{
  "url": "https://dantelabs.com/traits/thin-glomerular-basement-membrane",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "thin-glomerular-basement-membrane",
    "id": "HP:0012577",
    "name": "Thin glomerular basement membrane",
    "definition": "Decreased thickness of the glomerular basement membrane (GBM), measured from endothelial to visceral epithelial plasma membrane and mainly attributable to a decrease in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations less than that of the normal mean GBM thickness for health age- and sex matched individuals. May be focal or diffuse, although the term thin GBMs generally implies thinning of over 50% of GBMs.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-glomerular-basement-membrane-morphology",
        "name": "Abnormal glomerular basement membrane morphology",
        "url": "https://dantelabs.com/traits/abnormal-glomerular-basement-membrane-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "col4a3",
        "symbol": "COL4A3",
        "hgnc": "HGNC:2204",
        "name": "collagen type IV alpha 3 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a3"
      },
      {
        "slug": "arhgdia",
        "symbol": "ARHGDIA",
        "hgnc": "HGNC:678",
        "name": "Rho GDP dissociation inhibitor alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgdia"
      },
      {
        "slug": "col4a4",
        "symbol": "COL4A4",
        "hgnc": "HGNC:2206",
        "name": "collagen type IV alpha 4 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a4"
      }
    ]
  }
}