{
  "url": "https://dantelabs.com/traits/urinary-incontinence",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "urinary-incontinence",
    "id": "HP:0000020",
    "name": "Loss of bladder control",
    "label": "Urinary incontinence",
    "definition": "Loss of the ability to control the urinary bladder leading to involuntary urination.",
    "synonyms": [
      "Bladder incontinence"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      },
      {
        "slug": "constitutional-symptom",
        "name": "Constitutional symptom",
        "url": "https://dantelabs.com/traits/constitutional-symptom"
      }
    ],
    "broader": [
      {
        "slug": "functional-abnormality-of-the-bladder",
        "name": "Functional abnormality of the bladder",
        "url": "https://dantelabs.com/traits/functional-abnormality-of-the-bladder"
      },
      {
        "slug": "impaired-continence",
        "name": "Impaired continence",
        "url": "https://dantelabs.com/traits/impaired-continence"
      }
    ],
    "narrower": [
      {
        "slug": "stress-urinary-incontinence",
        "name": "Stress urinary incontinence",
        "genes": 1,
        "url": "https://dantelabs.com/traits/stress-urinary-incontinence"
      }
    ],
    "genes": [
      {
        "slug": "borcs8",
        "symbol": "BORCS8",
        "hgnc": "HGNC:37247",
        "name": "BLOC-1 related complex subunit 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/borcs8"
      },
      {
        "slug": "cst3",
        "symbol": "CST3",
        "hgnc": "HGNC:2475",
        "name": "cystatin C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cst3"
      },
      {
        "slug": "fryl",
        "symbol": "FRYL",
        "hgnc": "HGNC:29127",
        "name": "FRY like transcription coactivator",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fryl"
      },
      {
        "slug": "gaa",
        "symbol": "GAA",
        "hgnc": "HGNC:4065",
        "name": "alpha glucosidase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gaa"
      },
      {
        "slug": "gbe1",
        "symbol": "GBE1",
        "hgnc": "HGNC:4180",
        "name": "1,4-alpha-glucan branching enzyme 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gbe1"
      },
      {
        "slug": "ggt1",
        "symbol": "GGT1",
        "hgnc": "HGNC:4250",
        "name": "gamma-glutamyltransferase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ggt1"
      },
      {
        "slug": "hs6st2",
        "symbol": "HS6ST2",
        "hgnc": "HGNC:19133",
        "name": "heparan sulfate 6-O-sulfotransferase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hs6st2"
      },
      {
        "slug": "htra1",
        "symbol": "HTRA1",
        "hgnc": "HGNC:9476",
        "name": "HtrA serine peptidase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/htra1"
      },
      {
        "slug": "kmt2b",
        "symbol": "KMT2B",
        "hgnc": "HGNC:15840",
        "name": "lysine methyltransferase 2B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2b"
      },
      {
        "slug": "ky",
        "symbol": "KY",
        "hgnc": "HGNC:26576",
        "name": "kyphoscoliosis peptidase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ky"
      },
      {
        "slug": "nexmif",
        "symbol": "NEXMIF",
        "hgnc": "HGNC:29433",
        "name": "neurite extension and migration factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nexmif"
      },
      {
        "slug": "notch3",
        "symbol": "NOTCH3",
        "hgnc": "HGNC:7883",
        "name": "notch receptor 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/notch3"
      },
      {
        "slug": "pot1",
        "symbol": "POT1",
        "hgnc": "HGNC:17284",
        "name": "protection of telomeres 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pot1"
      },
      {
        "slug": "rsrc1",
        "symbol": "RSRC1",
        "hgnc": "HGNC:24152",
        "name": "arginine and serine rich coiled-coil 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsrc1"
      },
      {
        "slug": "slc44a1",
        "symbol": "SLC44A1",
        "hgnc": "HGNC:18798",
        "name": "solute carrier family 44 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc44a1"
      },
      {
        "slug": "top2b",
        "symbol": "TOP2B",
        "hgnc": "HGNC:11990",
