{
  "url": "https://dantelabs.com/traits/raynaud-phenomenon",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "raynaud-phenomenon",
    "id": "HP:0030880",
    "name": "Raynaud phenomenon",
    "synonyms": [
      "Raynaud's phenomenon"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-arterial-physiology",
        "name": "Abnormal arterial physiology",
        "url": "https://dantelabs.com/traits/abnormal-arterial-physiology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "fem1b",
        "symbol": "FEM1B",
        "hgnc": "HGNC:3649",
        "name": "fem-1 homolog B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fem1b"
      },
      {
        "slug": "flna",
        "symbol": "FLNA",
        "hgnc": "HGNC:3754",
        "name": "filamin A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flna"
      },
      {
        "slug": "lbr",
        "symbol": "LBR",
        "hgnc": "HGNC:6518",
        "name": "lamin B receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lbr"
      },
      {
        "slug": "sting1",
        "symbol": "STING1",
        "hgnc": "HGNC:27962",
        "name": "stimulator of interferon response cGAMP interactor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sting1"
      },
      {
        "slug": "trex1",
        "symbol": "TREX1",
        "hgnc": "HGNC:12269",
        "name": "three prime repair exonuclease 1",
        "frequency": "very-frequent",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/trex1"
      },
      {
        "slug": "ada2",
        "symbol": "ADA2",
        "hgnc": "HGNC:1839",
        "name": "adenosine deaminase 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ada2"
      },
      {
        "slug": "apold1",
        "symbol": "APOLD1",
        "hgnc": "HGNC:25268",
        "name": "apolipoprotein L domain containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apold1"
      },
      {
        "slug": "bank1",
        "symbol": "BANK1",
        "hgnc": "HGNC:18233",
        "name": "B cell scaffold protein with ankyrin repeats 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bank1"
      },
      {
        "slug": "blk",
        "symbol": "BLK",
        "hgnc": "HGNC:1057",
        "name": "BLK proto-oncogene, Src family tyrosine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blk"
      },
      {
        "slug": "c4a",
        "symbol": "C4A",
        "hgnc": "HGNC:1323",
        "name": "complement C4A (Chido/Rodgers blood group)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c4a"
      },
      {
        "slug": "c4b",
        "symbol": "C4B",
        "hgnc": "HGNC:1324",
        "name": "complement C4B (Chido/Rodgers blood group)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c4b"
      },
      {
        "slug": "col4a1",
        "symbol": "COL4A1",
        "hgnc": "HGNC:2202",
        "name": "collagen type IV alpha 1 chain",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col4a1"
      },
      {
        "slug": "coq2",
        "symbol": "COQ2",
        "hgnc": "HGNC:25223",
        "name": "coenzyme Q2, polyprenyltransferase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/coq2"
      },
      {
        "slug": "cr2",
        "symbol": "CR2",
        "hgnc": "HGNC:2336",
        "name": "complement C3d receptor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cr2"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "hgnc": "HGNC:2505",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctla4"
      },
      {
        "slug": "dnase1",
        "symbol": "DNASE1",
        "hgnc": "HGNC:2956",
        "name": "deoxyribonuclease 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dnase1"
      },
      {
        "slug": "ets1",
        "symbol": "ETS1",
        "hgnc": "HGNC:3488",
        "name": "ETS proto-oncogene 1, transcription factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ets1"
      },
      {
        "slug": "fcgr2b",
        "symbol": "FCGR2B",
        "hgnc": "HGNC:3618",
        "name": "Fc gamma receptor IIb",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fcgr2b"
      },
      {
        "slug": "fcgr3b",
        "symbol": "FCGR3B",
        "hgnc": "HGNC:3620",
        "name": "Fc gamma receptor IIIb",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcgr3b"
      },
      {
        "slug": "flt3lg",
        "symbol": "FLT3LG",
        "hgnc": "HGNC:3766",
        "name": "fms related receptor tyrosine kinase 3 ligand",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flt3lg"
      },
      {
        "slug": "gucy1a1",
        "symbol": "GUCY1A1",
        "hgnc": "HGNC:4685",
        "name": "guanylate cyclase 1 soluble subunit alpha 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gucy1a1"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "ighg1",
        "symbol": "IGHG1",
        "hgnc": "HGNC:5525",
        "name": "immunoglobulin heavy constant gamma 1 (G1m marker)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ighg1"
      },
      {
        "slug": "il10",
        "symbol": "IL10",
        "hgnc": "HGNC:5962",
        "name": "interleukin 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il10"
      },
      {
        "slug": "irak1",
        "symbol": "IRAK1",
        "hgnc": "HGNC:6112",
        "name": "interleukin 1 receptor associated kinase 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/irak1"
      },
      {
        "slug": "irf5",
        "symbol": "IRF5",
        "hgnc": "HGNC:6120",
        "name": "interferon regulatory factor 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf5"
      },
      {
        "slug": "itgam",
        "symbol": "ITGAM",
        "hgnc": "HGNC:6149",
        "name": "integrin subunit alpha M",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgam"
      },
      {
        "slug": "jazf1",
        "symbol": "JAZF1",
        "hgnc": "HGNC:28917",
        "name": "JAZF zinc finger 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jazf1"
      },
      {
        "slug": "kiaa0319l",
        "symbol": "KIAA0319L",
        "hgnc": "HGNC:30071",
