{
  "url": "https://dantelabs.com/traits/patchy-alopecia",
  "trait": {
    "bundleId": "2026.10.18-e609d43e",
    "release": "2026-09-01",
    "slug": "patchy-alopecia",
    "id": "HP:0002232",
    "name": "Patchy baldness",
    "label": "Patchy alopecia",
    "definition": "Transient, non-scarring hair loss and preservation of the hair follicle located in in well-defined patches.",
    "synonyms": [
      "Alopecia areata"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "acquired-abnormal-hair-pattern",
        "name": "Acquired abnormal hair pattern",
        "url": "https://dantelabs.com/traits/acquired-abnormal-hair-pattern"
      },
      {
        "slug": "alopecia",
        "name": "Hair loss",
        "url": "https://dantelabs.com/traits/alopecia"
      }
    ],
    "narrower": [
      {
        "slug": "atrophic-patchy-alopecia",
        "name": "Atrophic, patchy alopecia",
        "genes": 3,
        "url": "https://dantelabs.com/traits/atrophic-patchy-alopecia"
      }
    ],
    "genes": [
      {
        "slug": "col17a1",
        "symbol": "COL17A1",
        "hgnc": "HGNC:2194",
        "name": "collagen type XVII alpha 1 chain",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col17a1"
      },
      {
        "slug": "il2ra",
        "symbol": "IL2RA",
        "hgnc": "HGNC:6008",
        "name": "interleukin 2 receptor subunit alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il2ra"
      },
      {
        "slug": "lamb3",
        "symbol": "LAMB3",
        "hgnc": "HGNC:6490",
        "name": "laminin subunit beta 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb3"
      },
      {
        "slug": "tra2b",
        "symbol": "TRA2B",
        "hgnc": "HGNC:10781",
        "name": "transformer 2 beta homolog",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tra2b"
      },
      {
        "slug": "dsg4",
        "symbol": "DSG4",
        "hgnc": "HGNC:21307",
        "name": "desmoglein 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsg4"
      },
      {
        "slug": "ebp",
        "symbol": "EBP",
        "hgnc": "HGNC:3133",
        "name": "EBP cholestenol delta-isomerase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ebp"
      },
      {
        "slug": "hr",
        "symbol": "HR",
        "hgnc": "HGNC:5172",
        "name": "HR lysine demethylase and nuclear receptor corepressor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hr"
      },
      {
        "slug": "kdm5c",
        "symbol": "KDM5C",
        "hgnc": "HGNC:11114",
        "name": "lysine demethylase 5C",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kdm5c"
      },
      {
        "slug": "krt81",
        "symbol": "KRT81",
        "hgnc": "HGNC:6458",
        "name": "keratin 81",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt81"
      },
      {
        "slug": "krt83",
        "symbol": "KRT83",
        "hgnc": "HGNC:6460",
        "name": "keratin 83",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt83"
      },
      {
        "slug": "krt86",
        "symbol": "KRT86",
        "hgnc": "HGNC:6463",
        "name": "keratin 86",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt86"
      },
      {
        "slug": "exosc2",
        "symbol": "EXOSC2",
        "hgnc": "HGNC:17097",
        "name": "exosome component 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/exosc2"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "porcn",
        "symbol": "PORCN",
        "hgnc": "HGNC:17652",
        "name": "porcupine O-acyltransferase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/porcn"
      },
      {
        "slug": "trac",
        "symbol": "TRAC",
        "hgnc": "HGNC:12029",
        "name": "T cell receptor alpha constant",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trac"
      },
      {
        "slug": "zmpste24",
        "symbol": "ZMPSTE24",
        "hgnc": "HGNC:12877",
        "name": "zinc metallopeptidase STE24",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmpste24"
      },
      {
        "slug": "aire",
        "symbol": "AIRE",
        "hgnc": "HGNC:360",
        "name": "autoimmune regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aire"
      },
      {
        "slug": "asl",
        "symbol": "ASL",
        "hgnc": "HGNC:746",
        "name": "argininosuccinate lyase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asl"
      },
      {
        "slug": "blm",
        "symbol": "BLM",
        "hgnc": "HGNC:1058",
        "name": "BLM RecQ like helicase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blm"
      },
      {
        "slug": "kctd1",
        "symbol": "KCTD1",
        "hgnc": "HGNC:18249",
        "name": "potassium channel tetramerization domain containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kctd1"
      },
      {
        "slug": "padi3",
        "symbol": "PADI3",
        "hgnc": "HGNC:18337",
        "name": "peptidyl arginine deiminase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/padi3"
      },
      {
        "slug": "sel1l",
        "symbol": "SEL1L",
        "hgnc": "HGNC:10717",
        "name": "SEL1L adaptor subunit of SYVN1 ubiquitin ligase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sel1l"
      },
      {
        "slug": "tgm3",
        "symbol": "TGM3",
        "hgnc": "HGNC:11779",
        "name": "transglutaminase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgm3"
      },
      {
        "slug": "hras",
        "symbol": "HRAS",
        "hgnc": "HGNC:5173",
        "name": "HRas proto-oncogene, GTPase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hras"
      },
      {
        "slug": "adam17",
        "symbol": "ADAM17",
        "hgnc": "HGNC:195",
        "name": "ADAM metallopeptidase domain 17",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adam17"
      },
      {
        "slug": "ecm1",
        "symbol": "ECM1",
        "hgnc": "HGNC:3153",
        "name": "extracellular matrix protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ecm1"
      },
      {
        "slug": "nectin4",
        "symbol": "NECTIN4",
        "hgnc": "HGNC:19688",
        "name": "nectin cell adhesion molecule 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nectin4"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp63"
      }
    ]
  }
}