        "name": "DNA topoisomerase II beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/top2b"
      },
      {
        "slug": "adnp",
        "symbol": "ADNP",
        "hgnc": "HGNC:15766",
        "name": "activity dependent neuroprotector homeobox",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adnp"
      },
      {
        "slug": "rtn2",
        "symbol": "RTN2",
        "hgnc": "HGNC:10468",
        "name": "reticulon 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rtn2"
      },
      {
        "slug": "acbd6",
        "symbol": "ACBD6",
        "hgnc": "HGNC:23339",
        "name": "acyl-CoA binding domain containing 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acbd6"
      },
      {
        "slug": "aldh18a1",
        "symbol": "ALDH18A1",
        "hgnc": "HGNC:9722",
        "name": "aldehyde dehydrogenase 18 family member A1",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/aldh18a1"
      },
      {
        "slug": "als2",
        "symbol": "ALS2",
        "hgnc": "HGNC:443",
        "name": "alsin Rho guanine nucleotide exchange factor ALS2",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/als2"
      },
      {
        "slug": "ap5z1",
        "symbol": "AP5Z1",
        "hgnc": "HGNC:22197",
        "name": "adaptor related protein complex 5 subunit zeta 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ap5z1"
      },
      {
        "slug": "arsa",
        "symbol": "ARSA",
        "hgnc": "HGNC:713",
        "name": "arylsulfatase A",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/arsa"
      },
      {
        "slug": "arx",
        "symbol": "ARX",
        "hgnc": "HGNC:18060",
        "name": "aristaless related homeobox",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arx"
      },
      {
        "slug": "atp13a2",
        "symbol": "ATP13A2",
        "hgnc": "HGNC:30213",
        "name": "ATPase cation transporting 13A2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp13a2"
      },
      {
        "slug": "atxn2",
        "symbol": "ATXN2",
        "hgnc": "HGNC:10555",
        "name": "ataxin 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn2"
      },
      {
        "slug": "copb1",
        "symbol": "COPB1",
        "hgnc": "HGNC:2231",
        "name": "coat protein complex I subunit beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/copb1"
      },
      {
        "slug": "cpt1c",
        "symbol": "CPT1C",
        "hgnc": "HGNC:18540",
        "name": "carnitine palmitoyltransferase 1C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cpt1c"
      },
      {
        "slug": "cyp7b1",
        "symbol": "CYP7B1",
        "hgnc": "HGNC:2652",
        "name": "cytochrome P450 family 7 subfamily B member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp7b1"
      },
      {
        "slug": "ddhd2",
        "symbol": "DDHD2",
        "hgnc": "HGNC:29106",
        "name": "DDHD domain containing 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddhd2"
      },
      {
        "slug": "dph5",
        "symbol": "DPH5",
        "hgnc": "HGNC:24270",
        "name": "diphthamide biosynthesis 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dph5"
      },
      {
        "slug": "gjc2",
        "symbol": "GJC2",
        "hgnc": "HGNC:17494",
        "name": "gap junction protein gamma 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjc2"
      },
      {
        "slug": "hpse2",
        "symbol": "HPSE2",
        "hgnc": "HGNC:18374",
        "name": "heparanase 2 (inactive)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hpse2"
      },
      {
        "slug": "hspd1",
        "symbol": "HSPD1",
        "hgnc": "HGNC:5261",
        "name": "heat shock protein family D (Hsp60) member 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hspd1"
      },
      {
        "slug": "kcnd3",
        "symbol": "KCND3",
        "hgnc": "HGNC:6239",
        "name": "potassium voltage-gated channel subfamily D member 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnd3"
      },
      {
        "slug": "lrig2",
        "symbol": "LRIG2",
        "hgnc": "HGNC:20889",
        "name": "leucine rich repeats and immunoglobulin like domains 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrig2"
      },
      {
        "slug": "myo1h",
        "symbol": "MYO1H",
        "hgnc": "HGNC:13879",
