{
  "url": "https://dantelabs.com/traits/generalized-lipodystrophy",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "generalized-lipodystrophy",
    "id": "HP:0009064",
    "name": "Generalized lipodystrophy",
    "definition": "Generalized degenerative changes of the fat tissue.",
    "synonyms": [
      "Generalised lipodystrophy",
      "Lipodystrophy, generalised",
      "Lipodystrophy, generalized"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "lipodystrophy",
        "name": "Inability to make and keep healthy fat tissue",
        "url": "https://dantelabs.com/traits/lipodystrophy"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "bud13",
        "symbol": "BUD13",
        "hgnc": "HGNC:28199",
        "name": "BUD13 spliceosome associated protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bud13"
      },
      {
        "slug": "fbn1",
        "symbol": "FBN1",
        "hgnc": "HGNC:3603",
        "name": "fibrillin 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbn1"
      },
      {
        "slug": "psmg2",
        "symbol": "PSMG2",
        "hgnc": "HGNC:24929",
        "name": "proteasome assembly chaperone 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmg2"
      },
      {
        "slug": "supt7l",
        "symbol": "SUPT7L",
        "hgnc": "HGNC:30632",
        "name": "SPT7 like, STAGA complex subunit gamma",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/supt7l"
      },
      {
        "slug": "bscl2",
        "symbol": "BSCL2",
        "hgnc": "HGNC:15832",
        "name": "BSCL2 lipid droplet biogenesis associated, seipin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bscl2"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "kcnj6",
        "symbol": "KCNJ6",
        "hgnc": "HGNC:6267",
        "name": "potassium inwardly rectifying channel subfamily J member 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj6"
      },
      {
        "slug": "mtx2",
        "symbol": "MTX2",
        "hgnc": "HGNC:7506",
        "name": "metaxin 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtx2"
      },
      {
        "slug": "zmpste24",
        "symbol": "ZMPSTE24",
        "hgnc": "HGNC:12877",
        "name": "zinc metallopeptidase STE24",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/zmpste24"
      },
      {
        "slug": "cav1",
        "symbol": "CAV1",
        "hgnc": "HGNC:1527",
        "name": "caveolin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cav1"
      }
    ]
  }
}