{
  "url": "https://dantelabs.com/traits/infectious-encephalitis",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "infectious-encephalitis",
    "id": "HP:0002383",
    "name": "Brain inflammation",
    "label": "Infectious encephalitis",
    "definition": "A disorder of the brain caused by an infectious agent that presents with fever, headache, and an altered level of consciousness. There may also be focal or multifocal neurologic deficits, and focal or generalized seizure activity.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      },
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "unusual-cns-infection",
        "name": "Central nervous system infection",
        "url": "https://dantelabs.com/traits/unusual-cns-infection"
      }
    ],
    "narrower": [
      {
        "slug": "viral-encephalitis",
        "name": "Viral encephalitis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/viral-encephalitis"
      }
    ],
    "genes": [
      {
        "slug": "bcl10",
        "symbol": "BCL10",
        "hgnc": "HGNC:989",
        "name": "BCL10 immune signaling adaptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcl10"
      },
      {
        "slug": "l2hgdh",
        "symbol": "L2HGDH",
        "hgnc": "HGNC:20499",
        "name": "L-2-hydroxyglutarate dehydrogenase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/l2hgdh"
      },
      {
        "slug": "tmem70",
        "symbol": "TMEM70",
        "hgnc": "HGNC:26050",
        "name": "transmembrane protein 70",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem70"
      },
      {
        "slug": "atrx",
        "symbol": "ATRX",
        "hgnc": "HGNC:886",
        "name": "ATRX chromatin remodeler",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atrx"
      },
      {
        "slug": "c4a",
        "symbol": "C4A",
        "hgnc": "HGNC:1323",
        "name": "complement C4A (Chido/Rodgers blood group)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c4a"
      },
      {
        "slug": "ccr1",
        "symbol": "CCR1",
        "hgnc": "HGNC:1602",
        "name": "C-C motif chemokine receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccr1"
      },
      {
        "slug": "cd4",
        "symbol": "CD4",
        "hgnc": "HGNC:1678",
        "name": "CD4 molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd4"
      },
      {
        "slug": "cltrn",
        "symbol": "CLTRN",
        "hgnc": "HGNC:29437",
        "name": "collectrin, amino acid transport regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cltrn"
      },
      {
        "slug": "erap1",
        "symbol": "ERAP1",
        "hgnc": "HGNC:18173",
        "name": "endoplasmic reticulum aminopeptidase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erap1"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "hgnc": "HGNC:11920",
        "name": "Fas cell surface death receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fas"
      },
      {
        "slug": "hla-b",
        "symbol": "HLA-B",
        "hgnc": "HGNC:4932",
        "name": "major histocompatibility complex, class I, B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-b"
      },
      {
        "slug": "ifngr1",
        "symbol": "IFNGR1",
        "hgnc": "HGNC:5439",
        "name": "interferon gamma receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifngr1"
      },
      {
        "slug": "il10",
        "symbol": "IL10",
        "hgnc": "HGNC:5962",
        "name": "interleukin 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il10"
      },
      {
        "slug": "il12a",
        "symbol": "IL12A",
        "hgnc": "HGNC:5969",
        "name": "interleukin 12A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12a"
      },
      {
        "slug": "il12a-as1",
        "symbol": "IL12A-AS1",
        "hgnc": "HGNC:49094",
        "name": "IL12A antisense RNA 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12a-as1"
      },
      {
        "slug": "il23r",
        "symbol": "IL23R",
        "hgnc": "HGNC:19100",
        "name": "interleukin 23 receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il23r"
      },
      {
        "slug": "irf4",
        "symbol": "IRF4",
        "hgnc": "HGNC:6119",
        "name": "interferon regulatory factor 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf4"
      },
      {
        "slug": "klrc4",
        "symbol": "KLRC4",
        "hgnc": "HGNC:6377",
        "name": "killer cell lectin like receptor C4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klrc4"
      },
      {
        "slug": "lbr",
        "symbol": "LBR",
        "hgnc": "HGNC:6518",
        "name": "lamin B receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lbr"
      },
      {
        "slug": "mefv",
        "symbol": "MEFV",
        "hgnc": "HGNC:6998",
        "name": "MEFV innate immunity regulator, pyrin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mefv"
      },
      {
        "slug": "prf1",
        "symbol": "PRF1",
        "hgnc": "HGNC:9360",
        "name": "perforin 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/prf1"
      },
      {
        "slug": "slc6a19",
        "symbol": "SLC6A19",
        "hgnc": "HGNC:27960",
        "name": "solute carrier family 6 member 19",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a19"
      },
      {
        "slug": "stat1",
        "symbol": "STAT1",
        "hgnc": "HGNC:11362",
        "name": "signal transducer and activator of transcription 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat1"
      },
      {
        "slug": "stat4",
        "symbol": "STAT4",
        "hgnc": "HGNC:11365",
        "name": "signal transducer and activator of transcription 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat4"
      },
      {
        "slug": "stx11",
        "symbol": "STX11",
        "hgnc": "HGNC:11429",
        "name": "syntaxin 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stx11"
      },
      {
        "slug": "stxbp2",
        "symbol": "STXBP2",
        "hgnc": "HGNC:11445",
        "name": "syntaxin binding protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stxbp2"
      },
      {
        "slug": "tlr4",
        "symbol": "TLR4",
        "hgnc": "HGNC:11850",
        "name": "toll like receptor 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tlr4"
      },
      {
        "slug": "ubac2",
        "symbol": "UBAC2",
        "hgnc": "HGNC:20486",
        "name": "UBA domain containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubac2"
      },
      {
        "slug": "unc13d",
        "symbol": "UNC13D",
        "hgnc": "HGNC:23147",
        "name": "unc-13 homolog D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc13d"
      },
      {
        "slug": "btk",
        "symbol": "BTK",
        "hgnc": "HGNC:1133",
        "name": "Bruton tyrosine kinase",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/btk"
      },
      {
        "slug": "ciita",
        "symbol": "CIITA",
        "hgnc": "HGNC:7067",
        "name": "class II major histocompatibility complex transactivator",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ciita"
      },
      {
        "slug": "sh2d1a",
        "symbol": "SH2D1A",
        "hgnc": "HGNC:10820",
        "name": "SH2 domain containing 1A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh2d1a"
      },
      {
        "slug": "xiap",
        "symbol": "XIAP",
        "hgnc": "HGNC:592",
        "name": "X-linked inhibitor of apoptosis",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xiap"
      }
    ]
  }
}