{
  "url": "https://dantelabs.com/traits/short-lower-limbs",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "short-lower-limbs",
    "id": "HP:0006385",
    "name": "Short lower limbs",
    "definition": "Shortening of the legs related to developmental hypoplasia of the bones of the leg.",
    "synonyms": [
      "Short legs"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "lower-limb-undergrowth",
        "name": "Lower limb undergrowth",
        "url": "https://dantelabs.com/traits/lower-limb-undergrowth"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "arl6ip6",
        "symbol": "ARL6IP6",
        "hgnc": "HGNC:24048",
        "name": "ARF like GTPase 6 interacting protein 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arl6ip6"
      },
      {
        "slug": "gna11",
        "symbol": "GNA11",
        "hgnc": "HGNC:4379",
        "name": "G protein subunit alpha 11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gna11"
      },
      {
        "slug": "mmp13",
        "symbol": "MMP13",
        "hgnc": "HGNC:7159",
        "name": "matrix metallopeptidase 13",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/mmp13"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "fn1",
        "symbol": "FN1",
        "hgnc": "HGNC:3778",
        "name": "fibronectin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fn1"
      },
      {
        "slug": "lama5",
        "symbol": "LAMA5",
        "hgnc": "HGNC:6485",
        "name": "laminin subunit alpha 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lama5"
      },
      {
        "slug": "slc26a2",
        "symbol": "SLC26A2",
        "hgnc": "HGNC:10994",
        "name": "solute carrier family 26 member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a2"
      },
      {
        "slug": "adnp",
        "symbol": "ADNP",
        "hgnc": "HGNC:15766",
        "name": "activity dependent neuroprotector homeobox",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adnp"
      },
      {
        "slug": "ext1",
        "symbol": "EXT1",
        "hgnc": "HGNC:3512",
        "name": "exostosin glycosyltransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ext1"
      },
      {
        "slug": "ext2",
        "symbol": "EXT2",
        "hgnc": "HGNC:3513",
        "name": "exostosin glycosyltransferase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ext2"
      },
      {
        "slug": "ptbp1",
        "symbol": "PTBP1",
        "hgnc": "HGNC:9583",
        "name": "polypyrimidine tract binding protein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptbp1"
      },
      {
        "slug": "alpl",
        "symbol": "ALPL",
        "hgnc": "HGNC:438",
        "name": "alkaline phosphatase, biomineralization associated",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alpl"
      },
      {
        "slug": "nog",
        "symbol": "NOG",
        "hgnc": "HGNC:7866",
        "name": "noggin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nog"
      },
      {
        "slug": "ppib",
        "symbol": "PPIB",
        "hgnc": "HGNC:9255",
        "name": "peptidylprolyl isomerase B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppib"
      }
    ]
  }
}