: https://dantelabs.com/oncology/ --- ## Who We Help ### It Runs in My Family — Hereditary Risk For individuals with family history of cancer, cardiac conditions, neurological disease, or other inherited conditions. Whole genome sequencing identifies all inherited variants — not just the ones on a standard panel. A Mayo Clinic study published in JAMA Oncology (Samadder et al.) found that standard testing guidelines missed more than half of patients with inherited cancer mutations. Genome Test does not have a fixed list. URL: https://dantelabs.com/for/hereditary-risk/ ### I Can't Get a Diagnosis — Unexplained Symptoms For individuals who have undergone multiple tests without a clear answer. Standard diagnostic tests check for a pre-selected set of answers. Whole genome sequencing reads every region of DNA — including parts that no targeted test was designed to check. URL: https://dantelabs.com/for/undiagnosed/ ### My Treatment Isn't Working For individuals whose medications aren't producing expected results. Pharmacogenomics reveals how your DNA affects drug metabolism — explaining why certain treatments work for some patients but not others. Your physician can use this data to select more effective treatments. URL: https://dantelabs.com/for/treatment-not-working/ ### I Want to Know in Advance — Proactive Health For individuals who want the complete genetic picture before any symptoms appear. One test, taken once, providing a lifetime of insights that become more valuable as science advances. URL: https://dantelabs.com/for/proactive/ ### I've Already Tested Elsewhere — Upgrade For individuals who have previously taken consumer DNA tests, carrier panels, or other targeted genetic tests. These tests read less than 0.1% of the genome. Whole genome sequencing reads all of it. URL: https://dantelabs.com/upgrade/ --- ## Conditions Library Dante Labs maintains detailed clinical condition pages for 51 genetic conditions. Each page includes: clinical description from approved medical sources (Mayo Clinic, Cleveland Clinic, NCBI), an explanation of why whole genome sequencing is more comprehensive than targeted panel testing for that condition, and links to the relevant Genome Test. ### Hereditary Cancer - BRCA1 and BRCA2 — Hereditary Breast & Ovarian Cancer: https://dantelabs.com/conditions/brca-hereditary-breast-ovarian-cancer/ - Lynch Syndrome: https://dantelabs.com/conditions/lynch-syndrome/ - Li-Fraumeni Syndrome: https://dantelabs.com/conditions/li-fraumeni-syndrome/ - CHEK2 Hereditary Cancer Risk: https://dantelabs.com/conditions/chek2-hereditary-cancer-risk/ - Hereditary Prostate Cancer: https://dantelabs.com/conditions/hereditary-prostate-cancer/ - Hereditary Cancer Multi-Gene Panel: https://dantelabs.com/conditions/hereditary-cancer-multi-gene-panel/ - Multiple Endocrine Neoplasia: https://dantelabs.com/conditions/multiple-endocrine-neoplasia/ - RUNX1 Familial Platelet Disorder: https://dantelabs.com/conditions/runx1-familial-platelet-disorder/ ### Cardiovascular - Hypertrophic Cardiomyopathy: https://dantelabs.com/conditions/hypertrophic-cardiomyopathy/ - Dilated Cardiomyopathy: https://dantelabs.com/conditions/dilated-cardiomyopathy/ - Arrhythmogenic Cardiomyopathy (ARVC): https://dantelabs.com/conditions/arrhythmogenic-cardiomyopathy-arvc/ - Long QT Syndrome: https://dantelabs.com/conditions/long-qt-syndrome/ - Brugada Syndrome: https://dantelabs.com/conditions/brugada-syndrome/ - Aortic Aneurysm — Vascular Genetics: https://dantelabs.com/conditions/aortic-aneurysm-vascular-genetics/ - Familial Hypercholesterolemia: https://dantelabs.com/conditions/familial-hypercholesterolemia/ - Marfan Syndrome: https://dantelabs.com/conditions/marfan-syndrome/ ### Neurological - Alzheimer's and Dementia Risk: https://dantelabs.com/conditions/alzheimers-dementia-risk/ - Parkinson's Disease Risk: https://dantelabs.com/conditions/parkinsons-disease-risk/ - Huntington's Disease: https://dantelabs.com/conditions/huntingtons-disease/ - Autism Spectrum — Neurodevelopmental: https://dantelabs.com/conditions/autism-spectrum-neurodevelopmental/ - Charcot-Marie-Tooth Disease: https://dantelabs.com/conditions/charcot-marie-tooth-disease/ - Neurofibromatosis Type 1: https://dantelabs.com/conditions/neurofibromatosis-type-1/ - Noonan Syndrome: https://dantelabs.com/conditions/noonan-syndrome/ - Tuberous Sclerosis: https://dantelabs.com/conditions/tuberous-sclerosis/ ### Rare Diseases - Ehlers-Danlos Syndrome: https://dantelabs.com/conditions/ehlers-danlos-syndrome/ - Spinal Muscular Atrophy (SMA): https://dantelabs.com/conditions/spinal-muscular-atrophy-sma/ - Fragile X Syndrome: https://dantelabs.com/conditions/fragile-x-syndrome/ - Phenylketonuria (PKU): https://dantelabs.com/conditions/phenylketonuria-pku/ - Gaucher Disease: https://dantelabs.com/conditions/gaucher-disease/ - Wilson Disease: https://dantelabs.com/conditions/wilson-disease/ - Cerebral Cavernous Malformations: https://dantelabs.com/conditions/cerebral-cavernous-malformations/ - Von Hippel-Lindau Disease: https://dantelabs.com/conditions/von-hippel-lindau-disease/ - Hereditary Transthyretin Amyloidosis (ATTR): https://dantelabs.com/conditions/hereditary-transthyretin-amyloidosis-attr/ - Porphyria — Acute Intermittent: https://dantelabs.com/conditions/porphyria-acute-intermittent/ - Hemophilia A & B: https://dantelabs.com/conditions/hemophilia-a-b/ - Cystic Fibrosis Carrier Testing: https://dantelabs.com/conditions/cystic-fibrosis-carrier-testing/ ### Metabolic - MTHFR Gene Mutation: https://dantelabs.com/conditions/mthfr-gene-mutation/ - MTHFR: https://dantelabs.com/conditions/mthfr/ - Methylation & B12 Metabolism: https://dantelabs.com/conditions/methylation-b12-metabolism/ - Gilbert Syndrome: https://dantelabs.com/conditions/gilbert-syndrome/ - Hereditary Hemochromatosis: https://dantelabs.com/conditions/hereditary-hemochromatosis/ - COMT Warrior/Worrier Gene: https://dantelabs.com/conditions/comt-warrior-worrier-gene/ - Celiac Disease: https://dantelabs.com/conditions/celiac-disease/ ### Pharmacogenomics - Pharmacogenomics — Drug Response: https://dantelabs.com/conditions/pharmacogenomics-drug-response/ - Warfarin Sensitivity: https://dantelabs.com/conditions/warfarin-sensitivity/ - Statin Response (SLCO1B1): https://dantelabs.com/conditions/statin-response-slco1b1/ ### Autoimmune & Inflammatory - Rheumatoid Arthritis: https://dantelabs.com/conditions/rheumatoid-arthritis/ - Inflammatory Bowel Disease / Crohn's: https://dantelabs.com/conditions/inflammatory-bowel-disease-crohns/ - Familial Mediterranean Fever: https://dantelabs.com/conditions/familial-mediterranean-fever/ - Polycystic Ovary Syndrome (PCOS): https://dantelabs.com/conditions/polycystic-ovary-syndrome-pcos/ All conditions: https://dantelabs.com/conditions/ --- ## Frequently Asked Questions ### What is the difference between whole genome sequencing and a targeted genetic test? Targeted genetic tests — including standard hereditary cancer panels — read a pre-defined list of known variants in a specific set of genes. They are designed to find what they already know to look for. Whole genome sequencing reads your entire genome: all 6 billion base pairs, every gene, every region between genes. A Mayo Clinic study published in JAMA Oncology found that standard testing guidelines missed more than half of patients with inherited cancer mutations. ### What will I receive when my results are ready? Your Dante Genome delivers 200+ physician-ready reports organized by clinical category — hereditary cancer, cardiac conditions, rare diseases, pharmacogenomics, carrier status, and more. Reports are delivered to your secure Genome Manager and are formatted for direct clinical use. Your genome data is permanently retained and re-analyzed automatically as science advances. ### What happens if a clinically significant variant is found? If a pathogenic or likely-pathogenic variant is identified, it will be clearly flagged in your physician-ready report with clinical context, published evidence, and recommended next steps. We recommend sharing any clinically significant finding with your physician or a genetic counselor, who can guide decisions about surveillance, risk reduction, or cascade testing for family members. ### How is this different from consumer DNA tests? Consumer DNA tests use genotyping chips that read less than 0.1% of your genome — a tiny pre-selected set of common variants. They are optimized for ancestry and population-level traits, not clinical genetic findings. The Dante Genome Test sequences 100% of your genome at 30X coverage, the same standard used in clinical diagnostic settings. The two test types are