{
  "url": "https://dantelabs.com/ko/genes/kremen1",
  "gene": {
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    "symbol": "KREMEN1",
    "name": "kringle containing transmembrane protein 1",
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    "previousSymbols": [
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      "Q96MU8"
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    },
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        {
          "symbol": "TTC28",
          "ensemblId": "ENSG00000100154",
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        {
          "symbol": "CHEK2",
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        {
          "symbol": "HSCB",
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        {
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        {
          "symbol": "XBP1",
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        {
          "symbol": "ZNRF3",
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          "start": 28883537,
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        },
        {
          "symbol": "C22orf31",
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        {
          "symbol": "EMID1",
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        {
          "symbol": "RHBDD3",
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          "biotype": "protein_coding",
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        {
          "symbol": "EWSR1",
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        },
        {
          "symbol": "GAS2L1",
          "ensemblId": "ENSG00000185340",
          "biotype": "protein_coding",
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          "slug": "gas2l1"
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        {
          "symbol": "RASL10A",
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          "slug": "rasl10a"
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        {
          "symbol": "AP1B1",
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        {
          "symbol": "RFPL1",
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        },
        {
          "symbol": "NEFH",
          "ensemblId": "ENSG00000100285",
          "biotype": "protein_coding",
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          "end": 29491390,
          "strand": "+",
          "slug": "nefh"
        },
        {
          "symbol": "THOC5",
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        },
        {
          "symbol": "NIPSNAP1",
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        },
        {
          "symbol": "NF2",
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          "end": 29698598,
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          "slug": "nf2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "ectodermal-dysplasias",
        "name": "외배엽 이형성증",
        "diseases": [
          {
            "mondoId": "MONDO:0044305",
            "name": "외배엽 이형성증 13형, 모발/치아 유형",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "KREMEN1 질환으로, 모발이 성글고 치아가 결손될 수 있습니다.",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/ko/conditions/ectodermal-dysplasias"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "brittle-hair",
        "name": "Brittle hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/brittle-hair"
      },
      {
        "slug": "depressed-nasal-bridge",
        "name": "Depressed nasal bridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/depressed-nasal-bridge"
      },
      {
        "slug": "downslanted-palpebral-fissures",
        "name": "Downward slanting of the opening between the eyelids",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/downslanted-palpebral-fissures"
      },
      {
        "slug": "ectodermal-dysplasia",
        "name": "Ectodermal dysplasia",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ectodermal-dysplasia"
      },
      {
        "slug": "oligodontia",
        "name": "Failure of development of more than six teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/oligodontia"
      },
      {
        "slug": "thick-vermilion-border",
        "name": "Full lips",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thick-vermilion-border"
      },
      {
        "slug": "low-anterior-hairline",
        "name": "Low frontal hairline",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/low-anterior-hairline"
      },
      {
        "slug": "sparse-eyelashes",
        "name": "Sparse eyelashes",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/sparse-eyelashes"
      },
      {
        "slug": "thin-eyebrow",
        "name": "Thin eyebrow",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/thin-eyebrow"
      },
      {
        "slug": "wide-nasal-bridge",
        "name": "Wide nasal bridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/wide-nasal-bridge"
      },
      {
        "slug": "hypertelorism",
        "name": "Wide-set eyes",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypertelorism"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}