{
  "url": "https://dantelabs.com/traits/abnormal-peripheral-myelination",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-peripheral-myelination",
    "id": "HP:0003130",
    "name": "Abnormal peripheral myelination",
    "definition": "An abnormality of the myelination of motor and sensory peripheral nerves. These are axons for motor nerves and dendrites for sensory nerves in the strict anatomic sense.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-myelination",
        "name": "Abnormal myelination",
        "url": "https://dantelabs.com/traits/abnormal-myelination"
      },
      {
        "slug": "abnormal-peripheral-nervous-system-morphology",
        "name": "Abnormal peripheral nervous system structure",
        "url": "https://dantelabs.com/traits/abnormal-peripheral-nervous-system-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "decreased-number-of-peripheral-myelinated-nerve-fibers",
        "name": "Decreased number of peripheral myelinated nerve fibers",
        "genes": 35,
        "url": "https://dantelabs.com/traits/decreased-number-of-peripheral-myelinated-nerve-fibers"
      },
      {
        "slug": "peripheral-demyelination",
        "name": "Peripheral demyelination",
        "genes": 35,
        "url": "https://dantelabs.com/traits/peripheral-demyelination"
      },
      {
        "slug": "onion-bulb-formation",
        "name": "Onion bulb formation",
        "genes": 30,
        "url": "https://dantelabs.com/traits/onion-bulb-formation"
      },
      {
        "slug": "peripheral-hypomyelination",
        "name": "Peripheral hypomyelination",
        "genes": 10,
        "url": "https://dantelabs.com/traits/peripheral-hypomyelination"
      },
      {
        "slug": "peripheral-dysmyelination",
        "name": "Peripheral dysmyelination",
        "genes": 4,
        "url": "https://dantelabs.com/traits/peripheral-dysmyelination"
      },
      {
        "slug": "delayed-peripheral-myelination",
        "name": "Delayed peripheral myelination",
        "genes": 2,
        "url": "https://dantelabs.com/traits/delayed-peripheral-myelination"
      },
      {
        "slug": "peripheral-hypermyelination",
        "name": "Peripheral hypermyelination",
        "genes": 0,
        "url": "https://dantelabs.com/traits/peripheral-hypermyelination"
      }
    ],
    "genes": [
      {
        "slug": "dhh",
        "symbol": "DHH",
        "hgnc": "HGNC:2865",
        "name": "desert hedgehog signaling molecule",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhh"
      },
      {
        "slug": "morc2",
        "symbol": "MORC2",
        "hgnc": "HGNC:23573",
        "name": "MORC family CW-type zinc finger 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/morc2"
      },
      {
        "slug": "ercc6",
        "symbol": "ERCC6",
        "hgnc": "HGNC:3438",
        "name": "ERCC excision repair 6, chromatin remodeling factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc6"
      },
      {
        "slug": "ercc8",
        "symbol": "ERCC8",
        "hgnc": "HGNC:3439",
        "name": "ERCC excision repair 8, CSA ubiquitin ligase complex subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc8"
      }
    ]
  }
}