        "name": "myosin IH",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myo1h"
      },
      {
        "slug": "ngf",
        "symbol": "NGF",
        "hgnc": "HGNC:7808",
        "name": "nerve growth factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ngf"
      },
      {
        "slug": "notch2nlc",
        "symbol": "NOTCH2NLC",
        "hgnc": "HGNC:53924",
        "name": "notch 2 N-terminal like C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch2nlc"
      },
      {
        "slug": "ppfia3",
        "symbol": "PPFIA3",
        "hgnc": "HGNC:9247",
        "name": "PPFI scaffold protein A3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppfia3"
      },
      {
        "slug": "psap",
        "symbol": "PSAP",
        "hgnc": "HGNC:9498",
        "name": "prosaposin",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/psap"
      },
      {
        "slug": "sacs",
        "symbol": "SACS",
        "hgnc": "HGNC:10519",
        "name": "sacsin molecular chaperone",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sacs"
      },
      {
        "slug": "spg7",
        "symbol": "SPG7",
        "hgnc": "HGNC:11237",
        "name": "SPG7 matrix AAA peptidase subunit, paraplegin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spg7"
      },
      {
        "slug": "sqstm1",
        "symbol": "SQSTM1",
        "hgnc": "HGNC:11280",
        "name": "sequestosome 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sqstm1"
      },
      {
        "slug": "stub1",
        "symbol": "STUB1",
        "hgnc": "HGNC:11427",
        "name": "STIP1 homology and U-box containing protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stub1"
      },
      {
        "slug": "ubap1",
        "symbol": "UBAP1",
        "hgnc": "HGNC:12461",
        "name": "ubiquitin associated protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubap1"
      },
      {
        "slug": "vps13c",
        "symbol": "VPS13C",
        "hgnc": "HGNC:23594",
        "name": "vacuolar protein sorting 13 homolog C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps13c"
      },
      {
        "slug": "washc5",
        "symbol": "WASHC5",
        "hgnc": "HGNC:28984",
        "name": "WASH complex subunit 5",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/washc5"
      },
      {
        "slug": "zeb2",
        "symbol": "ZEB2",
        "hgnc": "HGNC:14881",
        "name": "zinc finger E-box binding homeobox 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/zeb2"
      },
      {
        "slug": "abcd1",
        "symbol": "ABCD1",
        "hgnc": "HGNC:61",
        "name": "ATP binding cassette subfamily D member 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/abcd1"
      },
      {
        "slug": "alms1",
        "symbol": "ALMS1",
        "hgnc": "HGNC:428",
        "name": "ALMS1 centrosome and basal body associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alms1"
      },
      {
        "slug": "atxn8",
        "symbol": "ATXN8",
        "hgnc": "HGNC:32925",
        "name": "ataxin 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn8"
      },
      {
        "slug": "atxn8os",
        "symbol": "ATXN8OS",
        "hgnc": "HGNC:10561",
        "name": "ATXN8 opposite strand lncRNA",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn8os"
      },
      {
        "slug": "bin1",
        "symbol": "BIN1",
        "hgnc": "HGNC:1052",
        "name": "bridging integrator 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bin1"
      },
      {
        "slug": "bnc2",
        "symbol": "BNC2",
        "hgnc": "HGNC:30988",
        "name": "basonuclin zinc finger protein 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/bnc2"
      },
      {
        "slug": "cabp4",
        "symbol": "CABP4",
        "hgnc": "HGNC:1386",
        "name": "calcium binding protein 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cabp4"
      },
      {
        "slug": "cacna1g",
        "symbol": "CACNA1G",
        "hgnc": "HGNC:1394",
        "name": "calcium voltage-gated channel subunit alpha1 G",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cacna1g"
      },
      {
        "slug": "capn1",
        "symbol": "CAPN1",
        "hgnc": "HGNC:1476",
        "name": "calpain 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/capn1"
      },
      {
