{
  "url": "https://dantelabs.com/traits/primary-hypothyroidism",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "primary-hypothyroidism",
    "id": "HP:0000832",
    "name": "Primary hypothyroidism",
    "definition": "A type of hypothyroidism that results from a defect in the thyroid gland.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "hypothyroidism",
        "name": "Underactive thyroid",
        "url": "https://dantelabs.com/traits/hypothyroidism"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "rnu6atac",
        "symbol": "RNU6ATAC",
        "hgnc": "HGNC:34017",
        "name": "RNA, U6atac small nuclear",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu6atac"
      },
      {
        "slug": "ubr1",
        "symbol": "UBR1",
        "hgnc": "HGNC:16808",
        "name": "ubiquitin protein ligase E3 component n-recognin 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubr1"
      },
      {
        "slug": "stat1",
        "symbol": "STAT1",
        "hgnc": "HGNC:11362",
        "name": "signal transducer and activator of transcription 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat1"
      },
      {
        "slug": "alms1",
        "symbol": "ALMS1",
        "hgnc": "HGNC:428",
        "name": "ALMS1 centrosome and basal body associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alms1"
      },
      {
        "slug": "ctns",
        "symbol": "CTNS",
        "hgnc": "HGNC:2518",
        "name": "cystinosin, lysosomal cystine transporter",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctns"
      },
      {
        "slug": "ddost",
        "symbol": "DDOST",
        "hgnc": "HGNC:2728",
        "name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddost"
      }
    ]
  }
}