{
  "url": "https://dantelabs.com/traits/cutaneous-necrosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "cutaneous-necrosis",
    "id": "HP:0033126",
    "name": "Cutaneous necrosis",
    "definition": "Skin and subcutaneous tissue necrosis (tissue death). Clinically, cutaneous necrosis may present as a painful and extremely tender black eschar (dead tissue found in a full-thickness wound) surrounded by dusky grey-red colored skin or as slough (dead tissue, usually cream or yellow in colour).",
    "synonyms": [
      "Skin necrosis",
      "Skin necrotic patch"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "localized-skin-lesion",
        "name": "Localized skin lesion",
        "url": "https://dantelabs.com/traits/localized-skin-lesion"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ada2",
        "symbol": "ADA2",
        "hgnc": "HGNC:1839",
        "name": "adenosine deaminase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ada2"
      }
    ]
  }
}