{
  "url": "https://dantelabs.com/traits/toe-syndactyly",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "toe-syndactyly",
    "id": "HP:0001770",
    "name": "Fused toes",
    "label": "Toe syndactyly",
    "definition": "Webbing or fusion of the toes, involving soft parts only or including bone structure. Bony fusions are referred to as \"bony\" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the toes in a proximo-distal axis are referred to as \"Symphalangism\".",
    "synonyms": [
      "Webbed toes",
      "Foot syndactyly",
      "Syndactyly of feet",
      "Syndactyly of toes"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-toe-morphology",
        "name": "Abnormalities of the toes",
        "url": "https://dantelabs.com/traits/abnormal-toe-morphology"
      },
      {
        "slug": "syndactyly",
        "name": "Webbed fingers or toes",
        "url": "https://dantelabs.com/traits/syndactyly"
      }
    ],
    "narrower": [
      {
        "slug": "2-3-toe-syndactyly",
        "name": "Webbed 2nd and 3rd toes",
        "genes": 97,
        "url": "https://dantelabs.com/traits/2-3-toe-syndactyly"
      },
      {
        "slug": "4-5-toe-syndactyly",
        "name": "Webbed 4th-5th toes",
        "genes": 14,
        "url": "https://dantelabs.com/traits/4-5-toe-syndactyly"
      },
      {
        "slug": "cutaneous-syndactyly-of-toes",
        "name": "Webbed skin of toes",
        "genes": 12,
        "url": "https://dantelabs.com/traits/cutaneous-syndactyly-of-toes"
      },
      {
        "slug": "3-4-toe-syndactyly",
        "name": "Webbed 3rd-4th toes",
        "genes": 7,
        "url": "https://dantelabs.com/traits/3-4-toe-syndactyly"
      },
      {
        "slug": "2-4-toe-syndactyly",
        "name": "Webbed 2nd-4th toes",
        "genes": 5,
        "url": "https://dantelabs.com/traits/2-4-toe-syndactyly"
      },
      {
        "slug": "2-5-toe-syndactyly",
        "name": "Webbed 2nd-5th toes",
        "genes": 4,
        "url": "https://dantelabs.com/traits/2-5-toe-syndactyly"
      },
      {
        "slug": "1-2-toe-syndactyly",
        "name": "Webbed first and second toes",
        "genes": 4,
        "url": "https://dantelabs.com/traits/1-2-toe-syndactyly"
      },
      {
        "slug": "1-3-toe-syndactyly",
        "name": "Webbed 1st-3rd toes",
        "genes": 1,
        "url": "https://dantelabs.com/traits/1-3-toe-syndactyly"
      },
      {
        "slug": "1-5-toe-syndactyly",
        "name": "Webbed 1st-5th toes",
        "genes": 1,
        "url": "https://dantelabs.com/traits/1-5-toe-syndactyly"
      },
      {
        "slug": "3-5-toe-syndactyly",
        "name": "Webbed 3rd-5th toes",
        "genes": 1,
        "url": "https://dantelabs.com/traits/3-5-toe-syndactyly"
      },
      {
        "slug": "1-4-toe-syndactyly",
        "name": "Webbed first through fourth toes",
        "genes": 1,
        "url": "https://dantelabs.com/traits/1-4-toe-syndactyly"
      }
    ],
    "genes": [
      {
        "slug": "ccnq",
        "symbol": "CCNQ",
        "hgnc": "HGNC:28434",
        "name": "cyclin Q",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ccnq"
      },
      {
        "slug": "donson",
        "symbol": "DONSON",
        "hgnc": "HGNC:2993",
        "name": "DNA replication fork stabilization factor DONSON",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/donson"
      },
      {
        "slug": "en1",
        "symbol": "EN1",
        "hgnc": "HGNC:3342",
        "name": "engrailed homeobox 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/en1"
      },
      {
        "slug": "megf8",
        "symbol": "MEGF8",
        "hgnc": "HGNC:3233",
        "name": "multiple EGF like domains 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/megf8"
      },
      {
        "slug": "mrps28",
        "symbol": "MRPS28",
        "hgnc": "HGNC:14513",
        "name": "mitochondrial ribosomal protein S28",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps28"
      },
      {
        "slug": "polr3gl",
        "symbol": "POLR3GL",
        "hgnc": "HGNC:28466",
        "name": "RNA polymerase III subunit GL",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr3gl"
      },
      {
        "slug": "pum1",
        "symbol": "PUM1",
        "hgnc": "HGNC:14957",