        "slug": "chrna2",
        "symbol": "CHRNA2",
        "hgnc": "HGNC:1956",
        "name": "cholinergic receptor nicotinic alpha 2 subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrna2"
      },
      {
        "slug": "chrna4",
        "symbol": "CHRNA4",
        "hgnc": "HGNC:1958",
        "name": "cholinergic receptor nicotinic alpha 4 subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrna4"
      },
      {
        "slug": "chrnb2",
        "symbol": "CHRNB2",
        "hgnc": "HGNC:1962",
        "name": "cholinergic receptor nicotinic beta 2 subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrnb2"
      },
      {
        "slug": "cog5",
        "symbol": "COG5",
        "hgnc": "HGNC:14857",
        "name": "component of oligomeric golgi complex 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cog5"
      },
      {
        "slug": "crh",
        "symbol": "CRH",
        "hgnc": "HGNC:2355",
        "name": "corticotropin releasing hormone",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crh"
      },
      {
        "slug": "depdc5",
        "symbol": "DEPDC5",
        "hgnc": "HGNC:18423",
        "name": "DEP domain containing 5, GATOR1 subcomplex subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/depdc5"
      },
      {
        "slug": "dkk1",
        "symbol": "DKK1",
        "hgnc": "HGNC:2891",
        "name": "dickkopf Wnt signaling pathway inhibitor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dkk1"
      },
      {
        "slug": "dnm2",
        "symbol": "DNM2",
        "hgnc": "HGNC:2974",
        "name": "dynamin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnm2"
      },
      {
        "slug": "dnmt1",
        "symbol": "DNMT1",
        "hgnc": "HGNC:2976",
        "name": "DNA methyltransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnmt1"
      },
      {
        "slug": "eif2ak2",
        "symbol": "EIF2AK2",
        "hgnc": "HGNC:9437",
        "name": "eukaryotic translation initiation factor 2 alpha kinase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif2ak2"
      },
      {
        "slug": "erlin1",
        "symbol": "ERLIN1",
        "hgnc": "HGNC:16947",
        "name": "ER lipid raft associated 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erlin1"
      },
      {
        "slug": "fa2h",
        "symbol": "FA2H",
        "hgnc": "HGNC:21197",
        "name": "fatty acid 2-hydroxylase",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fa2h"
      },
      {
        "slug": "fars2",
        "symbol": "FARS2",
        "hgnc": "HGNC:21062",
        "name": "phenylalanyl-tRNA synthetase 2, mitochondrial",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fars2"
      },
      {
        "slug": "fgfr3",
        "symbol": "FGFR3",
        "hgnc": "HGNC:3690",
        "name": "fibroblast growth factor receptor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr3"
      },
      {
        "slug": "fitm2",
        "symbol": "FITM2",
        "hgnc": "HGNC:16135",
        "name": "fat storage inducing transmembrane protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fitm2"
      },
      {
        "slug": "frmd5",
        "symbol": "FRMD5",
        "hgnc": "HGNC:28214",
        "name": "FERM domain containing 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/frmd5"
      },
      {
        "slug": "fus",
        "symbol": "FUS",
        "hgnc": "HGNC:4010",
        "name": "FUS RNA binding protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fus"
      },
      {
        "slug": "gba2",
        "symbol": "GBA2",
        "hgnc": "HGNC:18986",
        "name": "glucosylceramidase beta 2",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gba2"
      },
      {
        "slug": "gne",
        "symbol": "GNE",
        "hgnc": "HGNC:23657",
        "name": "glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gne"
      },
      {
        "slug": "hace1",
        "symbol": "HACE1",
        "hgnc": "HGNC:21033",
        "name": "HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hace1"
      },
      {
        "slug": "hexb",
        "symbol": "HEXB",
        "hgnc": "HGNC:4879",
        "name": "hexosaminidase subunit beta",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hexb"
      },
      {
        "slug": "hps6",
        "symbol": "HPS6",
        "hgnc": "HGNC:18817",