        "name": "KIAA0319 like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kiaa0319l"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "pdcd1",
        "symbol": "PDCD1",
        "hgnc": "HGNC:8760",
        "name": "programmed cell death 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdcd1"
      },
      {
        "slug": "ptpn22",
        "symbol": "PTPN22",
        "hgnc": "HGNC:9652",
        "name": "protein tyrosine phosphatase non-receptor type 22",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn22"
      },
      {
        "slug": "pxk",
        "symbol": "PXK",
        "hgnc": "HGNC:23326",
        "name": "PX domain containing serine/threonine kinase like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pxk"
      },
      {
        "slug": "rnf125",
        "symbol": "RNF125",
        "hgnc": "HGNC:21150",
        "name": "ring finger protein 125",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf125"
      },
      {
        "slug": "spp1",
        "symbol": "SPP1",
        "hgnc": "HGNC:11255",
        "name": "secreted phosphoprotein 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/spp1"
      },
      {
        "slug": "stat4",
        "symbol": "STAT4",
        "hgnc": "HGNC:11365",
        "name": "signal transducer and activator of transcription 4",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/stat4"
      },
      {
        "slug": "tlr7",
        "symbol": "TLR7",
        "hgnc": "HGNC:15631",
        "name": "toll like receptor 7",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tlr7"
      },
      {
        "slug": "tnfaip3",
        "symbol": "TNFAIP3",
        "hgnc": "HGNC:11896",
        "name": "TNF alpha induced protein 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfaip3"
      },
      {
        "slug": "tnfsf4",
        "symbol": "TNFSF4",
        "hgnc": "HGNC:11934",
        "name": "TNF superfamily member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfsf4"
      },
      {
        "slug": "tnip1",
        "symbol": "TNIP1",
        "hgnc": "HGNC:16903",
        "name": "TNFAIP3 interacting protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnip1"
      },
      {
        "slug": "ube2l3",
        "symbol": "UBE2L3",
        "hgnc": "HGNC:12488",
        "name": "ubiquitin conjugating enzyme E2 L3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube2l3"
      },
      {
        "slug": "acp5",
        "symbol": "ACP5",
        "hgnc": "HGNC:124",
        "name": "acid phosphatase 5, tartrate resistant",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/acp5"
      },
      {
        "slug": "adar",
        "symbol": "ADAR",
        "hgnc": "HGNC:225",
        "name": "adenosine deaminase RNA specific",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adar"
      },
      {
        "slug": "fcgr2a",
        "symbol": "FCGR2A",
        "hgnc": "HGNC:3616",
        "name": "Fc gamma receptor IIa",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcgr2a"
      },
      {
        "slug": "ifih1",
        "symbol": "IFIH1",
        "hgnc": "HGNC:18873",
        "name": "interferon induced with helicase C domain 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifih1"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "lsm11",
        "symbol": "LSM11",
        "hgnc": "HGNC:30860",
        "name": "LSM11, U7 small nuclear RNA associated",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lsm11"
      },
      {
        "slug": "notch3",
        "symbol": "NOTCH3",
        "hgnc": "HGNC:7883",
        "name": "notch receptor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch3"
      },
      {
        "slug": "rnaseh2a",
        "symbol": "RNASEH2A",
        "hgnc": "HGNC:18518",
        "name": "ribonuclease H2 subunit A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnaseh2a"
      },
      {
        "slug": "rnaseh2b",
        "symbol": "RNASEH2B",
        "hgnc": "HGNC:25671",
        "name": "ribonuclease H2 subunit B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnaseh2b"
      },
      {
        "slug": "rnaseh2c",
        "symbol": "RNASEH2C",
        "hgnc": "HGNC:24116",
        "name": "ribonuclease H2 subunit C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnaseh2c"
      },
      {
        "slug": "rnu7-1",
        "symbol": "RNU7-1",
        "hgnc": "HGNC:34033",
        "name": "RNA, U7 small nuclear 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu7-1"
      },
      {
        "slug": "samhd1",
        "symbol": "SAMHD1",
        "hgnc": "HGNC:15925",
        "name": "SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/samhd1"
      },
      {
        "slug": "sec61a1",
        "symbol": "SEC61A1",
        "hgnc": "HGNC:18276",
        "name": "SEC61 translocon subunit alpha 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec61a1"
      },
      {
        "slug": "zmpste24",
        "symbol": "ZMPSTE24",
        "hgnc": "HGNC:12877",
        "name": "zinc metallopeptidase STE24",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmpste24"
      },
      {
        "slug": "clcnkb",
        "symbol": "CLCNKB",
        "hgnc": "HGNC:2027",
        "name": "chloride voltage-gated channel Kb",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcnkb"
      },
      {
        "slug": "hras",
        "symbol": "HRAS",
        "hgnc": "HGNC:5173",
        "name": "HRas proto-oncogene, GTPase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hras"
      },
      {
        "slug": "sat1",
        "symbol": "SAT1",
        "hgnc": "HGNC:10540",
        "name": "spermidine/spermine N1-acetyltransferase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sat1"
      },
      {
        "slug": "slc12a3",
        "symbol": "SLC12A3",
        "hgnc": "HGNC:10912",
        "name": "solute carrier family 12 member 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a3"
      },
      {
        "slug": "agxt",
        "symbol": "AGXT",
        "hgnc": "HGNC:341",
        "name": "alanine--glyoxylate aminotransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/agxt"
      }
    ]
  }
}