{
  "url": "https://dantelabs.com/traits/spherocytosis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "spherocytosis",
    "id": "HP:0004444",
    "name": "Spherocytosis",
    "definition": "The presence of erythrocytes that are sphere-shaped.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "poikilocytosis",
        "name": "Poikilocytosis",
        "url": "https://dantelabs.com/traits/poikilocytosis"
      }
    ],
    "narrower": [
      {
        "slug": "microspherocytosis",
        "name": "Microspherocytosis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/microspherocytosis"
      }
    ],
    "genes": [
      {
        "slug": "slc4a1",
        "symbol": "SLC4A1",
        "hgnc": "HGNC:11027",
        "name": "solute carrier family 4 member 1 (Diego blood group)",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/slc4a1"
      },
      {
        "slug": "sptb",
        "symbol": "SPTB",
        "hgnc": "HGNC:11274",
        "name": "spectrin beta, erythrocytic",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sptb"
      },
      {
        "slug": "ank1",
        "symbol": "ANK1",
        "hgnc": "HGNC:492",
        "name": "ankyrin 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ank1"
      },
      {
        "slug": "epb42",
        "symbol": "EPB42",
        "hgnc": "HGNC:3381",
        "name": "erythrocyte membrane protein band 4.2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/epb42"
      },
      {
        "slug": "rhag",
        "symbol": "RHAG",
        "hgnc": "HGNC:10006",
        "name": "Rh associated glycoprotein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhag"
      },
      {
        "slug": "rhce",
        "symbol": "RHCE",
        "hgnc": "HGNC:10008",
        "name": "Rh blood group CcEe antigens",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhce"
      },
      {
        "slug": "rhd",
        "symbol": "RHD",
        "hgnc": "HGNC:10009",
        "name": "Rh blood group D antigen",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhd"
      },
      {
        "slug": "spta1",
        "symbol": "SPTA1",
        "hgnc": "HGNC:11272",
        "name": "spectrin alpha, erythrocytic 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/spta1"
      }
    ]
  }
}