        "name": "pumilio RNA binding family member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pum1"
      },
      {
        "slug": "rab23",
        "symbol": "RAB23",
        "hgnc": "HGNC:14263",
        "name": "RAB23, member RAS oncogene family",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rab23"
      },
      {
        "slug": "scnm1",
        "symbol": "SCNM1",
        "hgnc": "HGNC:23136",
        "name": "sodium channel modifier 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnm1"
      },
      {
        "slug": "bhlha9",
        "symbol": "BHLHA9",
        "hgnc": "HGNC:35126",
        "name": "basic helix-loop-helix family member a9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bhlha9"
      },
      {
        "slug": "brd4",
        "symbol": "BRD4",
        "hgnc": "HGNC:13575",
        "name": "bromodomain containing 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brd4"
      },
      {
        "slug": "fgfr2",
        "symbol": "FGFR2",
        "hgnc": "HGNC:3689",
        "name": "fibroblast growth factor receptor 2",
        "frequency": "very-frequent",
        "diseases": 8,
        "url": "https://dantelabs.com/genes/fgfr2"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "hgnc": "HGNC:4274",
        "name": "gap junction protein alpha 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja1"
      },
      {
        "slug": "hdac8",
        "symbol": "HDAC8",
        "hgnc": "HGNC:13315",
        "name": "histone deacetylase 8",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hdac8"
      },
      {
        "slug": "hoxd13",
        "symbol": "HOXD13",
        "hgnc": "HGNC:5136",
        "name": "homeobox D13",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoxd13"
      },
      {
        "slug": "irf6",
        "symbol": "IRF6",
        "hgnc": "HGNC:6121",
        "name": "interferon regulatory factor 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf6"
      },
      {
        "slug": "lmbr1",
        "symbol": "LMBR1",
        "hgnc": "HGNC:13243",
        "name": "limb development membrane protein 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lmbr1"
      },
      {
        "slug": "mau2",
        "symbol": "MAU2",
        "hgnc": "HGNC:29140",
        "name": "MAU2 sister chromatid cohesion factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mau2"
      },
      {
        "slug": "mycn",
        "symbol": "MYCN",
        "hgnc": "HGNC:7559",
        "name": "MYCN proto-oncogene, bHLH transcription factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mycn"
      },
      {
        "slug": "nectin1",
        "symbol": "NECTIN1",
        "hgnc": "HGNC:9706",
        "name": "nectin cell adhesion molecule 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nectin1"
      },
      {
        "slug": "nipbl",
        "symbol": "NIPBL",
        "hgnc": "HGNC:28862",
        "name": "NIPBL cohesin loading factor",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nipbl"
      },
      {
        "slug": "nr4a2",
        "symbol": "NR4A2",
        "hgnc": "HGNC:7981",
        "name": "nuclear receptor subfamily 4 group A member 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr4a2"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "rad21",
        "symbol": "RAD21",
        "hgnc": "HGNC:9811",
        "name": "RAD21 cohesin complex component",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad21"
      },
      {
        "slug": "ripk4",
        "symbol": "RIPK4",
        "hgnc": "HGNC:496",
        "name": "receptor interacting serine/threonine kinase 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ripk4"
      },
      {
        "slug": "smc1a",
        "symbol": "SMC1A",
        "hgnc": "HGNC:11111",
        "name": "structural maintenance of chromosomes 1A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smc1a"
      },
      {
        "slug": "smc3",
        "symbol": "SMC3",
        "hgnc": "HGNC:2468",
        "name": "structural maintenance of chromosomes 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/smc3"
      },
      {
        "slug": "smoc1",
        "symbol": "SMOC1",
        "hgnc": "HGNC:20318",
        "name": "SPARC related modular calcium binding 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/smoc1"
      },
      {
        "slug": "tbr1",
        "symbol": "TBR1",
        "hgnc": "HGNC:11590",
