{
  "url": "https://dantelabs.com/ko/genes/chrna3",
  "gene": {
    "slug": "chrna3",
    "symbol": "CHRNA3",
    "name": "cholinergic receptor nicotinic alpha 3 subunit",
    "hgnc": "HGNC:1957",
    "summary": null,
    "location": "15q25.1",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [],
    "ensemblId": "ENSG00000080644",
    "entrezId": 1136,
    "omim": [
      "118503"
    ],
    "uniprot": [
      "P32297"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "15",
      "start": 78595309,
      "end": 78620996,
      "strand": "-",
      "ensemblTranscript": "ENST00000326828.6",
      "refseqTranscript": "NM_000743.5",
      "ensemblProtein": "ENSP00000315602.5",
      "refseqProtein": "NP_000734.2",
      "exons": [
        {
          "start": 78595309,
          "end": 78596732
        },
        {
          "start": 78601253,
          "end": 78602264
        },
        {
          "start": 78617024,
          "end": 78617133
        },
        {
          "start": 78618617,
          "end": 78618661
        },
        {
          "start": 78618776,
          "end": 78618915
        },
        {
          "start": 78620713,
          "end": 78620996
        }
      ],
      "cds": {
        "start": 78596604,
        "end": 78620794
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "15",
      "start": 78885394,
      "end": 78913637,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 78108153,
      "end": 79108152,
      "genes": [
        {
          "symbol": "CIB2",
          "ensemblId": "ENSG00000136425",
          "biotype": "protein_coding",
          "start": 78102300,
          "end": 78131565,
          "strand": "-",
          "slug": "cib2"
        },
        {
          "symbol": "IDH3A",
          "ensemblId": "ENSG00000166411",
          "biotype": "protein_coding",
          "start": 78131498,
          "end": 78171945,
          "strand": "+",
          "slug": "idh3a"
        },
        {
          "symbol": "ACSBG1",
          "ensemblId": "ENSG00000103740",
          "biotype": "protein_coding",
          "start": 78167468,
          "end": 78245688,
          "strand": "-",
          "slug": "acsbg1"
        },
        {
          "symbol": "DNAJA4",
          "ensemblId": "ENSG00000140403",
          "biotype": "protein_coding",
          "start": 78264086,
          "end": 78282196,
          "strand": "+",
          "slug": "dnaja4"
        },
        {
          "symbol": "SKIC8",
          "ensemblId": "ENSG00000140395",
          "biotype": "protein_coding",
          "start": 78269375,
          "end": 78306573,
          "strand": "-",
          "slug": "skic8"
        },
        {
          "symbol": "CRABP1",
          "ensemblId": "ENSG00000166426",
          "biotype": "protein_coding",
          "start": 78340260,
          "end": 78348250,
          "strand": "+",
          "slug": "crabp1"
        },
        {
          "symbol": "IREB2",
          "ensemblId": "ENSG00000136381",
          "biotype": "protein_coding",
          "start": 78437431,
          "end": 78501453,
          "strand": "+",
          "slug": "ireb2"
        },
        {
          "symbol": "HYKK",
          "ensemblId": "ENSG00000188266",
          "biotype": "protein_coding",
          "start": 78507383,
          "end": 78537657,
          "strand": "+",
          "slug": "hykk"
        },
        {
          "symbol": "PSMA4",
          "ensemblId": "ENSG00000041357",
          "biotype": "protein_coding",
          "start": 78540089,
          "end": 78560795,
          "strand": "+",
          "slug": "psma4"
        },
        {
          "symbol": "CHRNA5",
          "ensemblId": "ENSG00000169684",
          "biotype": "protein_coding",
          "start": 78565484,
          "end": 78596443,
          "strand": "+",
          "slug": "chrna5"
        },
        {
          "symbol": "CHRNB4",
          "ensemblId": "ENSG00000117971",
          "biotype": "protein_coding",
          "start": 78621941,
          "end": 78727754,
          "strand": "-",
          "slug": "chrnb4"
        },
        {
          "symbol": "ADAMTS7",
          "ensemblId": "ENSG00000136378",
          "biotype": "protein_coding",
          "start": 78759204,
          "end": 78811523,
          "strand": "-",
          "slug": "adamts7"
        },
        {
          "symbol": "MORF4L1",
          "ensemblId": "ENSG00000185787",
          "biotype": "protein_coding",
          "start": 78810487,
          "end": 78903200,
          "strand": "+",
          "slug": "morf4l1"
        },
        {
          "symbol": "CTSH",
          "ensemblId": "ENSG00000103811",
          "biotype": "protein_coding",
          "start": 78921058,
          "end": 78949574,
          "strand": "-",
          "slug": "ctsh"
        },
        {
          "symbol": "RASGRF1",
          "ensemblId": "ENSG00000058335",
          "biotype": "protein_coding",
          "start": 78959906,
          "end": 79090930,
          "strand": "-",
          "slug": "rasgrf1"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "gastroesophageal-reflux",
        "name": "Acid reflux",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gastroesophageal-reflux"
      },
      {
        "slug": "orthostatic-hypotension",
        "name": "Decrease in blood pressure upon standing up",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/orthostatic-hypotension"
      },
      {
        "slug": "failure-to-thrive",
        "name": "Faltering weight",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/failure-to-thrive"
      },
      {
        "slug": "recurrent-urinary-tract-infections",
        "name": "Frequent urinary tract infections",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-urinary-tract-infections"
      },
      {
        "slug": "hydronephrosis",
        "name": "Hydronephrosis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hydronephrosis"
      },
      {
        "slug": "hypospadias",
        "name": "Hypospadias",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypospadias"
      },
      {
        "slug": "neurogenic-bladder",
        "name": "Lack of bladder control due to nervous system injury",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/neurogenic-bladder"
      },
      {
        "slug": "slow-pupillary-light-response",
        "name": "Slow pupillary light response",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/slow-pupillary-light-response"
      },
      {
        "slug": "stage-2-chronic-kidney-disease",
        "name": "Stage 2 chronic kidney disease",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/stage-2-chronic-kidney-disease"
      },
      {
        "slug": "vesicoureteral-reflux",
        "name": "Vesicoureteral reflux",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/vesicoureteral-reflux"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}