{
  "url": "https://dantelabs.com/traits/ureteral-duplication",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "ureteral-duplication",
    "id": "HP:0000073",
    "name": "Double ureter",
    "label": "Ureteral duplication",
    "definition": "A developmental anomaly characterized by the presence of two, instead of one, ureter connecting a kidney to the bladder.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-ureter-morphology",
        "name": "Abnormal ureter morphology",
        "url": "https://dantelabs.com/traits/abnormal-ureter-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "bifid-ureter",
        "name": "Bifid ureter",
        "genes": 5,
        "url": "https://dantelabs.com/traits/bifid-ureter"
      },
      {
        "slug": "ureter-duplex",
        "name": "Ureter duplex",
        "genes": 1,
        "url": "https://dantelabs.com/traits/ureter-duplex"
      }
    ],
    "genes": [
      {
        "slug": "ift140",
        "symbol": "IFT140",
        "hgnc": "HGNC:29077",
        "name": "intraflagellar transport 140",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift140"
      },
      {
        "slug": "fuz",
        "symbol": "FUZ",
        "hgnc": "HGNC:26219",
        "name": "fuzzy planar cell polarity protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fuz"
      },
      {
        "slug": "gpc3",
        "symbol": "GPC3",
        "hgnc": "HGNC:4451",
        "name": "glypican 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpc3"
      },
      {
        "slug": "gpc4",
        "symbol": "GPC4",
        "hgnc": "HGNC:4452",
        "name": "glypican 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpc4"
      },
      {
        "slug": "ncapg2",
        "symbol": "NCAPG2",
        "hgnc": "HGNC:21904",
        "name": "non-SMC condensin II complex subunit G2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ncapg2"
      },
      {
        "slug": "slc6a17",
        "symbol": "SLC6A17",
        "hgnc": "HGNC:31399",
        "name": "solute carrier family 6 member 17",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc6a17"
      },
      {
        "slug": "vangl1",
        "symbol": "VANGL1",
        "hgnc": "HGNC:15512",
        "name": "VANGL planar cell polarity protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vangl1"
      },
      {
        "slug": "b3glct",
        "symbol": "B3GLCT",
        "hgnc": "HGNC:20207",
        "name": "beta 3-glucosyltransferase",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/b3glct"
      },
      {
        "slug": "b9d1",
        "symbol": "B9D1",
        "hgnc": "HGNC:24123",
        "name": "B9 domain containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b9d1"
      },
      {
        "slug": "b9d2",
        "symbol": "B9D2",
        "hgnc": "HGNC:28636",
        "name": "B9 domain containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b9d2"
      },
      {
        "slug": "cc2d2a",
        "symbol": "CC2D2A",
        "hgnc": "HGNC:29253",
        "name": "coiled-coil and C2 domain containing 2A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cc2d2a"
      },
      {
        "slug": "cep290",
        "symbol": "CEP290",
        "hgnc": "HGNC:29021",
        "name": "centrosomal protein 290",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep290"
      },
      {
        "slug": "cspp1",
        "symbol": "CSPP1",
        "hgnc": "HGNC:26193",
        "name": "centrosome and spindle pole associated protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cspp1"
      },
      {
        "slug": "gata6",
        "symbol": "GATA6",
        "hgnc": "HGNC:4174",
        "name": "GATA binding protein 6",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gata6"
      },
      {
        "slug": "kctd1",
        "symbol": "KCTD1",
        "hgnc": "HGNC:18249",
        "name": "potassium channel tetramerization domain containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kctd1"
      },
      {
        "slug": "kdm6a",
        "symbol": "KDM6A",
        "hgnc": "HGNC:12637",
        "name": "lysine demethylase 6A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6a"
      },
      {
        "slug": "kmt2d",
        "symbol": "KMT2D",
        "hgnc": "HGNC:7133",
        "name": "lysine methyltransferase 2D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2d"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "mks1",
        "symbol": "MKS1",
        "hgnc": "HGNC:7121",
        "name": "MKS transition zone complex subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mks1"
      },
      {
        "slug": "psmd12",
        "symbol": "PSMD12",