        "name": "T-box brain transcription factor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbr1"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "frequency": "very-frequent",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/tp63"
      },
      {
        "slug": "apc",
        "symbol": "APC",
        "hgnc": "HGNC:583",
        "name": "APC regulator of Wnt signaling pathway",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apc"
      },
      {
        "slug": "b3glct",
        "symbol": "B3GLCT",
        "hgnc": "HGNC:20207",
        "name": "beta 3-glucosyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b3glct"
      },
      {
        "slug": "cplane1",
        "symbol": "CPLANE1",
        "hgnc": "HGNC:25801",
        "name": "ciliogenesis and planar polarity effector complex subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cplane1"
      },
      {
        "slug": "esco2",
        "symbol": "ESCO2",
        "hgnc": "HGNC:27230",
        "name": "establishment of sister chromatid cohesion N-acetyltransferase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/esco2"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "fli1",
        "symbol": "FLI1",
        "hgnc": "HGNC:3749",
        "name": "Fli-1 proto-oncogene, ETS transcription factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fli1"
      },
      {
        "slug": "fras1",
        "symbol": "FRAS1",
        "hgnc": "HGNC:19185",
        "name": "Fraser extracellular matrix complex subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fras1"
      },
      {
        "slug": "frem2",
        "symbol": "FREM2",
        "hgnc": "HGNC:25396",
        "name": "FRAS1 related extracellular matrix 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/frem2"
      },
      {
        "slug": "gli3",
        "symbol": "GLI3",
        "hgnc": "HGNC:4319",
        "name": "GLI family zinc finger 3",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gli3"
      },
      {
        "slug": "gpc3",
        "symbol": "GPC3",
        "hgnc": "HGNC:4451",
        "name": "glypican 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpc3"
      },
      {
        "slug": "gpc4",
        "symbol": "GPC4",
        "hgnc": "HGNC:4452",
        "name": "glypican 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpc4"
      },
      {
        "slug": "grip1",
        "symbol": "GRIP1",
        "hgnc": "HGNC:18708",
        "name": "glutamate receptor interacting protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grip1"
      },
      {
        "slug": "hdac4",
        "symbol": "HDAC4",
        "hgnc": "HGNC:14063",
        "name": "histone deacetylase 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hdac4"
      },
      {
        "slug": "iqsec2",
        "symbol": "IQSEC2",
        "hgnc": "HGNC:29059",
        "name": "IQ motif and Sec7 domain ArfGEF 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iqsec2"
      },
      {
        "slug": "kif7",
        "symbol": "KIF7",
        "hgnc": "HGNC:30497",
        "name": "kinesin family member 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif7"
      },
      {
        "slug": "lrp4",
        "symbol": "LRP4",
        "hgnc": "HGNC:6696",
        "name": "LDL receptor related protein 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp4"
      },
      {
        "slug": "mir17hg",
        "symbol": "MIR17HG",
        "hgnc": "HGNC:23564",
        "name": "miR-17-92a-1 cluster host gene",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mir17hg"
      },
      {
        "slug": "nog",
        "symbol": "NOG",
        "hgnc": "HGNC:7866",
        "name": "noggin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nog"
      },
      {
        "slug": "pigy",
        "symbol": "PIGY",
        "hgnc": "HGNC:28213",
        "name": "phosphatidylinositol glycan anchor biosynthesis class Y",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigy"
      },
      {
        "slug": "psat1",
        "symbol": "PSAT1",
        "hgnc": "HGNC:19129",
        "name": "phosphoserine aminotransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psat1"
      },
      {
        "slug": "rai1",
        "symbol": "RAI1",
        "hgnc": "HGNC:9834",
        "name": "retinoic acid induced 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rai1"
      },
