{
  "url": "https://dantelabs.com/traits/hypersplenism",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypersplenism",
    "id": "HP:0001971",
    "name": "Hypersplenism",
    "definition": "A malfunctioning of the spleen in which it prematurely destroys red blood cells.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-spleen-physiology",
        "name": "Abnormal spleen physiology",
        "url": "https://dantelabs.com/traits/abnormal-spleen-physiology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cilk1",
        "symbol": "CILK1",
        "hgnc": "HGNC:21219",
        "name": "ciliogenesis associated kinase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cilk1"
      },
      {
        "slug": "itch",
        "symbol": "ITCH",
        "hgnc": "HGNC:13890",
        "name": "itchy E3 ubiquitin protein ligase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/itch"
      },
      {
        "slug": "klf1",
        "symbol": "KLF1",
        "hgnc": "HGNC:6345",
        "name": "KLF transcription factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klf1"
      },
      {
        "slug": "lipa",
        "symbol": "LIPA",
        "hgnc": "HGNC:6617",
        "name": "lipase A, lysosomal acid type",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lipa"
      },
      {
        "slug": "gba1",
        "symbol": "GBA1",
        "hgnc": "HGNC:4177",
        "name": "glucosylceramidase beta 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gba1"
      },
      {
        "slug": "scarb2",
        "symbol": "SCARB2",
        "hgnc": "HGNC:1665",
        "name": "scavenger receptor class B member 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scarb2"
      },
      {
        "slug": "smpd1",
        "symbol": "SMPD1",
        "hgnc": "HGNC:11120",
        "name": "sphingomyelin phosphodiesterase 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/smpd1"
      },
      {
        "slug": "casp10",
        "symbol": "CASP10",
        "hgnc": "HGNC:1500",
        "name": "caspase 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casp10"
      },
      {
        "slug": "dzip1l",
        "symbol": "DZIP1L",
        "hgnc": "HGNC:26551",
        "name": "DAZ interacting zinc finger protein 1 like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dzip1l"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "hgnc": "HGNC:11920",
        "name": "Fas cell surface death receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fas"
      },
      {
        "slug": "faslg",
        "symbol": "FASLG",
        "hgnc": "HGNC:11936",
        "name": "Fas ligand",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faslg"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "pkhd1",
        "symbol": "PKHD1",
        "hgnc": "HGNC:9016",
        "name": "PKHD1 ciliary IPT domain containing fibrocystin/polyductin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkhd1"
      },
      {
        "slug": "psap",
        "symbol": "PSAP",
        "hgnc": "HGNC:9498",
        "name": "prosaposin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psap"
      },
      {
        "slug": "asxl1",
        "symbol": "ASXL1",
        "hgnc": "HGNC:18318",
        "name": "ASXL transcriptional regulator 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asxl1"
      },
      {
        "slug": "cbl",
        "symbol": "CBL",
        "hgnc": "HGNC:1541",
        "name": "Cbl proto-oncogene",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cbl"
      },
      {
        "slug": "med12",
        "symbol": "MED12",
        "hgnc": "HGNC:11957",
        "name": "mediator complex subunit 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med12"
      },
      {
        "slug": "notch1",
        "symbol": "NOTCH1",
        "hgnc": "HGNC:7881",
        "name": "notch receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch1"
      },
      {
        "slug": "runx1",
        "symbol": "RUNX1",
        "hgnc": "HGNC:10471",
        "name": "RUNX family transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/runx1"
      },
      {
        "slug": "srsf2",
        "symbol": "SRSF2",
        "hgnc": "HGNC:10783",
        "name": "serine and arginine rich splicing factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srsf2"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "tulp3",
        "symbol": "TULP3",
        "hgnc": "HGNC:12425",
        "name": "TUB like protein 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tulp3"
      }
    ]
  }
}