{
  "url": "https://dantelabs.com/traits/ventricular-fibrillation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "ventricular-fibrillation",
    "id": "HP:0001663",
    "name": "Ventricular fibrillation",
    "definition": "Uncontrolled contractions of muscles fibers in the left ventricle not producing contraction of the left ventricle. Ventricular fibrillation usually begins with a ventricular premature contraction and a short run of rapid ventricular tachycardia degenerating into uncoordinating ventricular fibrillations.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "ventricular-arrhythmia",
        "name": "Ventricular arrhythmia",
        "url": "https://dantelabs.com/traits/ventricular-arrhythmia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "calm1",
        "symbol": "CALM1",
        "hgnc": "HGNC:1442",
        "name": "calmodulin 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/calm1"
      },
      {
        "slug": "dhcr7",
        "symbol": "DHCR7",
        "hgnc": "HGNC:2860",
        "name": "7-dehydrocholesterol reductase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhcr7"
      },
      {
        "slug": "emd",
        "symbol": "EMD",
        "hgnc": "HGNC:3331",
        "name": "emerin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emd"
      },
      {
        "slug": "gyg1",
        "symbol": "GYG1",
        "hgnc": "HGNC:4699",
        "name": "glycogenin 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gyg1"
      },
      {
        "slug": "hcn4",
        "symbol": "HCN4",
        "hgnc": "HGNC:16882",
        "name": "hyperpolarization activated cyclic nucleotide gated potassium channel 4",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hcn4"
      },
      {
        "slug": "calm2",
        "symbol": "CALM2",
        "hgnc": "HGNC:1445",
        "name": "calmodulin 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calm2"
      },
      {
        "slug": "kcne1",
        "symbol": "KCNE1",
        "hgnc": "HGNC:6240",
        "name": "potassium voltage-gated channel subfamily E regulatory subunit 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcne1"
      },
      {
        "slug": "kcne2",
        "symbol": "KCNE2",
        "hgnc": "HGNC:6242",
        "name": "potassium voltage-gated channel subfamily E regulatory subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcne2"
      },
      {
        "slug": "kcnq1",
        "symbol": "KCNQ1",
        "hgnc": "HGNC:6294",
        "name": "potassium voltage-gated channel subfamily Q member 1",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/kcnq1"
      },
      {
        "slug": "ndufb11",
        "symbol": "NDUFB11",
        "hgnc": "HGNC:20372",
        "name": "NADH:ubiquinone oxidoreductase subunit B11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb11"
      },
      {
        "slug": "scn5a",
        "symbol": "SCN5A",
        "hgnc": "HGNC:10593",
        "name": "sodium voltage-gated channel alpha subunit 5",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/scn5a"
      },
      {
        "slug": "tecrl",
        "symbol": "TECRL",
        "hgnc": "HGNC:27365",
        "name": "trans-2,3-enoyl-CoA reductase like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tecrl"
      },
      {
        "slug": "abcc9",
        "symbol": "ABCC9",
        "hgnc": "HGNC:60",
        "name": "ATP binding cassette subfamily C member 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcc9"
      },
      {
        "slug": "actc1",
        "symbol": "ACTC1",
        "hgnc": "HGNC:143",
        "name": "actin alpha cardiac muscle 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actc1"
      },
      {
        "slug": "akap9",
        "symbol": "AKAP9",
        "hgnc": "HGNC:379",
        "name": "A-kinase anchoring protein 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akap9"
      },
      {
        "slug": "alpk3",
        "symbol": "ALPK3",
        "hgnc": "HGNC:17574",
        "name": "alpha kinase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alpk3"
      },
      {
        "slug": "cacna1c",
        "symbol": "CACNA1C",
        "hgnc": "HGNC:1390",
        "name": "calcium voltage-gated channel subunit alpha1 C",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cacna1c"
      },
      {
        "slug": "cacna1s",
        "symbol": "CACNA1S",
        "hgnc": "HGNC:1397",
        "name": "calcium voltage-gated channel subunit alpha1 S",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1s"
      },
      {
        "slug": "cacna2d1",
        "symbol": "CACNA2D1",
        "hgnc": "HGNC:1399",
        "name": "calcium voltage-gated channel auxiliary subunit alpha2delta 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cacna2d1"
      },
      {
        "slug": "cacnb2",
        "symbol": "CACNB2",
        "hgnc": "HGNC:1402",
        "name": "calcium voltage-gated channel auxiliary subunit beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacnb2"
      },
      {
        "slug": "dsp",
        "symbol": "DSP",
        "hgnc": "HGNC:3052",
        "name": "desmoplakin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsp"
      },
      {
        "slug": "gabra3",
        "symbol": "GABRA3",
        "hgnc": "HGNC:4077",
        "name": "gamma-aminobutyric acid type A receptor subunit alpha3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabra3"
      },
      {
        "slug": "gpd1l",
        "symbol": "GPD1L",
        "hgnc": "HGNC:28956",
        "name": "glycerol-3-phosphate dehydrogenase 1 like",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gpd1l"
      },
      {
        "slug": "kcnd3",
        "symbol": "KCND3",
        "hgnc": "HGNC:6239",
        "name": "potassium voltage-gated channel subfamily D member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnd3"
      },
      {
        "slug": "kcne3",
        "symbol": "KCNE3",
        "hgnc": "HGNC:6243",
        "name": "potassium voltage-gated channel subfamily E regulatory subunit 3",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcne3"
      },
      {
        "slug": "kcne5",
        "symbol": "KCNE5",
        "hgnc": "HGNC:6241",