      {
        "slug": "sc5d",
        "symbol": "SC5D",
        "hgnc": "HGNC:10547",
        "name": "sterol-C5-desaturase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sc5d"
      },
      {
        "slug": "shh",
        "symbol": "SHH",
        "hgnc": "HGNC:10848",
        "name": "sonic hedgehog signaling molecule",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/shh"
      },
      {
        "slug": "smad2",
        "symbol": "SMAD2",
        "hgnc": "HGNC:6768",
        "name": "SMAD family member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smad2"
      },
      {
        "slug": "smo",
        "symbol": "SMO",
        "hgnc": "HGNC:11119",
        "name": "smoothened, frizzled class receptor",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/smo"
      },
      {
        "slug": "tshz3",
        "symbol": "TSHZ3",
        "hgnc": "HGNC:30700",
        "name": "teashirt zinc finger homeobox 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tshz3"
      },
      {
        "slug": "wls",
        "symbol": "WLS",
        "hgnc": "HGNC:30238",
        "name": "Wnt ligand secretion mediator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wls"
      },
      {
        "slug": "wnt7a",
        "symbol": "WNT7A",
        "hgnc": "HGNC:12786",
        "name": "Wnt family member 7A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt7a"
      },
      {
        "slug": "arl6ip6",
        "symbol": "ARL6IP6",
        "hgnc": "HGNC:24048",
        "name": "ARF like GTPase 6 interacting protein 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arl6ip6"
      },
      {
        "slug": "bcr",
        "symbol": "BCR",
        "hgnc": "HGNC:1014",
        "name": "BCR activator of RhoGEF and GTPase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcr"
      },
      {
        "slug": "bms1",
        "symbol": "BMS1",
        "hgnc": "HGNC:23505",
        "name": "BMS1 ribosome biogenesis factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bms1"
      },
      {
        "slug": "brca1",
        "symbol": "BRCA1",
        "hgnc": "HGNC:1100",
        "name": "BRCA1 DNA repair associated",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brca1"
      },
      {
        "slug": "brca2",
        "symbol": "BRCA2",
        "hgnc": "HGNC:1101",
        "name": "BRCA2 DNA repair associated",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brca2"
      },
      {
        "slug": "brip1",
        "symbol": "BRIP1",
        "hgnc": "HGNC:20473",
        "name": "BRCA1 interacting DNA helicase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brip1"
      },
      {
        "slug": "cd96",
        "symbol": "CD96",
        "hgnc": "HGNC:16892",
        "name": "CD96 molecule",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cd96"
      },
      {
        "slug": "cep120",
        "symbol": "CEP120",
        "hgnc": "HGNC:26690",
        "name": "centrosomal protein 120",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep120"
      },
      {
        "slug": "crkl",
        "symbol": "CRKL",
        "hgnc": "HGNC:2363",
        "name": "CRK like proto-oncogene, adaptor protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crkl"
      },
      {
        "slug": "cul4b",
        "symbol": "CUL4B",
        "hgnc": "HGNC:2555",
        "name": "cullin 4B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cul4b"
      },
      {
        "slug": "dact1",
        "symbol": "DACT1",
        "hgnc": "HGNC:17748",
        "name": "dishevelled binding antagonist of beta catenin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dact1"
      },
      {
        "slug": "dll4",
        "symbol": "DLL4",
        "hgnc": "HGNC:2910",
        "name": "delta like canonical Notch ligand 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dll4"
      },
      {
        "slug": "dync2h1",
        "symbol": "DYNC2H1",
        "hgnc": "HGNC:2962",
        "name": "dynein cytoplasmic 2 heavy chain 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync2h1"
      },
      {
        "slug": "dync2i1",
        "symbol": "DYNC2I1",
        "hgnc": "HGNC:21862",
        "name": "dynein 2 intermediate chain 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync2i1"
      },
      {
        "slug": "dync2i2",
        "symbol": "DYNC2I2",
        "hgnc": "HGNC:28296",
