{
  "url": "https://dantelabs.com/traits/abnormal-humerus-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-humerus-morphology",
    "id": "HP:0031095",
    "name": "Abnormal humerus morphology",
    "definition": "Any structural anomaly of the structure of the humerus (i.e., upper arm bone).",
    "synonyms": [
      "Abnormality of the humerus"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-upper-limb-bone-morphology",
        "name": "Abnormal shape of bones of the upper limbs",
        "url": "https://dantelabs.com/traits/abnormal-upper-limb-bone-morphology"
      },
      {
        "slug": "abnormal-long-bone-morphology",
        "name": "Abnormal shape of long bone",
        "url": "https://dantelabs.com/traits/abnormal-long-bone-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "humeroradial-synostosis",
        "name": "Fusion of upper and lower arm bones",
        "genes": 11,
        "url": "https://dantelabs.com/traits/humeroradial-synostosis"
      },
      {
        "slug": "bowed-humerus",
        "name": "Bowed long bone in upper arm",
        "genes": 10,
        "url": "https://dantelabs.com/traits/bowed-humerus"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-humerus",
        "name": "Absent/small long bone in upper arm",
        "genes": 2,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-humerus"
      },
      {
        "slug": "angulated-humerus",
        "name": "Angulated long bone in upper arm",
        "genes": 2,
        "url": "https://dantelabs.com/traits/angulated-humerus"
      },
      {
        "slug": "abnormal-humeral-metaphysis-morphology",
        "name": "Abnormality of the wide portion of the long bone in upper arm",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-humeral-metaphysis-morphology"
      },
      {
        "slug": "humeral-pseudarthrosis",
        "name": "False joint (long bone in upper arm)",
        "genes": 1,
        "url": "https://dantelabs.com/traits/humeral-pseudarthrosis"
      },
      {
        "slug": "scapulohumeral-synostosis",
        "name": "Fusion of shoulder blade to long bone in upper arm",
        "genes": 1,
        "url": "https://dantelabs.com/traits/scapulohumeral-synostosis"
      },
      {
        "slug": "humerus-varus",
        "name": "Humerus varus",
        "genes": 1,
        "url": "https://dantelabs.com/traits/humerus-varus"
      },
      {
        "slug": "bifid-humerus",
        "name": "Notched long bone in upper arm",
        "genes": 1,
        "url": "https://dantelabs.com/traits/bifid-humerus"
      },
      {
        "slug": "tapered-humerus",
        "name": "Tapered long bone of upper arm",
        "genes": 1,
        "url": "https://dantelabs.com/traits/tapered-humerus"
      },
      {
        "slug": "abnormal-humeral-head-morphology",
        "name": "Abnormal head of long bone in upper arm",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-humeral-head-morphology"
      },
      {
        "slug": "abnormal-humeral-ossification",
        "name": "Abnormal maturation of long bone in upper arm",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-humeral-ossification"
      },
      {
        "slug": "abnormal-humeral-epiphysis-morphology",
        "name": "Abnormality of end part of the long bone of the upper arm",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-humeral-epiphysis-morphology"
      },
      {
        "slug": "abnormal-humeral-diaphysis-morphology",
        "name": "Abnormality of shaft of long bone in upper arm",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-humeral-diaphysis-morphology"
      }
    ],
    "genes": [
      {
        "slug": "macroh2a1",
        "symbol": "MACROH2A1",
        "hgnc": "HGNC:4740",
        "name": "macroH2A.1 histone",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/macroh2a1"
      },
      {
        "slug": "pitx1",
        "symbol": "PITX1",
        "hgnc": "HGNC:9004",
        "name": "paired like homeodomain 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pitx1"
      },
      {
        "slug": "shox",
        "symbol": "SHOX",
        "hgnc": "HGNC:10853",
        "name": "SHOX homeobox",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/shox"
      },
      {
        "slug": "tgfb1",
        "symbol": "TGFB1",
        "hgnc": "HGNC:11766",
        "name": "transforming growth factor beta 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfb1"
      },
      {
        "slug": "flnb",
        "symbol": "FLNB",
        "hgnc": "HGNC:3755",
        "name": "filamin B",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/flnb"
      },
      {
        "slug": "tbx3",
        "symbol": "TBX3",
        "hgnc": "HGNC:11602",
        "name": "T-box transcription factor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx3"
      },
      {
        "slug": "tbx5",
        "symbol": "TBX5",
        "hgnc": "HGNC:11604",
        "name": "T-box transcription factor 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx5"
      }
    ]
  }
}