{
  "url": "https://dantelabs.com/traits/tessier-cleft",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "tessier-cleft",
    "id": "HP:0002006",
    "name": "Cleft of the face",
    "label": "Tessier cleft",
    "definition": "A congenital malformation with a cleft (gap or opening) in the face.",
    "synonyms": [
      "Facial cleft",
      "Facial clefts",
      "Tessier facial cleft"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-face",
        "name": "Abnormality of the face",
        "url": "https://dantelabs.com/traits/abnormality-of-the-face"
      },
      {
        "slug": "craniofacial-cleft",
        "name": "Craniofacial cleft",
        "url": "https://dantelabs.com/traits/craniofacial-cleft"
      }
    ],
    "narrower": [
      {
        "slug": "midline-facial-cleft",
        "name": "Midline facial cleft",
        "genes": 2,
        "url": "https://dantelabs.com/traits/midline-facial-cleft"
      },
      {
        "slug": "transverse-facial-cleft",
        "name": "Transverse facial cleft",
        "genes": 1,
        "url": "https://dantelabs.com/traits/transverse-facial-cleft"
      },
      {
        "slug": "orbital-cleft",
        "name": "Orbital cleft",
        "genes": 0,
        "url": "https://dantelabs.com/traits/orbital-cleft"
      },
      {
        "slug": "paramedian-facial-cleft",
        "name": "Paramedian facial cleft",
        "genes": 0,
        "url": "https://dantelabs.com/traits/paramedian-facial-cleft"
      }
    ],
    "genes": [
      {
        "slug": "ripk4",
        "symbol": "RIPK4",
        "hgnc": "HGNC:496",
        "name": "receptor interacting serine/threonine kinase 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ripk4"
      },
      {
        "slug": "alx1",
        "symbol": "ALX1",
        "hgnc": "HGNC:1494",
        "name": "ALX homeobox 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/alx1"
      },
      {
        "slug": "ctnnb1",
        "symbol": "CTNNB1",
        "hgnc": "HGNC:2514",
        "name": "catenin beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctnnb1"
      },
      {
        "slug": "evc",
        "symbol": "EVC",
        "hgnc": "HGNC:3497",
        "name": "EvC ciliary complex subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/evc"
      },
      {
        "slug": "evc2",
        "symbol": "EVC2",
        "hgnc": "HGNC:19747",
        "name": "EvC ciliary complex subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/evc2"
      },
      {
        "slug": "dync2h1",
        "symbol": "DYNC2H1",
        "hgnc": "HGNC:2962",
        "name": "dynein cytoplasmic 2 heavy chain 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync2h1"
      },
      {
        "slug": "dync2i1",
        "symbol": "DYNC2I1",
        "hgnc": "HGNC:21862",
        "name": "dynein 2 intermediate chain 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync2i1"
      },
      {
        "slug": "dync2i2",
        "symbol": "DYNC2I2",
        "hgnc": "HGNC:28296",
        "name": "dynein 2 intermediate chain 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync2i2"
      },
      {
        "slug": "ift80",
        "symbol": "IFT80",
        "hgnc": "HGNC:29262",
        "name": "intraflagellar transport 80",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift80"
      },
      {
        "slug": "polr1b",
        "symbol": "POLR1B",
        "hgnc": "HGNC:20454",
        "name": "RNA polymerase I subunit B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1b"
      },
      {
        "slug": "polr1c",
        "symbol": "POLR1C",
        "hgnc": "HGNC:20194",
        "name": "RNA polymerase I and III subunit C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1c"
      },
      {
        "slug": "polr1d",
        "symbol": "POLR1D",
        "hgnc": "HGNC:20422",
        "name": "RNA polymerase I and III subunit D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1d"
      },
      {
        "slug": "tcof1",
        "symbol": "TCOF1",
        "hgnc": "HGNC:11654",
        "name": "treacle ribosome biogenesis factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcof1"
      },
      {
        "slug": "wdr35",
        "symbol": "WDR35",
        "hgnc": "HGNC:29250",
        "name": "WD repeat domain 35",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr35"
      },
      {
        "slug": "colec10",
        "symbol": "COLEC10",
        "hgnc": "HGNC:2220",
        "name": "collectin subfamily member 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/colec10"
      },
      {
        "slug": "fras1",
        "symbol": "FRAS1",
        "hgnc": "HGNC:19185",
        "name": "Fraser extracellular matrix complex subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fras1"
      }
    ]
  }
}