        "name": "dynein 2 intermediate chain 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync2i2"
      },
      {
        "slug": "dync2li1",
        "symbol": "DYNC2LI1",
        "hgnc": "HGNC:24595",
        "name": "dynein cytoplasmic 2 light intermediate chain 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync2li1"
      },
      {
        "slug": "ercc4",
        "symbol": "ERCC4",
        "hgnc": "HGNC:3436",
        "name": "ERCC excision repair 4, endonuclease catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc4"
      },
      {
        "slug": "faap100",
        "symbol": "FAAP100",
        "hgnc": "HGNC:26171",
        "name": "FA core complex associated protein 100",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faap100"
      },
      {
        "slug": "fanca",
        "symbol": "FANCA",
        "hgnc": "HGNC:3582",
        "name": "FA complementation group A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fanca"
      },
      {
        "slug": "fancb",
        "symbol": "FANCB",
        "hgnc": "HGNC:3583",
        "name": "FA complementation group B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancb"
      },
      {
        "slug": "fancc",
        "symbol": "FANCC",
        "hgnc": "HGNC:3584",
        "name": "FA complementation group C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancc"
      },
      {
        "slug": "fancd2",
        "symbol": "FANCD2",
        "hgnc": "HGNC:3585",
        "name": "FA complementation group D2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancd2"
      },
      {
        "slug": "fance",
        "symbol": "FANCE",
        "hgnc": "HGNC:3586",
        "name": "FA complementation group E",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fance"
      },
      {
        "slug": "fancf",
        "symbol": "FANCF",
        "hgnc": "HGNC:3587",
        "name": "FA complementation group F",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancf"
      },
      {
        "slug": "fancg",
        "symbol": "FANCG",
        "hgnc": "HGNC:3588",
        "name": "FA complementation group G",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancg"
      },
      {
        "slug": "fanci",
        "symbol": "FANCI",
        "hgnc": "HGNC:25568",
        "name": "FA complementation group I",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fanci"
      },
      {
        "slug": "fancl",
        "symbol": "FANCL",
        "hgnc": "HGNC:20748",
        "name": "FA complementation group L",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancl"
      },
      {
        "slug": "fancm",
        "symbol": "FANCM",
        "hgnc": "HGNC:23168",
        "name": "FA complementation group M",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancm"
      },
      {
        "slug": "fbxo11",
        "symbol": "FBXO11",
        "hgnc": "HGNC:13590",
        "name": "F-box protein 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo11"
      },
      {
        "slug": "fgf10",
        "symbol": "FGF10",
        "hgnc": "HGNC:3666",
        "name": "fibroblast growth factor 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf10"
      },
      {
        "slug": "fgfr3",
        "symbol": "FGFR3",
        "hgnc": "HGNC:3690",
        "name": "fibroblast growth factor receptor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr3"
      },
      {
        "slug": "gna11",
        "symbol": "GNA11",
        "hgnc": "HGNC:4379",
        "name": "G protein subunit alpha 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gna11"
      },
      {
        "slug": "h3-3a",
        "symbol": "H3-3A",
        "hgnc": "HGNC:4764",
        "name": "H3.3 histone A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h3-3a"
      },
      {
        "slug": "ift140",
        "symbol": "IFT140",
        "hgnc": "HGNC:29077",
        "name": "intraflagellar transport 140",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift140"
      },
      {
        "slug": "ift172",
        "symbol": "IFT172",
        "hgnc": "HGNC:30391",
        "name": "intraflagellar transport 172",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift172"
      },
      {
        "slug": "ift80",
        "symbol": "IFT80",
        "hgnc": "HGNC:29262",
        "name": "intraflagellar transport 80",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift80"