        "name": "HPS6 biogenesis of lysosomal organelles complex 2 subunit 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hps6"
      },
      {
        "slug": "kcnc3",
        "symbol": "KCNC3",
        "hgnc": "HGNC:6235",
        "name": "potassium voltage-gated channel subfamily C member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnc3"
      },
      {
        "slug": "kcnt1",
        "symbol": "KCNT1",
        "hgnc": "HGNC:18865",
        "name": "potassium sodium-activated channel subfamily T member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnt1"
      },
      {
        "slug": "morc2",
        "symbol": "MORC2",
        "hgnc": "HGNC:23573",
        "name": "MORC family CW-type zinc finger 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/morc2"
      },
      {
        "slug": "mtmr14",
        "symbol": "MTMR14",
        "hgnc": "HGNC:26190",
        "name": "myotubularin related protein 14",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtmr14"
      },
      {
        "slug": "myf6",
        "symbol": "MYF6",
        "hgnc": "HGNC:7566",
        "name": "myogenic factor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myf6"
      },
      {
        "slug": "nefl",
        "symbol": "NEFL",
        "hgnc": "HGNC:7739",
        "name": "neurofilament light chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nefl"
      },
      {
        "slug": "nipa1",
        "symbol": "NIPA1",
        "hgnc": "HGNC:17043",
        "name": "NIPA magnesium transporter 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nipa1"
      },
      {
        "slug": "rnf170",
        "symbol": "RNF170",
        "hgnc": "HGNC:25358",
        "name": "ring finger protein 170",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf170"
      },
      {
        "slug": "ryr1",
        "symbol": "RYR1",
        "hgnc": "HGNC:10483",
        "name": "ryanodine receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ryr1"
      },
      {
        "slug": "sbf1",
        "symbol": "SBF1",
        "hgnc": "HGNC:10542",
        "name": "SET binding factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sbf1"
      },
      {
        "slug": "sigmar1",
        "symbol": "SIGMAR1",
        "hgnc": "HGNC:8157",
        "name": "sigma receptor chaperone 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sigmar1"
      },
      {
        "slug": "slc1a4",
        "symbol": "SLC1A4",
        "hgnc": "HGNC:10942",
        "name": "solute carrier family 1 member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc1a4"
      },
      {
        "slug": "sord",
        "symbol": "SORD",
        "hgnc": "HGNC:11184",
        "name": "sorbitol dehydrogenase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sord"
      },
      {
        "slug": "spg11",
        "symbol": "SPG11",
        "hgnc": "HGNC:11226",
        "name": "SPG11 vesicle trafficking associated, spatacsin",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/spg11"
      },
      {
        "slug": "sptlc1",
        "symbol": "SPTLC1",
        "hgnc": "HGNC:11277",
        "name": "serine palmitoyltransferase long chain base subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptlc1"
      },
      {
        "slug": "sptlc2",
        "symbol": "SPTLC2",
        "hgnc": "HGNC:11278",
        "name": "serine palmitoyltransferase long chain base subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptlc2"
      },
      {
        "slug": "syne1",
        "symbol": "SYNE1",
        "hgnc": "HGNC:17089",
        "name": "spectrin repeat containing nuclear envelope protein 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/syne1"
      },
      {
        "slug": "tardbp",
        "symbol": "TARDBP",
        "hgnc": "HGNC:11571",
        "name": "TAR DNA binding protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tardbp"
      },
      {
        "slug": "tbcd",
        "symbol": "TBCD",
        "hgnc": "HGNC:11581",
        "name": "tubulin folding cofactor D",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tbcd"
      },
      {
        "slug": "timm50",
        "symbol": "TIMM50",
        "hgnc": "HGNC:23656",
        "name": "translocase of inner mitochondrial membrane 50",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/timm50"
      },
      {
        "slug": "trio",
        "symbol": "TRIO",
