{
  "url": "https://dantelabs.com/traits/anaphylactic-shock",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "anaphylactic-shock",
    "id": "HP:0100845",
    "name": "Anaphylaxis",
    "label": "Anaphylactic shock",
    "definition": "An acute hypersensitivity reaction due to exposure to a previously encountered antigen.",
    "synonyms": [
      "Anaphylactic reaction",
      "Anaphylactoid-type reaction"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "immunologic-hypersensitivity",
        "name": "Immunologic hypersensitivity",
        "url": "https://dantelabs.com/traits/immunologic-hypersensitivity"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "spink5",
        "symbol": "SPINK5",
        "hgnc": "HGNC:15464",
        "name": "serine peptidase inhibitor Kazal type 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spink5"
      },
      {
        "slug": "asxl1",
        "symbol": "ASXL1",
        "hgnc": "HGNC:18318",
        "name": "ASXL transcriptional regulator 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asxl1"
      },
      {
        "slug": "cbl",
        "symbol": "CBL",
        "hgnc": "HGNC:1541",
        "name": "Cbl proto-oncogene",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cbl"
      },
      {
        "slug": "runx1",
        "symbol": "RUNX1",
        "hgnc": "HGNC:10471",
        "name": "RUNX family transcription factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/runx1"
      },
      {
        "slug": "srsf2",
        "symbol": "SRSF2",
        "hgnc": "HGNC:10783",
        "name": "serine and arginine rich splicing factor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srsf2"
      },
      {
        "slug": "stat6",
        "symbol": "STAT6",
        "hgnc": "HGNC:11368",
        "name": "signal transducer and activator of transcription 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat6"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "dock8",
        "symbol": "DOCK8",
        "hgnc": "HGNC:19191",
        "name": "dedicator of cytokinesis 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock8"
      },
      {
        "slug": "kit",
        "symbol": "KIT",
        "hgnc": "HGNC:6342",
        "name": "KIT proto-oncogene, receptor tyrosine kinase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kit"
      }
    ]
  }
}