      },
      {
        "slug": "itgb4",
        "symbol": "ITGB4",
        "hgnc": "HGNC:6158",
        "name": "integrin subunit beta 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgb4"
      },
      {
        "slug": "kiaa0753",
        "symbol": "KIAA0753",
        "hgnc": "HGNC:29110",
        "name": "KIAA0753",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kiaa0753"
      },
      {
        "slug": "mad2l2",
        "symbol": "MAD2L2",
        "hgnc": "HGNC:6764",
        "name": "mitotic arrest deficient 2 like 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mad2l2"
      },
      {
        "slug": "mapk1",
        "symbol": "MAPK1",
        "hgnc": "HGNC:6871",
        "name": "mitogen-activated protein kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mapk1"
      },
      {
        "slug": "mef2c",
        "symbol": "MEF2C",
        "hgnc": "HGNC:6996",
        "name": "myocyte enhancer factor 2C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mef2c"
      },
      {
        "slug": "nek9",
        "symbol": "NEK9",
        "hgnc": "HGNC:18591",
        "name": "NIMA related kinase 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek9"
      },
      {
        "slug": "nxn",
        "symbol": "NXN",
        "hgnc": "HGNC:18008",
        "name": "nucleoredoxin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nxn"
      },
      {
        "slug": "otud6b",
        "symbol": "OTUD6B",
        "hgnc": "HGNC:24281",
        "name": "OTU deubiquitinase 6B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otud6b"
      },
      {
        "slug": "palb2",
        "symbol": "PALB2",
        "hgnc": "HGNC:26144",
        "name": "partner and localizer of BRCA2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/palb2"
      },
      {
        "slug": "plec",
        "symbol": "PLEC",
        "hgnc": "HGNC:9069",
        "name": "plectin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plec"
      },
      {
        "slug": "rad51",
        "symbol": "RAD51",
        "hgnc": "HGNC:9817",
        "name": "RAD51 recombinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad51"
      },
      {
        "slug": "rad51c",
        "symbol": "RAD51C",
        "hgnc": "HGNC:9820",
        "name": "RAD51 paralog C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad51c"
      },
      {
        "slug": "rfwd3",
        "symbol": "RFWD3",
        "hgnc": "HGNC:25539",
        "name": "ring finger and WD repeat domain 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfwd3"
      },
      {
        "slug": "ror2",
        "symbol": "ROR2",
        "hgnc": "HGNC:10257",
        "name": "ROR family WNT receptor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ror2"
      },
      {
        "slug": "rpl10",
        "symbol": "RPL10",
        "hgnc": "HGNC:10298",
        "name": "ribosomal protein L10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl10"
      },
      {
        "slug": "sall1",
        "symbol": "SALL1",
        "hgnc": "HGNC:10524",
        "name": "spalt like transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sall1"
      },
      {
        "slug": "sall4",
        "symbol": "SALL4",
        "hgnc": "HGNC:15924",
        "name": "spalt like transcription factor 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sall4"
      },
      {
        "slug": "sin3a",
        "symbol": "SIN3A",
        "hgnc": "HGNC:19353",
        "name": "SIN3 transcription regulator family member A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sin3a"
      },
      {
        "slug": "slx4",
        "symbol": "SLX4",
        "hgnc": "HGNC:23845",
        "name": "SLX4 structure-specific endonuclease subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slx4"
      },
      {
        "slug": "tbx22",
        "symbol": "TBX22",
        "hgnc": "HGNC:11600",
        "name": "T-box transcription factor 22",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx22"
      },
      {
        "slug": "tfap2b",
        "symbol": "TFAP2B",
        "hgnc": "HGNC:11743",
        "name": "transcription factor AP-2 beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tfap2b"
      },
      {
        "slug": "ttc21b",
        "symbol": "TTC21B",
        "hgnc": "HGNC:25660",
        "name": "tetratricopeptide repeat domain 21B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttc21b"
