{
  "url": "https://dantelabs.com/traits/prolonged-qtc-interval",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "prolonged-qtc-interval",
    "id": "HP:0005184",
    "name": "Prolonged QTc interval",
    "definition": "A longer than normal interval (corrected for heart rate) between the Q and T waves in the heart's cycle. Prolonged QTc can cause premature action potentials during late phase depolarizations thereby leading to ventricular arrhythmias and ventricular fibrillations.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "prolonged-qt-interval",
        "name": "Prolonged QT interval",
        "url": "https://dantelabs.com/traits/prolonged-qt-interval"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "akap9",
        "symbol": "AKAP9",
        "hgnc": "HGNC:379",
        "name": "A-kinase anchoring protein 9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akap9"
      },
      {
        "slug": "alg10b",
        "symbol": "ALG10B",
        "hgnc": "HGNC:31088",
        "name": "ALG10 alpha-1,2-glucosyltransferase B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg10b"
      },
      {
        "slug": "cacna1c",
        "symbol": "CACNA1C",
        "hgnc": "HGNC:1390",
        "name": "calcium voltage-gated channel subunit alpha1 C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1c"
      },
      {
        "slug": "calm1",
        "symbol": "CALM1",
        "hgnc": "HGNC:1442",
        "name": "calmodulin 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calm1"
      },
      {
        "slug": "calm2",
        "symbol": "CALM2",
        "hgnc": "HGNC:1445",
        "name": "calmodulin 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calm2"
      },
      {
        "slug": "calm3",
        "symbol": "CALM3",
        "hgnc": "HGNC:1449",
        "name": "calmodulin 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calm3"
      },
      {
        "slug": "gys1",
        "symbol": "GYS1",
        "hgnc": "HGNC:4706",
        "name": "glycogen synthase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gys1"
      },
      {
        "slug": "kcne2",
        "symbol": "KCNE2",
        "hgnc": "HGNC:6242",
        "name": "potassium voltage-gated channel subfamily E regulatory subunit 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcne2"
      },
      {
        "slug": "kcnh2",
        "symbol": "KCNH2",
        "hgnc": "HGNC:6251",
        "name": "potassium voltage-gated channel subfamily H member 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnh2"
      },
      {
        "slug": "kcnq1",
        "symbol": "KCNQ1",
        "hgnc": "HGNC:6294",
        "name": "potassium voltage-gated channel subfamily Q member 1",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/kcnq1"
      },
      {
        "slug": "nrap",
        "symbol": "NRAP",
        "hgnc": "HGNC:7988",
        "name": "nebulin related anchoring protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nrap"
      },
      {
        "slug": "scn5a",
        "symbol": "SCN5A",
        "hgnc": "HGNC:10593",
        "name": "sodium voltage-gated channel alpha subunit 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn5a"
      },
      {
        "slug": "snta1",
        "symbol": "SNTA1",
        "hgnc": "HGNC:11167",
        "name": "syntrophin alpha 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snta1"
      },
      {
        "slug": "kcne1",
        "symbol": "KCNE1",
        "hgnc": "HGNC:6240",
        "name": "potassium voltage-gated channel subfamily E regulatory subunit 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcne1"
      },
      {
        "slug": "alpk3",
        "symbol": "ALPK3",
        "hgnc": "HGNC:17574",
        "name": "alpha kinase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alpk3"
      },
      {
        "slug": "kcna5",
        "symbol": "KCNA5",
        "hgnc": "HGNC:6224",
        "name": "potassium voltage-gated channel subfamily A member 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcna5"
      },
      {
        "slug": "kcnj2",
        "symbol": "KCNJ2",
        "hgnc": "HGNC:6263",
        "name": "potassium inwardly rectifying channel subfamily J member 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcnj2"
      },
      {
        "slug": "kcnj5",
        "symbol": "KCNJ5",
        "hgnc": "HGNC:6266",
        "name": "potassium inwardly rectifying channel subfamily J member 5",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcnj5"
      },
      {
        "slug": "tafazzin",
        "symbol": "TAFAZZIN",
        "hgnc": "HGNC:11577",
        "name": "tafazzin, phospholipid-lysophospholipid transacylase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tafazzin"
      },
      {
        "slug": "tango2",
        "symbol": "TANGO2",
        "hgnc": "HGNC:25439",
        "name": "transport and golgi organization 2 homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tango2"
      },
      {
        "slug": "adamts10",
        "symbol": "ADAMTS10",
        "hgnc": "HGNC:13201",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts10"
      },
      {
        "slug": "adamts17",
        "symbol": "ADAMTS17",
        "hgnc": "HGNC:17109",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 17",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts17"
      },
      {
        "slug": "fbn1",
        "symbol": "FBN1",
        "hgnc": "HGNC:3603",
        "name": "fibrillin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbn1"
      },
      {
        "slug": "flnc",
        "symbol": "FLNC",
        "hgnc": "HGNC:3756",
        "name": "filamin C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flnc"
      },
      {
        "slug": "hcn4",
        "symbol": "HCN4",
        "hgnc": "HGNC:16882",
        "name": "hyperpolarization activated cyclic nucleotide gated potassium channel 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hcn4"
      },
      {
        "slug": "ltbp2",
        "symbol": "LTBP2",
        "hgnc": "HGNC:6715",
        "name": "latent transforming growth factor beta binding protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ltbp2"
      },
      {
        "slug": "svil",
        "symbol": "SVIL",
        "hgnc": "HGNC:11480",
        "name": "supervillin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/svil"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "tnni3k",
        "symbol": "TNNI3K",
        "hgnc": "HGNC:19661",
        "name": "TNNI3 interacting kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnni3k"
      }
    ]
  }
}