{
  "url": "https://dantelabs.com/traits/intestinal-perforation",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "intestinal-perforation",
    "id": "HP:0031368",
    "name": "Intestinal perforation",
    "definition": "A hole (perforation) in the wall of the intestine.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-intestine-morphology",
        "name": "Abnormality of the intestine",
        "url": "https://dantelabs.com/traits/abnormal-intestine-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "colon-perforation",
        "name": "Colon perforation",
        "genes": 16,
        "url": "https://dantelabs.com/traits/colon-perforation"
      }
    ],
    "genes": [
      {
        "slug": "b2m",
        "symbol": "B2M",
        "hgnc": "HGNC:914",
        "name": "beta-2-microglobulin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b2m"
      },
      {
        "slug": "stat3",
        "symbol": "STAT3",
        "hgnc": "HGNC:11364",
        "name": "signal transducer and activator of transcription 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat3"
      },
      {
        "slug": "tnxb",
        "symbol": "TNXB",
        "hgnc": "HGNC:11976",
        "name": "tenascin XB",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnxb"
      },
      {
        "slug": "c1r",
        "symbol": "C1R",
        "hgnc": "HGNC:1246",
        "name": "complement C1r",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1r"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "tymp",
        "symbol": "TYMP",
        "hgnc": "HGNC:3148",
        "name": "thymidine phosphorylase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tymp"
      }
    ]
  }
}