{
  "url": "https://dantelabs.com/traits/decreased-circulating-complement-factor-h-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "decreased-circulating-complement-factor-h-concentration",
    "id": "HP:0005369",
    "name": "Decreased circulating complement factor H concentration",
    "definition": "Concentration of the complement component factor H in the blood circulation below the lower limit of normal.",
    "synonyms": [
      "Decreased serum complement factor H"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "reduced-circulating-complement-concentration",
        "name": "Reduced circulating complement concentration",
        "url": "https://dantelabs.com/traits/reduced-circulating-complement-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cfh",
        "symbol": "CFH",
        "hgnc": "HGNC:4883",
        "name": "complement factor H",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cfh"
      },
      {
        "slug": "cfhr1",
        "symbol": "CFHR1",
        "hgnc": "HGNC:4888",
        "name": "complement factor H related 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfhr1"
      },
      {
        "slug": "cfhr3",
        "symbol": "CFHR3",
        "hgnc": "HGNC:16980",
        "name": "complement factor H related 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfhr3"
      },
      {
        "slug": "cfi",
        "symbol": "CFI",
        "hgnc": "HGNC:5394",
        "name": "complement factor I",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfi"
      }
    ]
  }
}