{
  "url": "https://dantelabs.com/traits/acute-leukemia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "acute-leukemia",
    "id": "HP:0002488",
    "name": "Acute blood cancer",
    "label": "Acute leukemia",
    "definition": "A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).",
    "synonyms": [
      "Acute leukaemia",
      "Acute leukemias"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "leukemia",
        "name": "Blood cancer",
        "url": "https://dantelabs.com/traits/leukemia"
      }
    ],
    "narrower": [
      {
        "slug": "acute-myeloid-leukemia",
        "name": "Acute myeloid leukemia",
        "genes": 76,
        "url": "https://dantelabs.com/traits/acute-myeloid-leukemia"
      },
      {
        "slug": "acute-lymphoblastic-leukemia",
        "name": "Acute lymphoblastic leukemia",
        "genes": 31,
        "url": "https://dantelabs.com/traits/acute-lymphoblastic-leukemia"
      },
      {
        "slug": "acute-monocytic-leukemia",
        "name": "Acute monocytic leukemia",
        "genes": 3,
        "url": "https://dantelabs.com/traits/acute-monocytic-leukemia"
      },
      {
        "slug": "acute-myelomonocytic-leukemia",
        "name": "Acute myelomonocytic leukemia",
        "genes": 2,
        "url": "https://dantelabs.com/traits/acute-myelomonocytic-leukemia"
      },
      {
        "slug": "acute-promyelocytic-leukemia",
        "name": "Acute promyelocytic leukemia",
        "genes": 2,
        "url": "https://dantelabs.com/traits/acute-promyelocytic-leukemia"
      }
    ],
    "genes": [
      {
        "slug": "gata2",
        "symbol": "GATA2",
        "hgnc": "HGNC:4171",
        "name": "GATA binding protein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata2"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/jak2"
      },
      {
        "slug": "lig4",
        "symbol": "LIG4",
        "hgnc": "HGNC:6601",
        "name": "DNA ligase 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lig4"
      },
      {
        "slug": "atrx",
        "symbol": "ATRX",
        "hgnc": "HGNC:886",
        "name": "ATRX chromatin remodeler",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atrx"
      },
      {
        "slug": "calr",
        "symbol": "CALR",
        "hgnc": "HGNC:1455",
        "name": "calreticulin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calr"
      },
      {
        "slug": "dync2li1",
        "symbol": "DYNC2LI1",
        "hgnc": "HGNC:24595",
        "name": "dynein cytoplasmic 2 light intermediate chain 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync2li1"
      },
      {
        "slug": "evc",
        "symbol": "EVC",
        "hgnc": "HGNC:3497",
        "name": "EvC ciliary complex subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/evc"
      },
      {
        "slug": "evc2",
        "symbol": "EVC2",
        "hgnc": "HGNC:19747",
        "name": "EvC ciliary complex subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/evc2"
      },
      {
        "slug": "gli1",
        "symbol": "GLI1",
        "hgnc": "HGNC:4317",
        "name": "GLI family zinc finger 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gli1"
      },
      {
        "slug": "mpl",
        "symbol": "MPL",
        "hgnc": "HGNC:7217",
        "name": "MPL proto-oncogene, thrombopoietin receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpl"
      },
      {
        "slug": "nbn",
        "symbol": "NBN",
        "hgnc": "HGNC:7652",
        "name": "nibrin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nbn"
      },
      {
        "slug": "pigl",
        "symbol": "PIGL",
        "hgnc": "HGNC:8966",
        "name": "phosphatidylinositol glycan anchor biosynthesis class L",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigl"
      },
      {
        "slug": "prkaca",
        "symbol": "PRKACA",
        "hgnc": "HGNC:9380",
        "name": "protein kinase cAMP-activated catalytic subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkaca"
      },
      {
        "slug": "prkacb",
        "symbol": "PRKACB",
        "hgnc": "HGNC:9381",
        "name": "protein kinase cAMP-activated catalytic subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkacb"
      },
      {
        "slug": "sh2b3",
        "symbol": "SH2B3",
        "hgnc": "HGNC:29605",
        "name": "SH2B adaptor protein 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh2b3"
      },
      {
        "slug": "sts",
        "symbol": "STS",
        "hgnc": "HGNC:11425",
        "name": "steroid sulfatase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sts"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "tp53",
        "symbol": "TP53",
        "hgnc": "HGNC:11998",
        "name": "tumor protein p53",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tp53"
      },
      {
        "slug": "trem2",
        "symbol": "TREM2",
        "hgnc": "HGNC:17761",
        "name": "triggering receptor expressed on myeloid cells 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trem2"
      },
      {
        "slug": "tyrobp",
        "symbol": "TYROBP",
        "hgnc": "HGNC:12449",
        "name": "transmembrane immune signaling adaptor TYROBP",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tyrobp"
      },
      {
        "slug": "was",
        "symbol": "WAS",
        "hgnc": "HGNC:12731",
        "name": "WASP actin nucleation promoting factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/was"
      }
    ]
  }
}