        "hgnc": "HGNC:12303",
        "name": "trio Rho guanine nucleotide exchange factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trio"
      },
      {
        "slug": "trmt2b",
        "symbol": "TRMT2B",
        "hgnc": "HGNC:25748",
        "name": "tRNA methyltransferase 2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmt2b"
      },
      {
        "slug": "ubqln2",
        "symbol": "UBQLN2",
        "hgnc": "HGNC:12509",
        "name": "ubiquilin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubqln2"
      },
      {
        "slug": "vcp",
        "symbol": "VCP",
        "hgnc": "HGNC:12666",
        "name": "valosin containing protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vcp"
      },
      {
        "slug": "zmym2",
        "symbol": "ZMYM2",
        "hgnc": "HGNC:12989",
        "name": "zinc finger MYM-type containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmym2"
      },
      {
        "slug": "akt1",
        "symbol": "AKT1",
        "hgnc": "HGNC:391",
        "name": "AKT serine/threonine kinase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt1"
      },
      {
        "slug": "aldh3a2",
        "symbol": "ALDH3A2",
        "hgnc": "HGNC:403",
        "name": "aldehyde dehydrogenase 3 family member A2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh3a2"
      },
      {
        "slug": "bap1",
        "symbol": "BAP1",
        "hgnc": "HGNC:950",
        "name": "BRCA1 associated deubiquitinase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bap1"
      },
      {
        "slug": "cacna1h",
        "symbol": "CACNA1H",
        "hgnc": "HGNC:1395",
        "name": "calcium voltage-gated channel subunit alpha1 H",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1h"
      },
      {
        "slug": "clcnkb",
        "symbol": "CLCNKB",
        "hgnc": "HGNC:2027",
        "name": "chloride voltage-gated channel Kb",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcnkb"
      },
      {
        "slug": "gabra1",
        "symbol": "GABRA1",
        "hgnc": "HGNC:4075",
        "name": "gamma-aminobutyric acid type A receptor subunit alpha1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabra1"
      },
      {
        "slug": "gabrb3",
        "symbol": "GABRB3",
        "hgnc": "HGNC:4083",
        "name": "gamma-aminobutyric acid type A receptor subunit beta3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabrb3"
      },
      {
        "slug": "gabrg2",
        "symbol": "GABRG2",
        "hgnc": "HGNC:4087",
        "name": "gamma-aminobutyric acid type A receptor subunit gamma2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabrg2"
      },
      {
        "slug": "galc",
        "symbol": "GALC",
        "hgnc": "HGNC:4115",
        "name": "galactosylceramidase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galc"
      },
      {
        "slug": "hmbs",
        "symbol": "HMBS",
        "hgnc": "HGNC:4982",
        "name": "hydroxymethylbilane synthase",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hmbs"
      },
      {
        "slug": "jrk",
        "symbol": "JRK",
        "hgnc": "HGNC:6199",
        "name": "Jrk helix-turn-helix protein",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jrk"
      },
      {
        "slug": "nf2",
        "symbol": "NF2",
        "hgnc": "HGNC:7773",
        "name": "NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf2"
      },
      {
        "slug": "pdgfb",
        "symbol": "PDGFB",
        "hgnc": "HGNC:8800",
        "name": "platelet derived growth factor subunit B",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pdgfb"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "slc12a3",
        "symbol": "SLC12A3",
        "hgnc": "HGNC:10912",
        "name": "solute carrier family 12 member 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a3"
      },
      {
        "slug": "smarcb1",
        "symbol": "SMARCB1",
        "hgnc": "HGNC:11103",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit B1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcb1"
      },
      {
        "slug": "smarce1",
        "symbol": "SMARCE1",
        "hgnc": "HGNC:11109",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit E1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarce1"
      },
      {
        "slug": "smo",
        "symbol": "SMO",
