{
  "url": "https://dantelabs.com/traits/severe-periodontitis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "severe-periodontitis",
    "id": "HP:0000166",
    "name": "Severe gum disease",
    "label": "Severe periodontitis",
    "definition": "Increased susceptibility to periodontitis, as manifested by severe periodontal infection with rapid alveolar bone loss, tooth mobility, and premature tooth exfoliation.",
    "synonyms": [
      "Early-onset aggressive periodontitis",
      "Prepubertal periodontitis",
      "Severe aggressive periodontitis",
      "Severe periodontal disease",
      "Severe pyorrhea"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "unusual-periodontitis",
        "name": "Unusual periodontitis",
        "url": "https://dantelabs.com/traits/unusual-periodontitis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ctsc",
        "symbol": "CTSC",
        "hgnc": "HGNC:2528",
        "name": "cathepsin C",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/ctsc"
      },
      {
        "slug": "skor2",
        "symbol": "SKOR2",
        "hgnc": "HGNC:32695",
        "name": "SKI family transcriptional corepressor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/skor2"
      },
      {
        "slug": "c1r",
        "symbol": "C1R",
        "hgnc": "HGNC:1246",
        "name": "complement C1r",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1r"
      },
      {
        "slug": "c1s",
        "symbol": "C1S",
        "hgnc": "HGNC:1247",
        "name": "complement C1s",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1s"
      },
      {
        "slug": "cat",
        "symbol": "CAT",
        "hgnc": "HGNC:1516",
        "name": "catalase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cat"
      },
      {
        "slug": "slc35c1",
        "symbol": "SLC35C1",
        "hgnc": "HGNC:20197",
        "name": "solute carrier family 35 member C1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc35c1"
      },
      {
        "slug": "cxcr4",
        "symbol": "CXCR4",
        "hgnc": "HGNC:2561",
        "name": "C-X-C motif chemokine receptor 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cxcr4"
      }
    ]
  }
}