{
  "url": "https://dantelabs.com/traits/hypoplastic-sacrum",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypoplastic-sacrum",
    "id": "HP:0004590",
    "name": "Small sacrum",
    "label": "Hypoplastic sacrum",
    "definition": "A developmental defect characterized by undergrowth of the sacrum, which is a large, triangular bone at the base of the spine that forms by the fusing of the sacral vertebrae (S1-S5).",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "aplasia-hypoplasia-of-the-sacrum",
        "name": "Absent/small sacrum",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-sacrum"
      }
    ],
    "narrower": [
      {
        "slug": "hypoplastic-sacral-vertebrae",
        "name": "Hypoplastic sacral vertebrae",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hypoplastic-sacral-vertebrae"
      }
    ],
    "genes": [
      {
        "slug": "trip11",
        "symbol": "TRIP11",
        "hgnc": "HGNC:12305",
        "name": "thyroid hormone receptor interactor 11",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trip11"
      },
      {
        "slug": "faap100",
        "symbol": "FAAP100",
        "hgnc": "HGNC:26171",
        "name": "FA core complex associated protein 100",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faap100"
      },
      {
        "slug": "fancl",
        "symbol": "FANCL",
        "hgnc": "HGNC:20748",
        "name": "FA complementation group L",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancl"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp63"
      },
      {
        "slug": "poc1a",
        "symbol": "POC1A",
        "hgnc": "HGNC:24488",
        "name": "POC1 centriolar protein A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/poc1a"
      },
      {
        "slug": "ror2",
        "symbol": "ROR2",
        "hgnc": "HGNC:10257",
        "name": "ROR family WNT receptor 2",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ror2"
      }
    ]
  }
}