not comparable in scope, methodology, or clinical utility. ### How long does it take to get results? Your collection kit ships within 48 hours of ordering. Once your sample arrives at the laboratory, sequencing and analysis takes 6 weeks for the Genome Test and 4 weeks for the RNA Profile. --- ## Outcomes & Evidence ### Patient Outcomes **40 years of uncertainty, one test:** A patient spent decades in the UK healthcare system without a diagnosis. Dante data, accepted by NHS clinical teams at Queen Elizabeth University Hospital Glasgow, identified Noonan Syndrome and a RUNX1 leukemia-associated variant. After 40 years, they finally had an answer. **A complete read delivers a complete picture:** A patient came to Dante to investigate periodic paralysis. Reading the complete genome identified a concurrent hereditary cardiac finding — Brugada Syndrome — that their doctor confirmed with an ECG. **Sequenced in 2019. The data worked in 2021:** Jennifer sequenced her genome two years before her breast cancer diagnosis. Dante's pharmacogenomics data showed her prescribed chemotherapy would cause serious adverse effects. Her doctor selected an alternative. Outcomes page: https://dantelabs.com/outcomes/ --- ## Laboratory Infrastructure - **Europe (including UK and Switzerland)**: Samples sequenced in Dante's Italian laboratory or clinical partner labs in Europe, all fully vetted. All labs hold European Union clinical accreditation through individual countries. - **US and Canada**: Samples sequenced in CLIA-accredited and CAP-certified laboratories in the US, using American sequencing platforms. - **Rest of World**: Samples sequenced in Europe, in Dante's clinical lab or vetted clinical partner labs. - All partner labs are vetted by Dante Labs, leveraging multi-year experience in genomics. - Reports are generated by Dante's validated interpretation software, following ACMG guidelines and other best practices adapted by country. --- ## Data Protection & Privacy - Data from EU samples is stored in Europe, in protected cloud environments and data centers. - If a non-EU sample is sequenced in Europe, that individual automatically receives GDPR protection because the sample was processed in Europe. - Full data ownership: unrestricted access to BAM, VCF, and FASTQ files. - Data is never shared with insurers, pharmaceutical companies, or research programs without explicit consent. - Biological sample is destroyed after results are ready. You can request data deletion at any time. --- ## Service & Delivery — 2026 Update In 2026, Dante Labs invested in additional sequencing capacity — both internally, with a new high-capacity instrument, and externally, through new clinical partnerships. A new customer support team has also been hired. Results for new orders are delivered within 6 weeks of sample arrival at the lab. Dante has delivered tens of thousands of genome results, impacting the lives of individuals worldwide. The company's science has been published in Nature Communications and Gene, and featured by the American Society of Human Genetics, European Society of Human Genetics, and several other established peer-reviewed journals and associations. --- ## Site Map ### Core Pages - Homepage: https://dantelabs.com/ - Whole Genome Sequencing: https://dantelabs.com/whole-genome-sequencing/ - Get Your Genome Test (Pricing): https://dantelabs.com/genome/ - RNA Profile: https://dantelabs.com/rna/ - Oncology: https://dantelabs.com/oncology/ - Our Science: https://dantelabs.com/our-science/ - Outcomes: https://dantelabs.com/outcomes/ - About: https://dantelabs.com/about/ - FAQ: https://dantelabs.com/faq/ - Contact: https://dantelabs.com/contact/ - Blog: https://dantelabs.com/blog/ - Affiliate Program: https://dantelabs.com/affiliates/ ### Persona Pages - Hereditary Risk: https://dantelabs.com/for/hereditary-risk/ - Undiagnosed: https://dantelabs.com/for/undiagnosed/ - Treatment Not Working: https://dantelabs.com/for/treatment-not-working/ - Proactive Health: https://dantelabs.com/for/proactive/ - Upgrade: https://dantelabs.com/upgrade/ ### Legal - Privacy Policy: https://dantelabs.com/privacy/ - Terms of Service: https://dantelabs.com/terms/ - Cookie Policy: https://dantelabs.com/cookie-policy/ - Data Protection: https://dantelabs.com/data-protection/ - GDPR: https://dantelabs.com/gdpr/