{
  "url": "https://dantelabs.com/traits/abnormal-epidermal-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-epidermal-morphology",
    "id": "HP:0011124",
    "name": "Abnormal epidermal morphology",
    "definition": "An abnormality of the morphology of the epidermis.",
    "synonyms": [
      "Abnormality of epidermal morphology"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-skin-morphology",
        "name": "Abnormal skin structure",
        "url": "https://dantelabs.com/traits/abnormal-skin-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "epidermal-acanthosis",
        "name": "Thickening of upper layer of skin",
        "genes": 58,
        "url": "https://dantelabs.com/traits/epidermal-acanthosis"
      },
      {
        "slug": "scaling-skin",
        "name": "Scaling skin",
        "genes": 45,
        "url": "https://dantelabs.com/traits/scaling-skin"
      },
      {
        "slug": "acantholysis",
        "name": "Acantholysis",
        "genes": 10,
        "url": "https://dantelabs.com/traits/acantholysis"
      },
      {
        "slug": "spongiosis",
        "name": "Spongiosis",
        "genes": 6,
        "url": "https://dantelabs.com/traits/spongiosis"
      },
      {
        "slug": "civatte-bodies",
        "name": "Civatte bodies",
        "genes": 3,
        "url": "https://dantelabs.com/traits/civatte-bodies"
      },
      {
        "slug": "abnormal-epidermal-protein-expression",
        "name": "Abnormal epidermal protein expression",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-epidermal-protein-expression"
      },
      {
        "slug": "abnormal-epidermis-stratum-granulosum-morphology",
        "name": "Abnormal epidermis stratum granulosum morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-epidermis-stratum-granulosum-morphology"
      },
      {
        "slug": "abnormal-keratinocyte-morphology",
        "name": "Abnormal keratinocyte morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-keratinocyte-morphology"
      },
      {
        "slug": "abnormal-rete-ridge-morphology",
        "name": "Abnormal rete ridge morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-rete-ridge-morphology"
      }
    ],
    "genes": [
      {
        "slug": "aagab",
        "symbol": "AAGAB",
        "hgnc": "HGNC:25662",
        "name": "alpha and gamma adaptin binding protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aagab"
      },
      {
        "slug": "col14a1",
        "symbol": "COL14A1",
        "hgnc": "HGNC:2191",
        "name": "collagen type XIV alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col14a1"
      },
      {
        "slug": "lrp1",
        "symbol": "LRP1",
        "hgnc": "HGNC:6692",
        "name": "LDL receptor related protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp1"
      },
      {
        "slug": "cyp26c1",
        "symbol": "CYP26C1",
        "hgnc": "HGNC:20577",
        "name": "cytochrome P450 family 26 subfamily C member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp26c1"
      }
    ]
  }
}