        "hgnc": "HGNC:11119",
        "name": "smoothened, frizzled class receptor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smo"
      },
      {
        "slug": "sufu",
        "symbol": "SUFU",
        "hgnc": "HGNC:16466",
        "name": "SUFU negative regulator of hedgehog signaling",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sufu"
      },
      {
        "slug": "tert",
        "symbol": "TERT",
        "hgnc": "HGNC:11730",
        "name": "telomerase reverse transcriptase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tert"
      },
      {
        "slug": "traf7",
        "symbol": "TRAF7",
        "hgnc": "HGNC:20456",
        "name": "TNF receptor associated factor 7",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf7"
      },
      {
        "slug": "atl1",
        "symbol": "ATL1",
        "hgnc": "HGNC:11231",
        "name": "atlastin GTPase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atl1"
      },
      {
        "slug": "atxn10",
        "symbol": "ATXN10",
        "hgnc": "HGNC:10549",
        "name": "ataxin 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn10"
      },
      {
        "slug": "auh",
        "symbol": "AUH",
        "hgnc": "HGNC:890",
        "name": "AU RNA binding methylglutaconyl-CoA hydratase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/auh"
      },
      {
        "slug": "cfap43",
        "symbol": "CFAP43",
        "hgnc": "HGNC:26684",
        "name": "cilia and flagella associated protein 43",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap43"
      },
      {
        "slug": "chmp2b",
        "symbol": "CHMP2B",
        "hgnc": "HGNC:24537",
        "name": "charged multivesicular body protein 2B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chmp2b"
      },
      {
        "slug": "coq2",
        "symbol": "COQ2",
        "hgnc": "HGNC:25223",
        "name": "coenzyme Q2, polyprenyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq2"
      },
      {
        "slug": "flvcr1",
        "symbol": "FLVCR1",
        "hgnc": "HGNC:24682",
        "name": "FLVCR choline and heme transporter 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flvcr1"
      },
      {
        "slug": "fmr1",
        "symbol": "FMR1",
        "hgnc": "HGNC:3775",
        "name": "fragile X messenger ribonucleoprotein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fmr1"
      },
      {
        "slug": "fuz",
        "symbol": "FUZ",
        "hgnc": "HGNC:26219",
        "name": "fuzzy planar cell polarity protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fuz"
      },
      {
        "slug": "galnt2",
        "symbol": "GALNT2",
        "hgnc": "HGNC:4124",
        "name": "polypeptide N-acetylgalactosaminyltransferase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galnt2"
      },
      {
        "slug": "hla-dqb1",
        "symbol": "HLA-DQB1",
        "hgnc": "HGNC:4944",
        "name": "major histocompatibility complex, class II, DQ beta 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-dqb1"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "ift57",
        "symbol": "IFT57",
        "hgnc": "HGNC:17367",
        "name": "intraflagellar transport 57",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift57"
      },
      {
        "slug": "ighmbp2",
        "symbol": "IGHMBP2",
        "hgnc": "HGNC:5542",
        "name": "immunoglobulin mu DNA binding protein 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ighmbp2"
      },
      {
        "slug": "jam2",
        "symbol": "JAM2",
        "hgnc": "HGNC:14686",
        "name": "junctional adhesion molecule 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jam2"
      },
      {
        "slug": "kif5a",
        "symbol": "KIF5A",
        "hgnc": "HGNC:6323",
        "name": "kinesin family member 5A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif5a"
      },
      {
        "slug": "mnx1",
        "symbol": "MNX1",
        "hgnc": "HGNC:4979",
        "name": "motor neuron and pancreas homeobox 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mnx1"
      },
      {
        "slug": "myorg",
        "symbol": "MYORG",
        "hgnc": "HGNC:19918",
        "name": "myogenesis regulating glycosidase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myorg"
      },
      {
        "slug": "naa60",