        "hgnc": "HGNC:9557",
        "name": "proteasome 26S subunit, non-ATPase 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmd12"
      },
      {
        "slug": "rpgrip1",
        "symbol": "RPGRIP1",
        "hgnc": "HGNC:13436",
        "name": "RPGR interacting protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpgrip1"
      },
      {
        "slug": "rpgrip1l",
        "symbol": "RPGRIP1L",
        "hgnc": "HGNC:29168",
        "name": "RPGRIP1 like",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpgrip1l"
      },
      {
        "slug": "sos1",
        "symbol": "SOS1",
        "hgnc": "HGNC:11187",
        "name": "SOS Ras/Rac guanine nucleotide exchange factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sos1"
      },
      {
        "slug": "spint2",
        "symbol": "SPINT2",
        "hgnc": "HGNC:11247",
        "name": "serine peptidase inhibitor, Kunitz type 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spint2"
      },
      {
        "slug": "tctn1",
        "symbol": "TCTN1",
        "hgnc": "HGNC:26113",
        "name": "tectonic family member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tctn1"
      },
      {
        "slug": "tctn2",
        "symbol": "TCTN2",
        "hgnc": "HGNC:25774",
        "name": "tectonic family member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tctn2"
      },
      {
        "slug": "tctn3",
        "symbol": "TCTN3",
        "hgnc": "HGNC:24519",
        "name": "tectonic family member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tctn3"
      },
      {
        "slug": "tmem107",
        "symbol": "TMEM107",
        "hgnc": "HGNC:28128",
        "name": "transmembrane protein 107",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem107"
      },
      {
        "slug": "tmem216",
        "symbol": "TMEM216",
        "hgnc": "HGNC:25018",
        "name": "transmembrane protein 216",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem216"
      },
      {
        "slug": "tmem231",
        "symbol": "TMEM231",
        "hgnc": "HGNC:37234",
        "name": "transmembrane protein 231",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem231"
      },
      {
        "slug": "tmem237",
        "symbol": "TMEM237",
        "hgnc": "HGNC:14432",
        "name": "transmembrane protein 237",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem237"
      },
      {
        "slug": "tmem67",
        "symbol": "TMEM67",
        "hgnc": "HGNC:28396",
        "name": "transmembrane protein 67",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem67"
      },
      {
        "slug": "txndc15",
        "symbol": "TXNDC15",
        "hgnc": "HGNC:20652",
        "name": "thioredoxin domain containing 15",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/txndc15"
      },
      {
        "slug": "zmpste24",
        "symbol": "ZMPSTE24",
        "hgnc": "HGNC:12877",
        "name": "zinc metallopeptidase STE24",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/zmpste24"
      },
      {
        "slug": "apc2",
        "symbol": "APC2",
        "hgnc": "HGNC:24036",
        "name": "APC regulator of Wnt signaling pathway 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apc2"
      },
      {
        "slug": "nodal",
        "symbol": "NODAL",
        "hgnc": "HGNC:7865",
        "name": "nodal growth differentiation factor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nodal"
      },
      {
        "slug": "nsd1",
        "symbol": "NSD1",
        "hgnc": "HGNC:14234",
        "name": "nuclear receptor binding SET domain protein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsd1"
      },
      {
        "slug": "rbm8a",
        "symbol": "RBM8A",
        "hgnc": "HGNC:9905",
        "name": "RNA binding motif protein 8A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbm8a"
      },
      {
        "slug": "axin1",
        "symbol": "AXIN1",
        "hgnc": "HGNC:903",
        "name": "axin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/axin1"
      },
      {
        "slug": "cpt2",
        "symbol": "CPT2",
        "hgnc": "HGNC:2330",
        "name": "carnitine palmitoyltransferase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cpt2"
      },
      {
        "slug": "pign",
        "symbol": "PIGN",
        "hgnc": "HGNC:8967",
        "name": "phosphatidylinositol glycan anchor biosynthesis class N",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pign"
      },
      {
        "slug": "porcn",
        "symbol": "PORCN",
        "hgnc": "HGNC:17652",
        "name": "porcupine O-acyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/porcn"
      }
    ]
  }
}