      },
      {
        "slug": "twist2",
        "symbol": "TWIST2",
        "hgnc": "HGNC:20670",
        "name": "twist family bHLH transcription factor 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/twist2"
      },
      {
        "slug": "uba2",
        "symbol": "UBA2",
        "hgnc": "HGNC:30661",
        "name": "ubiquitin like modifier activating enzyme 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uba2"
      },
      {
        "slug": "ube2t",
        "symbol": "UBE2T",
        "hgnc": "HGNC:25009",
        "name": "ubiquitin conjugating enzyme E2 T",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube2t"
      },
      {
        "slug": "wdr19",
        "symbol": "WDR19",
        "hgnc": "HGNC:18340",
        "name": "WD repeat domain 19",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr19"
      },
      {
        "slug": "xrcc2",
        "symbol": "XRCC2",
        "hgnc": "HGNC:12829",
        "name": "X-ray repair cross complementing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xrcc2"
      },
      {
        "slug": "znf699",
        "symbol": "ZNF699",
        "hgnc": "HGNC:24750",
        "name": "zinc finger protein 699",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf699"
      },
      {
        "slug": "ctcf",
        "symbol": "CTCF",
        "hgnc": "HGNC:13723",
        "name": "CCCTC-binding factor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctcf"
      },
      {
        "slug": "arhgap31",
        "symbol": "ARHGAP31",
        "hgnc": "HGNC:29216",
        "name": "Rho GTPase activating protein 31",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgap31"
      },
      {
        "slug": "atp6v1b2",
        "symbol": "ATP6V1B2",
        "hgnc": "HGNC:854",
        "name": "ATPase H+ transporting V1 subunit B2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v1b2"
      },
      {
        "slug": "bmp4",
        "symbol": "BMP4",
        "hgnc": "HGNC:1071",
        "name": "bone morphogenetic protein 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmp4"
      },
      {
        "slug": "efnb1",
        "symbol": "EFNB1",
        "hgnc": "HGNC:3226",
        "name": "ephrin B1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efnb1"
      },
      {
        "slug": "fig4",
        "symbol": "FIG4",
        "hgnc": "HGNC:16873",
        "name": "FIG4 phosphoinositide 5-phosphatase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fig4"
      },
      {
        "slug": "flna",
        "symbol": "FLNA",
        "hgnc": "HGNC:3754",
        "name": "filamin A",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/flna"
      },
      {
        "slug": "kcnj2",
        "symbol": "KCNJ2",
        "hgnc": "HGNC:6263",
        "name": "potassium inwardly rectifying channel subfamily J member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj2"
      },
      {
        "slug": "phgdh",
        "symbol": "PHGDH",
        "hgnc": "HGNC:8923",
        "name": "phosphoglycerate dehydrogenase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phgdh"
      },
      {
        "slug": "porcn",
        "symbol": "PORCN",
        "hgnc": "HGNC:17652",
        "name": "porcupine O-acyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/porcn"
      },
      {
        "slug": "sf3b4",
        "symbol": "SF3B4",
        "hgnc": "HGNC:10771",
        "name": "splicing factor 3b subunit 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sf3b4"
      },
      {
        "slug": "tbc1d32",
        "symbol": "TBC1D32",
        "hgnc": "HGNC:21485",
        "name": "TBC1 domain family member 32",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d32"
      },
      {
        "slug": "tctn3",
        "symbol": "TCTN3",
        "hgnc": "HGNC:24519",
        "name": "tectonic family member 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tctn3"
      },
      {
        "slug": "twist1",
        "symbol": "TWIST1",
        "hgnc": "HGNC:12428",
        "name": "twist family bHLH transcription factor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twist1"
      },
      {
        "slug": "wnt10b",
        "symbol": "WNT10B",
        "hgnc": "HGNC:12775",
        "name": "Wnt family member 10B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt10b"
      }
    ]
  }
}