        "symbol": "NAA60",
        "hgnc": "HGNC:25875",
        "name": "N-alpha-acetyltransferase 60, NatF catalytic subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naa60"
      },
      {
        "slug": "pank2",
        "symbol": "PANK2",
        "hgnc": "HGNC:15894",
        "name": "pantothenate kinase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pank2"
      },
      {
        "slug": "pdgfrb",
        "symbol": "PDGFRB",
        "hgnc": "HGNC:8804",
        "name": "platelet derived growth factor receptor beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdgfrb"
      },
      {
        "slug": "pex11b",
        "symbol": "PEX11B",
        "hgnc": "HGNC:8853",
        "name": "peroxisomal biogenesis factor 11 beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex11b"
      },
      {
        "slug": "prdm8",
        "symbol": "PRDM8",
        "hgnc": "HGNC:13993",
        "name": "PR/SET domain 8",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prdm8"
      },
      {
        "slug": "retreg1",
        "symbol": "RETREG1",
        "hgnc": "HGNC:25964",
        "name": "reticulophagy regulator 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/retreg1"
      },
      {
        "slug": "scn9a",
        "symbol": "SCN9A",
        "hgnc": "HGNC:10597",
        "name": "sodium voltage-gated channel alpha subunit 9",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn9a"
      },
      {
        "slug": "slc20a2",
        "symbol": "SLC20A2",
        "hgnc": "HGNC:10947",
        "name": "solute carrier family 20 member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc20a2"
      },
      {
        "slug": "slc9a6",
        "symbol": "SLC9A6",
        "hgnc": "HGNC:11079",
        "name": "solute carrier family 9 member A6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc9a6"
      },
      {
        "slug": "spast",
        "symbol": "SPAST",
        "hgnc": "HGNC:11233",
        "name": "spastin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spast"
      },
      {
        "slug": "tbp",
        "symbol": "TBP",
        "hgnc": "HGNC:11588",
        "name": "TATA-box binding protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbp"
      },
      {
        "slug": "tbxt",
        "symbol": "TBXT",
        "hgnc": "HGNC:11515",
        "name": "T-box transcription factor T",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbxt"
      },
      {
        "slug": "trem2",
        "symbol": "TREM2",
        "hgnc": "HGNC:17761",
        "name": "triggering receptor expressed on myeloid cells 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trem2"
      },
      {
        "slug": "trpv4",
        "symbol": "TRPV4",
        "hgnc": "HGNC:18083",
        "name": "transient receptor potential cation channel subfamily V member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpv4"
      },
      {
        "slug": "ttr",
        "symbol": "TTR",
        "hgnc": "HGNC:12405",
        "name": "transthyretin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttr"
      },
      {
        "slug": "tyrobp",
        "symbol": "TYROBP",
        "hgnc": "HGNC:12449",
        "name": "transmembrane immune signaling adaptor TYROBP",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tyrobp"
      },
      {
        "slug": "vangl1",
        "symbol": "VANGL1",
        "hgnc": "HGNC:15512",
        "name": "VANGL planar cell polarity protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vangl1"
      },
      {
        "slug": "vangl2",
        "symbol": "VANGL2",
        "hgnc": "HGNC:15511",
        "name": "VANGL planar cell polarity protein 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vangl2"
      },
      {
        "slug": "xpr1",
        "symbol": "XPR1",
        "hgnc": "HGNC:12827",
        "name": "xenotropic and polytropic retrovirus receptor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xpr1"
      },
      {
        "slug": "zc4h2",
        "symbol": "ZC4H2",
        "hgnc": "HGNC:24931",
        "name": "zinc finger C4H2-type containing",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zc4h2"
      },
      {
        "slug": "zfyve26",
        "symbol": "ZFYVE26",
        "hgnc": "HGNC:20761",
        "name": "zinc finger FYVE-type containing 26",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfyve26"
      }
    ]
  }
}