{
  "url": "https://dantelabs.com/traits/abnormal-mandible-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-mandible-morphology",
    "id": "HP:0000277",
    "name": "Abnormality of the lower jaw bone",
    "label": "Abnormal mandible morphology",
    "definition": "Any abnormality of the mandible, the bone of the lower jaw.",
    "synonyms": [
      "Abnormality of the mandible",
      "Deformity of the lower jaw bone",
      "Malformation of the lower jaw bone"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-jaw-morphology",
        "name": "Abnormal jaw morphology",
        "url": "https://dantelabs.com/traits/abnormal-jaw-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "retrognathia",
        "name": "Receding chin",
        "genes": 345,
        "url": "https://dantelabs.com/traits/retrognathia"
      },
      {
        "slug": "mandibular-prognathia",
        "name": "Big lower jaw",
        "genes": 226,
        "url": "https://dantelabs.com/traits/mandibular-prognathia"
      },
      {
        "slug": "trismus",
        "name": "Decrease in jaw mobility",
        "genes": 15,
        "url": "https://dantelabs.com/traits/trismus"
      },
      {
        "slug": "abnormality-of-the-temporomandibular-joint",
        "name": "Abnormality of the jaw joint",
        "genes": 14,
        "url": "https://dantelabs.com/traits/abnormality-of-the-temporomandibular-joint"
      },
      {
        "slug": "broad-jaw",
        "name": "Broad jaw",
        "genes": 7,
        "url": "https://dantelabs.com/traits/broad-jaw"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-mandible",
        "name": "Aplasia/Hypoplasia of the mandible",
        "genes": 5,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-mandible"
      },
      {
        "slug": "narrow-jaw",
        "name": "Narrow jaw",
        "genes": 4,
        "url": "https://dantelabs.com/traits/narrow-jaw"
      },
      {
        "slug": "mandibular-osteomyelitis",
        "name": "Lower jaw bone infection",
        "genes": 3,
        "url": "https://dantelabs.com/traits/mandibular-osteomyelitis"
      },
      {
        "slug": "mandibular-pain",
        "name": "Lower jaw pain",
        "genes": 3,
        "url": "https://dantelabs.com/traits/mandibular-pain"
      },
      {
        "slug": "obtuse-angle-of-mandible",
        "name": "Obtuse angle of mandible",
        "genes": 3,
        "url": "https://dantelabs.com/traits/obtuse-angle-of-mandible"
      },
      {
        "slug": "increased-size-of-the-mandible",
        "name": "Increased size of the mandible",
        "genes": 2,
        "url": "https://dantelabs.com/traits/increased-size-of-the-mandible"
      },
      {
        "slug": "fibrous-syngnathia",
        "name": "Fibrous syngnathia",
        "genes": 1,
        "url": "https://dantelabs.com/traits/fibrous-syngnathia"
      },
      {
        "slug": "giant-cell-granuloma-of-mandible",
        "name": "Giant cell granuloma of mandible",
        "genes": 1,
        "url": "https://dantelabs.com/traits/giant-cell-granuloma-of-mandible"
      },
      {
        "slug": "mandibular-osteolysis",
        "name": "Mandibular osteolysis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/mandibular-osteolysis"
      },
      {
        "slug": "recurrent-mandibular-subluxations",
        "name": "Recurrent mandibular subluxations",
        "genes": 1,
        "url": "https://dantelabs.com/traits/recurrent-mandibular-subluxations"
      },
      {
        "slug": "thickened-cortex-of-the-mandible",
        "name": "Thickened cortex of the mandible",
        "genes": 1,
        "url": "https://dantelabs.com/traits/thickened-cortex-of-the-mandible"
      },
      {
        "slug": "abnormal-mandible-condylar-process-morphology",
        "name": "Abnormal mandible condylar process morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-mandible-condylar-process-morphology"
      },
      {
        "slug": "abnormal-mandibular-ramus-morphology",
        "name": "Abnormal mandibular ramus morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-mandibular-ramus-morphology"
      },
      {
        "slug": "midline-defect-of-mandible",
        "name": "Midline defect of mandible",
        "genes": 0,
        "url": "https://dantelabs.com/traits/midline-defect-of-mandible"
      }
    ],
    "genes": [
      {
        "slug": "sh3bp2",
        "symbol": "SH3BP2",
        "hgnc": "HGNC:10825",
        "name": "SH3 domain binding protein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh3bp2"
      },
      {
        "slug": "notch2",
        "symbol": "NOTCH2",
        "hgnc": "HGNC:7882",
        "name": "notch receptor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch2"
      },
      {
        "slug": "pik3r1",
        "symbol": "PIK3R1",
        "hgnc": "HGNC:8979",
        "name": "phosphoinositide-3-kinase regulatory subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3r1"
      }
    ]
  }
}