{
  "url": "https://dantelabs.com/traits/abnormal-lymphocyte-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-lymphocyte-morphology",
    "id": "HP:0004332",
    "name": "Abnormal lymphocyte morphology",
    "definition": "An abnormality of lymphocytes.",
    "synonyms": [
      "Abnormal lymphocytes",
      "Abnormality of cells of the lymphoid lineage"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-leukocyte-morphology",
        "name": "Abnormal leukocyte morphology",
        "url": "https://dantelabs.com/traits/abnormal-leukocyte-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "vacuolated-lymphocytes",
        "name": "Vacuolated lymphocytes",
        "genes": 9,
        "url": "https://dantelabs.com/traits/vacuolated-lymphocytes"
      },
      {
        "slug": "abnormal-t-cell-morphology",
        "name": "Abnormal T cell morphology",
        "genes": 6,
        "url": "https://dantelabs.com/traits/abnormal-t-cell-morphology"
      },
      {
        "slug": "abnormal-lymphocyte-count",
        "name": "Abnormal lymphocyte count",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-lymphocyte-count"
      },
      {
        "slug": "abnormal-b-cell-morphology",
        "name": "Abnormal B cell morphology",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-b-cell-morphology"
      },
      {
        "slug": "abnormal-natural-killer-cell-morphology",
        "name": "Abnormal natural killer cell morphology",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-natural-killer-cell-morphology"
      },
      {
        "slug": "absent-microvilli-on-the-surface-of-peripheral-blood-lymphocytes",
        "name": "Absent microvilli on the surface of peripheral blood lymphocytes",
        "genes": 1,
        "url": "https://dantelabs.com/traits/absent-microvilli-on-the-surface-of-peripheral-blood-lymphocytes"
      }
    ],
    "genes": [
      {
        "slug": "ada",
        "symbol": "ADA",
        "hgnc": "HGNC:186",
        "name": "adenosine deaminase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ada"
      },
      {
        "slug": "cd28",
        "symbol": "CD28",
        "hgnc": "HGNC:1653",
        "name": "CD28 molecule",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cd28"
      },
      {
        "slug": "chd7",
        "symbol": "CHD7",
        "hgnc": "HGNC:20626",
        "name": "chromodomain helicase DNA binding protein 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd7"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "hgnc": "HGNC:2505",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ctla4"
      },
      {
        "slug": "dclre1c",
        "symbol": "DCLRE1C",
        "hgnc": "HGNC:17642",
        "name": "DNA cross-link repair 1C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dclre1c"
      },
      {
        "slug": "il2rg",
        "symbol": "IL2RG",
        "hgnc": "HGNC:6010",
        "name": "interleukin 2 receptor subunit gamma",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il2rg"
      },
      {
        "slug": "il7r",
        "symbol": "IL7R",
        "hgnc": "HGNC:6024",
        "name": "interleukin 7 receptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il7r"
      },
      {
        "slug": "nudcd3",
        "symbol": "NUDCD3",
        "hgnc": "HGNC:22208",
        "name": "NudC domain containing 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nudcd3"
      },
      {
        "slug": "psmb10",
        "symbol": "PSMB10",
        "hgnc": "HGNC:9538",
        "name": "proteasome 20S subunit beta 10",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmb10"
      },
      {
        "slug": "rag1",
        "symbol": "RAG1",
        "hgnc": "HGNC:9831",
        "name": "recombination activating 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rag1"
      },
      {
        "slug": "rag2",
        "symbol": "RAG2",
        "hgnc": "HGNC:9832",
        "name": "recombination activating 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rag2"
      },
      {
        "slug": "rmrp",
        "symbol": "RMRP",
        "hgnc": "HGNC:10031",
        "name": "RNA component of mitochondrial RNA processing endoribonuclease",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rmrp"
      },
      {
        "slug": "tnfrsf1b",
        "symbol": "TNFRSF1B",
        "hgnc": "HGNC:11917",
        "name": "TNF receptor superfamily member 1B",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tnfrsf1b"
      },
      {
        "slug": "nfkb2",
        "symbol": "NFKB2",
        "hgnc": "HGNC:7795",
        "name": "nuclear factor kappa B subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfkb2"
      },
      {
        "slug": "tnfrsf13b",
        "symbol": "TNFRSF13B",
        "hgnc": "HGNC:18153",
        "name": "TNF receptor superfamily member 13B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf13b"
      }
    ]
  }
}