{
  "url": "https://dantelabs.com/traits/urolithiasis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "urolithiasis",
    "id": "HP:0034368",
    "name": "Urolithiasis",
    "definition": "Renal stones are formed within the kidneys, and this is called nephrolithiasis. Urolithiasis is a condition that occurs when these stones exit the renal pelvis and move into the remainder of the urinary collecting system, which includes the ureters, bladder, and urethra.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-ureter-morphology",
        "name": "Abnormal ureter morphology",
        "url": "https://dantelabs.com/traits/abnormal-ureter-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "aprt",
        "symbol": "APRT",
        "hgnc": "HGNC:626",
        "name": "adenine phosphoribosyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aprt"
      },
      {
        "slug": "prps1",
        "symbol": "PRPS1",
        "hgnc": "HGNC:9462",
        "name": "phosphoribosyl pyrophosphate synthetase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prps1"
      },
      {
        "slug": "slc22a12",
        "symbol": "SLC22A12",
        "hgnc": "HGNC:17989",
        "name": "solute carrier family 22 member 12",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc22a12"
      },
      {
        "slug": "gsn",
        "symbol": "GSN",
        "hgnc": "HGNC:4620",
        "name": "gelsolin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gsn"
      },
      {
        "slug": "ndc1",
        "symbol": "NDC1",
        "hgnc": "HGNC:25525",
        "name": "NDC1 transmembrane nucleoporin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndc1"
      }
    ]
  }
}