{
  "url": "https://dantelabs.com/traits/subcutaneous-calcification",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "subcutaneous-calcification",
    "id": "HP:0007618",
    "name": "Skin calcification",
    "label": "Subcutaneous calcification",
    "definition": "Deposition of calcium salts in subcutaneous tissue (i.e., the the lowermost layer of the integument).",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "ectopic-calcification",
        "name": "Ectopic calcification",
        "url": "https://dantelabs.com/traits/ectopic-calcification"
      },
      {
        "slug": "generalized-abnormality-of-skin",
        "name": "Generalized abnormality of skin",
        "url": "https://dantelabs.com/traits/generalized-abnormality-of-skin"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "fgf23",
        "symbol": "FGF23",
        "hgnc": "HGNC:3680",
        "name": "fibroblast growth factor 23",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf23"
      },
      {
        "slug": "psmc3",
        "symbol": "PSMC3",
        "hgnc": "HGNC:9549",
        "name": "proteasome 26S subunit, ATPase 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmc3"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "wrn",
        "symbol": "WRN",
        "hgnc": "HGNC:12791",
        "name": "WRN RecQ like helicase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wrn"
      }
    ]
  }
}