{
  "url": "https://dantelabs.com/traits/abnormal-earlobe-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-earlobe-morphology",
    "id": "HP:0000363",
    "name": "Abnormal earlobe",
    "label": "Abnormal earlobe morphology",
    "definition": "An abnormality of the lobule of pinna.",
    "synonyms": [
      "Abnormality of ear lobe",
      "Abnormality of earlobe",
      "Abnormal lobe of ear",
      "Abnormality of auricular lobule",
      "Abnormality of lobulus auriculae"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-ear",
        "name": "Abnormality of the ear",
        "url": "https://dantelabs.com/traits/abnormality-of-the-ear"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-pinna-morphology",
        "name": "Abnormally shaped ears",
        "url": "https://dantelabs.com/traits/abnormal-pinna-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "large-earlobe",
        "name": "Large earlobe",
        "genes": 47,
        "url": "https://dantelabs.com/traits/large-earlobe"
      },
      {
        "slug": "uplifted-earlobe",
        "name": "Uplifted earlobe",
        "genes": 28,
        "url": "https://dantelabs.com/traits/uplifted-earlobe"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-earlobes",
        "name": "Absent/small ear lobes",
        "genes": 8,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-earlobes"
      },
      {
        "slug": "anterior-creases-of-earlobe",
        "name": "Earlobe crease",
        "genes": 8,
        "url": "https://dantelabs.com/traits/anterior-creases-of-earlobe"
      },
      {
        "slug": "attached-earlobe",
        "name": "Attached earlobe",
        "genes": 7,
        "url": "https://dantelabs.com/traits/attached-earlobe"
      },
      {
        "slug": "cleft-earlobe",
        "name": "Cleft earlobe",
        "genes": 5,
        "url": "https://dantelabs.com/traits/cleft-earlobe"
      },
      {
        "slug": "linear-earlobe-crease",
        "name": "Linear earlobe crease",
        "genes": 1,
        "url": "https://dantelabs.com/traits/linear-earlobe-crease"
      }
    ],
    "genes": [
      {
        "slug": "cul4b",
        "symbol": "CUL4B",
        "hgnc": "HGNC:2555",
        "name": "cullin 4B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cul4b"
      },
      {
        "slug": "hymai",
        "symbol": "HYMAI",
        "hgnc": "HGNC:5326",
        "name": "hydatidiform mole associated and imprinted",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hymai"
      },
      {
        "slug": "plagl1",
        "symbol": "PLAGL1",
        "hgnc": "HGNC:9046",
        "name": "PLAG1 like zinc finger 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plagl1"
      },
      {
        "slug": "atr",
        "symbol": "ATR",
        "hgnc": "HGNC:882",
        "name": "ATR checkpoint kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atr"
      },
      {
        "slug": "atrip",
        "symbol": "ATRIP",
        "hgnc": "HGNC:33499",
        "name": "ATR interacting protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atrip"
      },
      {
        "slug": "bcr",
        "symbol": "BCR",
        "hgnc": "HGNC:1014",
        "name": "BCR activator of RhoGEF and GTPase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcr"
      },
      {
        "slug": "cenpe",
        "symbol": "CENPE",
        "hgnc": "HGNC:1856",
        "name": "centromere protein E",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cenpe"
      },
      {
        "slug": "cep152",
        "symbol": "CEP152",
        "hgnc": "HGNC:29298",
        "name": "centrosomal protein 152",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep152"
      },
      {
        "slug": "cep295",
        "symbol": "CEP295",
        "hgnc": "HGNC:29366",
        "name": "centrosomal protein 295",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep295"
      },
      {
        "slug": "cep63",
        "symbol": "CEP63",
        "hgnc": "HGNC:25815",
        "name": "centrosomal protein 63",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep63"
      },
      {
        "slug": "cpap",
        "symbol": "CPAP",
        "hgnc": "HGNC:17272",
        "name": "centrosome assembly and centriole elongation protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cpap"
      },
      {
        "slug": "crkl",
        "symbol": "CRKL",
        "hgnc": "HGNC:2363",
        "name": "CRK like proto-oncogene, adaptor protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crkl"
      },
      {
        "slug": "dhcr24",
        "symbol": "DHCR24",
        "hgnc": "HGNC:2859",
        "name": "24-dehydrocholesterol reductase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhcr24"
      },
      {
        "slug": "dna2",
        "symbol": "DNA2",
        "hgnc": "HGNC:2939",
        "name": "DNA replication helicase/nuclease 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dna2"
      },
      {
        "slug": "mapk1",
        "symbol": "MAPK1",
        "hgnc": "HGNC:6871",
        "name": "mitogen-activated protein kinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mapk1"
      },
      {
        "slug": "nin",
        "symbol": "NIN",
        "hgnc": "HGNC:14906",
        "name": "ninein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nin"
      },
      {
        "slug": "nsmce2",
        "symbol": "NSMCE2",
        "hgnc": "HGNC:26513",
        "name": "NSE2 SUMO ligase component of SMC5/6 complex",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsmce2"
      },
      {
        "slug": "nup85",
        "symbol": "NUP85",
        "hgnc": "HGNC:8734",
        "name": "nucleoporin 85",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup85"
      },
      {
        "slug": "pcnt",
        "symbol": "PCNT",
        "hgnc": "HGNC:16068",
        "name": "pericentrin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcnt"
      },
      {
        "slug": "plk4",
        "symbol": "PLK4",
        "hgnc": "HGNC:11397",
        "name": "polo like kinase 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plk4"
      },
      {
        "slug": "rbbp8",
        "symbol": "RBBP8",
        "hgnc": "HGNC:9891",
        "name": "RB binding protein 8, endonuclease",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbbp8"
      },
      {
        "slug": "traip",
        "symbol": "TRAIP",
        "hgnc": "HGNC:30764",
        "name": "TRAF interacting protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traip"
      },
      {
        "slug": "cox7b",
        "symbol": "COX7B",
        "hgnc": "HGNC:2291",
        "name": "cytochrome c oxidase subunit 7B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox7b"
      },
      {
        "slug": "hccs",
        "symbol": "HCCS",
        "hgnc": "HGNC:4837",
        "name": "holocytochrome c synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hccs"
      },
      {
        "slug": "mgat2",
        "symbol": "MGAT2",
        "hgnc": "HGNC:7045",
        "name": "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mgat2"
      },
      {
        "slug": "ndufb11",
        "symbol": "NDUFB11",
        "hgnc": "HGNC:20372",
        "name": "NADH:ubiquinone oxidoreductase subunit B11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb11"
      },
      {
        "slug": "por",
        "symbol": "POR",
        "hgnc": "HGNC:9208",
        "name": "cytochrome p450 oxidoreductase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/por"
      },
      {
        "slug": "rac1",
        "symbol": "RAC1",
        "hgnc": "HGNC:9801",
        "name": "Rac family small GTPase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rac1"
      },
      {
        "slug": "slc26a2",
        "symbol": "SLC26A2",
        "hgnc": "HGNC:10994",
        "name": "solute carrier family 26 member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a2"
      }
    ]
  }
}