        "name": "potassium voltage-gated channel subfamily E regulatory subunit 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcne5"
      },
      {
        "slug": "kcnh2",
        "symbol": "KCNH2",
        "hgnc": "HGNC:6251",
        "name": "potassium voltage-gated channel subfamily H member 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcnh2"
      },
      {
        "slug": "kcnj18",
        "symbol": "KCNJ18",
        "hgnc": "HGNC:39080",
        "name": "potassium inwardly rectifying channel subfamily J member 18",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj18"
      },
      {
        "slug": "kcnj2",
        "symbol": "KCNJ2",
        "hgnc": "HGNC:6263",
        "name": "potassium inwardly rectifying channel subfamily J member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj2"
      },
      {
        "slug": "kcnj8",
        "symbol": "KCNJ8",
        "hgnc": "HGNC:6269",
        "name": "potassium inwardly rectifying channel subfamily J member 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj8"
      },
      {
        "slug": "myl2",
        "symbol": "MYL2",
        "hgnc": "HGNC:7583",
        "name": "myosin light chain 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myl2"
      },
      {
        "slug": "pkp2",
        "symbol": "PKP2",
        "hgnc": "HGNC:9024",
        "name": "plakophilin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkp2"
      },
      {
        "slug": "prkag2",
        "symbol": "PRKAG2",
        "hgnc": "HGNC:9386",
        "name": "protein kinase AMP-activated non-catalytic subunit gamma 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkag2"
      },
      {
        "slug": "rangrf",
        "symbol": "RANGRF",
        "hgnc": "HGNC:17679",
        "name": "RAN guanine nucleotide release factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rangrf"
      },
      {
        "slug": "scn10a",
        "symbol": "SCN10A",
        "hgnc": "HGNC:10582",
        "name": "sodium voltage-gated channel alpha subunit 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn10a"
      },
      {
        "slug": "scn1b",
        "symbol": "SCN1B",
        "hgnc": "HGNC:10586",
        "name": "sodium voltage-gated channel beta subunit 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/scn1b"
      },
      {
        "slug": "scn2b",
        "symbol": "SCN2B",
        "hgnc": "HGNC:10589",
        "name": "sodium voltage-gated channel beta subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn2b"
      },
      {
        "slug": "scn3b",
        "symbol": "SCN3B",
        "hgnc": "HGNC:20665",
        "name": "sodium voltage-gated channel beta subunit 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn3b"
      },
      {
        "slug": "scnn1a",
        "symbol": "SCNN1A",
        "hgnc": "HGNC:10599",
        "name": "sodium channel epithelial 1 subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnn1a"
      },
      {
        "slug": "sema3a",
        "symbol": "SEMA3A",
        "hgnc": "HGNC:10723",
        "name": "semaphorin 3A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sema3a"
      },
      {
        "slug": "slc4a3",
        "symbol": "SLC4A3",
        "hgnc": "HGNC:11029",
        "name": "solute carrier family 4 member 3",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc4a3"
      },
      {
        "slug": "slmap",
        "symbol": "SLMAP",
        "hgnc": "HGNC:16643",
        "name": "sarcolemma associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slmap"
      },
      {
        "slug": "trpm4",
        "symbol": "TRPM4",
        "hgnc": "HGNC:17993",
        "name": "transient receptor potential cation channel subfamily M member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpm4"
      },
      {
        "slug": "acadvl",
        "symbol": "ACADVL",
        "hgnc": "HGNC:92",
        "name": "acyl-CoA dehydrogenase very long chain",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acadvl"
      },
      {
        "slug": "clcnkb",
        "symbol": "CLCNKB",
        "hgnc": "HGNC:2027",
        "name": "chloride voltage-gated channel Kb",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcnkb"
      },
      {
        "slug": "slc12a3",
        "symbol": "SLC12A3",
        "hgnc": "HGNC:10912",
        "name": "solute carrier family 12 member 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a3"
      },
      {
        "slug": "alg10b",
        "symbol": "ALG10B",
        "hgnc": "HGNC:31088",
        "name": "ALG10 alpha-1,2-glucosyltransferase B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg10b"
      },
      {
        "slug": "bag5",
        "symbol": "BAG5",
        "hgnc": "HGNC:941",
        "name": "BAG cochaperone 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bag5"
      },
      {
        "slug": "dpp6",
        "symbol": "DPP6",
        "hgnc": "HGNC:3010",
        "name": "dipeptidyl peptidase like 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpp6"
      },
      {
        "slug": "mybpc3",
        "symbol": "MYBPC3",
        "hgnc": "HGNC:7551",
        "name": "myosin binding protein C3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mybpc3"
      },
      {
        "slug": "myl3",
        "symbol": "MYL3",
        "hgnc": "HGNC:7584",
        "name": "myosin light chain 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myl3"
      },
      {
        "slug": "ryr2",
        "symbol": "RYR2",
        "hgnc": "HGNC:10484",
        "name": "ryanodine receptor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ryr2"
      },
      {
        "slug": "snta1",
        "symbol": "SNTA1",
        "hgnc": "HGNC:11167",
        "name": "syntrophin alpha 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snta1"
      },
      {
        "slug": "tango2",
        "symbol": "TANGO2",
        "hgnc": "HGNC:25439",
        "name": "transport and golgi organization 2 homolog",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tango2"
      },
      {
        "slug": "tnnc1",
        "symbol": "TNNC1",
        "hgnc": "HGNC:11943",
        "name": "troponin C1, slow skeletal and cardiac type",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnnc1"
      }
    ]
  }
}