{
  "url": "https://dantelabs.com/traits/abnormal-neuron-morphology",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "abnormal-neuron-morphology",
    "id": "HP:0012757",
    "name": "Abnormal neuron shape",
    "label": "Abnormal neuron morphology",
    "definition": "A structural anomaly of a neuron. Neurons are electrically excitable cells that transmit signals throughout the body. Neurons employ both electrical and chemical components in the transmission of information. Neurons are connected to other neurons at synapses and connected to effector organs or cells at neuroeffector junctions.",
    "synonyms": [
      "Abnormal neuronal morphology"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-nervous-system-morphology",
        "name": "Abnormal shape of nervous system",
        "url": "https://dantelabs.com/traits/abnormal-nervous-system-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-motor-neuron-morphology",
        "name": "Abnormal shape of motor neuron",
        "genes": 3,
        "url": "https://dantelabs.com/traits/abnormal-motor-neuron-morphology"
      },
      {
        "slug": "axonal-spheroids",
        "name": "Axonal spheroids",
        "genes": 1,
        "url": "https://dantelabs.com/traits/axonal-spheroids"
      },
      {
        "slug": "eosinophilic-neuronal-inclusion-bodies",
        "name": "Eosinophilic neuronal inclusion bodies",
        "genes": 1,
        "url": "https://dantelabs.com/traits/eosinophilic-neuronal-inclusion-bodies"
      },
      {
        "slug": "multinucleated-neuron",
        "name": "Multinucleated neuron",
        "genes": 1,
        "url": "https://dantelabs.com/traits/multinucleated-neuron"
      }
    ],
    "genes": [
      {
        "slug": "cntnap2",
        "symbol": "CNTNAP2",
        "hgnc": "HGNC:13830",
        "name": "contactin associated protein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cntnap2"
      },
      {
        "slug": "prkar1b",
        "symbol": "PRKAR1B",
        "hgnc": "HGNC:9390",
        "name": "protein kinase cAMP-dependent type I regulatory subunit beta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1b"
      },
      {
        "slug": "znf335",
        "symbol": "ZNF335",
        "hgnc": "HGNC:15807",
        "name": "zinc finger protein 335",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf335"
      },
      {
        "slug": "akt3",
        "symbol": "AKT3",
        "hgnc": "HGNC:393",
        "name": "AKT serine/threonine kinase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt3"
      },
      {
        "slug": "mtor",
        "symbol": "MTOR",
        "hgnc": "HGNC:3942",
        "name": "mechanistic target of rapamycin kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtor"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3ca"
      }
    ]
  }
}