{
  "url": "https://dantelabs.com/traits/abnormal-circulating-aldosterone-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-aldosterone-concentration",
    "id": "HP:0040085",
    "name": "Abnormal circulating aldosterone",
    "label": "Abnormal circulating aldosterone concentration",
    "synonyms": [
      "Abnormal plasma aldosterone"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-renin-angiotensin-system",
        "name": "Abnormality of renin-angiotensin system",
        "url": "https://dantelabs.com/traits/abnormality-of-renin-angiotensin-system"
      }
    ],
    "narrower": [
      {
        "slug": "increased-circulating-aldosterone-concentration",
        "name": "Elevated plasma aldosterone",
        "genes": 32,
        "url": "https://dantelabs.com/traits/increased-circulating-aldosterone-concentration"
      },
      {
        "slug": "decreased-circulating-aldosterone-concentration",
        "name": "Low blood aldosterone level",
        "genes": 21,
        "url": "https://dantelabs.com/traits/decreased-circulating-aldosterone-concentration"
      }
    ],
    "genes": [
      {
        "slug": "scnn1a",
        "symbol": "SCNN1A",
        "hgnc": "HGNC:10599",
        "name": "sodium channel epithelial 1 subunit alpha",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnn1a"
      },
      {
        "slug": "scnn1b",
        "symbol": "SCNN1B",
        "hgnc": "HGNC:10600",
        "name": "sodium channel epithelial 1 subunit beta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnn1b"
      },
      {
        "slug": "scnn1g",
        "symbol": "SCNN1G",
        "hgnc": "HGNC:10602",
        "name": "sodium channel epithelial 1 subunit gamma",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnn1g"
      },
      {
        "slug": "cdkn1b",
        "symbol": "CDKN1B",
        "hgnc": "HGNC:1785",
        "name": "cyclin dependent kinase inhibitor 1B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn1b"
      },
      {
        "slug": "cdkn2b",
        "symbol": "CDKN2B",
        "hgnc": "HGNC:1788",
        "name": "cyclin dependent kinase inhibitor 2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn2b"
      },
      {
        "slug": "men1",
        "symbol": "MEN1",
        "hgnc": "HGNC:7010",
        "name": "menin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/men1"
      }
    ]
  }
}