{
  "url": "https://dantelabs.com/traits/hypercoagulability",
  "trait": {
    "bundleId": "2026.10.18-e609d43e",
    "release": "2026-09-01",
    "slug": "hypercoagulability",
    "id": "HP:0100724",
    "name": "Hypercoagulability",
    "definition": "An abnormality of coagulation associated with an increased risk of thrombosis.",
    "synonyms": [
      "Blood hyperviscosity",
      "Thrombophilia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-coagulation",
        "name": "Abnormality of coagulation",
        "url": "https://dantelabs.com/traits/abnormality-of-coagulation"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "pros1",
        "symbol": "PROS1",
        "hgnc": "HGNC:9456",
        "name": "protein S",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pros1"
      },
      {
        "slug": "sox17",
        "symbol": "SOX17",
        "hgnc": "HGNC:18122",
        "name": "SRY-box transcription factor 17",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox17"
      },
      {
        "slug": "ank1",
        "symbol": "ANK1",
        "hgnc": "HGNC:492",
        "name": "ankyrin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ank1"
      },
      {
        "slug": "dld",
        "symbol": "DLD",
        "hgnc": "HGNC:2898",
        "name": "dihydrolipoamide dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dld"
      },
      {
        "slug": "epb42",
        "symbol": "EPB42",
        "hgnc": "HGNC:3381",
        "name": "erythrocyte membrane protein band 4.2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epb42"
      },
      {
        "slug": "gata2",
        "symbol": "GATA2",
        "hgnc": "HGNC:4171",
        "name": "GATA binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata2"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "myd88",
        "symbol": "MYD88",
        "hgnc": "HGNC:7562",
        "name": "MYD88 innate immune signal transduction adaptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myd88"
      },
      {
        "slug": "slc4a1",
        "symbol": "SLC4A1",
        "hgnc": "HGNC:11027",
        "name": "solute carrier family 4 member 1 (Diego blood group)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc4a1"
      },
      {
        "slug": "spta1",
        "symbol": "SPTA1",
        "hgnc": "HGNC:11272",
        "name": "spectrin alpha, erythrocytic 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spta1"
      },
      {
        "slug": "sptb",
        "symbol": "SPTB",
        "hgnc": "HGNC:11274",
        "name": "spectrin beta, erythrocytic",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptb"
      },
      {
        "slug": "aggf1",
        "symbol": "AGGF1",
        "hgnc": "HGNC:24684",
        "name": "angiogenic factor with G-patch and FHA domains 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aggf1"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "f5",
        "symbol": "F5",
        "hgnc": "HGNC:3542",
        "name": "coagulation factor V",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f5"
      },
      {
        "slug": "f9",
        "symbol": "F9",
        "hgnc": "HGNC:3551",
        "name": "coagulation factor IX",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f9"
      },
      {
        "slug": "hrg",
        "symbol": "HRG",
        "hgnc": "HGNC:5181",
        "name": "histidine rich glycoprotein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hrg"
      },
      {
        "slug": "proc",
        "symbol": "PROC",
        "hgnc": "HGNC:9451",
        "name": "protein C, inactivator of coagulation factors Va and VIIIa",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/proc"
      },
      {
        "slug": "thbd",
        "symbol": "THBD",
        "hgnc": "HGNC:11784",
        "name": "thrombomodulin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/thbd"
      }
    ]
  }
}