{
  "url": "https://dantelabs.com/traits/pain-insensitivity",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "pain-insensitivity",
    "id": "HP:0007021",
    "name": "Pain insensitivity",
    "definition": "Inability to perceive painful stimuli.",
    "synonyms": [
      "Absence of pain sensation"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "impaired-pain-sensation",
        "name": "Impaired pain sensation",
        "url": "https://dantelabs.com/traits/impaired-pain-sensation"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "atxn7l3",
        "symbol": "ATXN7L3",
        "hgnc": "HGNC:25416",
        "name": "ataxin 7 like 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn7l3"
      },
      {
        "slug": "cacna2d1",
        "symbol": "CACNA2D1",
        "hgnc": "HGNC:1399",
        "name": "calcium voltage-gated channel auxiliary subunit alpha2delta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna2d1"
      },
      {
        "slug": "dnm1l",
        "symbol": "DNM1L",
        "hgnc": "HGNC:2973",
        "name": "dynamin 1L",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnm1l"
      },
      {
        "slug": "dst",
        "symbol": "DST",
        "hgnc": "HGNC:1090",
        "name": "dystonin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dst"
      },
      {
        "slug": "flvcr1",
        "symbol": "FLVCR1",
        "hgnc": "HGNC:24682",
        "name": "FLVCR choline and heme transporter 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flvcr1"
      },
      {
        "slug": "iars2",
        "symbol": "IARS2",
        "hgnc": "HGNC:29685",
        "name": "isoleucyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iars2"
      },
      {
        "slug": "lrrc7",
        "symbol": "LRRC7",
        "hgnc": "HGNC:18531",
        "name": "leucine rich repeat containing 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrc7"
      },
      {
        "slug": "ngf",
        "symbol": "NGF",
        "hgnc": "HGNC:7808",
        "name": "nerve growth factor",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ngf"
      },
      {
        "slug": "ngly1",
        "symbol": "NGLY1",
        "hgnc": "HGNC:17646",
        "name": "N-glycanase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ngly1"
      },
      {
        "slug": "ntrk1",
        "symbol": "NTRK1",
        "hgnc": "HGNC:8031",
        "name": "neurotrophic receptor tyrosine kinase 1",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ntrk1"
      },
      {
        "slug": "prdm12",
        "symbol": "PRDM12",
        "hgnc": "HGNC:13997",
        "name": "PR/SET domain 12",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prdm12"
      },
      {
        "slug": "scn11a",
        "symbol": "SCN11A",
        "hgnc": "HGNC:10583",
        "name": "sodium voltage-gated channel alpha subunit 11",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn11a"
      },
      {
        "slug": "scn9a",
        "symbol": "SCN9A",
        "hgnc": "HGNC:10597",
        "name": "sodium voltage-gated channel alpha subunit 9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn9a"
      },
      {
        "slug": "tcp1",
        "symbol": "TCP1",
        "hgnc": "HGNC:11655",
        "name": "t-complex 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcp1"
      },
      {
        "slug": "unc13a",
        "symbol": "UNC13A",
        "hgnc": "HGNC:23150",
        "name": "unc-13 homolog A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc13a"
      },
      {
        "slug": "zfhx2",
        "symbol": "ZFHX2",
        "hgnc": "HGNC:20152",
        "name": "zinc finger homeobox 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfhx2"
      },
      {
        "slug": "atl1",
        "symbol": "ATL1",
        "hgnc": "HGNC:11231",
        "name": "atlastin GTPase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atl1"
      },
      {
        "slug": "atl3",
        "symbol": "ATL3",
        "hgnc": "HGNC:24526",
        "name": "atlastin GTPase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atl3"
      },
      {
        "slug": "cltcl1",
        "symbol": "CLTCL1",
        "hgnc": "HGNC:2093",
        "name": "clathrin heavy chain like 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cltcl1"
      },
      {
        "slug": "ddhd1",
        "symbol": "DDHD1",
        "hgnc": "HGNC:19714",
        "name": "DDHD domain containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddhd1"
      },
      {
        "slug": "deaf1",
        "symbol": "DEAF1",
        "hgnc": "HGNC:14677",
        "name": "DEAF1 transcription factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/deaf1"
      },
      {
        "slug": "ebf3",
        "symbol": "EBF3",
        "hgnc": "HGNC:19087",
        "name": "EBF transcription factor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ebf3"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "rai1",
        "symbol": "RAI1",
        "hgnc": "HGNC:9834",
        "name": "retinoic acid induced 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rai1"
      },
      {
        "slug": "sptlc1",
        "symbol": "SPTLC1",
        "hgnc": "HGNC:11277",
        "name": "serine palmitoyltransferase long chain base subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptlc1"
      },
      {
        "slug": "sptlc2",
        "symbol": "SPTLC2",
        "hgnc": "HGNC:11278",
        "name": "serine palmitoyltransferase long chain base subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptlc2"
      },
      {
        "slug": "tdp1",
        "symbol": "TDP1",
        "hgnc": "HGNC:18884",
        "name": "tyrosyl-DNA phosphodiesterase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tdp1"
      },
      {
        "slug": "trpm3",
        "symbol": "TRPM3",
        "hgnc": "HGNC:17992",
        "name": "transient receptor potential cation channel subfamily M member 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpm3"
      },
      {
        "slug": "gria3",
        "symbol": "GRIA3",
        "hgnc": "HGNC:4573",
        "name": "glutamate ionotropic receptor AMPA type subunit 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gria3"
      },
      {
        "slug": "kdm5c",
        "symbol": "KDM5C",
        "hgnc": "HGNC:11114",
        "name": "lysine demethylase 5C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm5c"
      },
      {
        "slug": "rfx7",
        "symbol": "RFX7",
        "hgnc": "HGNC:25777",
        "name": "regulatory factor X7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfx7"
      },
      {
        "slug": "snupn",
        "symbol": "SNUPN",
        "hgnc": "HGNC:14245",
        "name": "snurportin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snupn"
      },
      {
        "slug": "tmem218",
        "symbol": "TMEM218",
        "hgnc": "HGNC:27344",
        "name": "transmembrane protein 218",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem218"
      },
      {
        "slug": "trio",
        "symbol": "TRIO",
        "hgnc": "HGNC:12303",
        "name": "trio Rho guanine nucleotide exchange factor",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/trio"
      },
      {
        "slug": "hdac4",
        "symbol": "HDAC4",
        "hgnc": "HGNC:14063",
        "name": "histone deacetylase 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hdac4"
      },
      {
        "slug": "mpv17",
        "symbol": "MPV17",
        "hgnc": "HGNC:7224",
        "name": "mitochondrial inner membrane protein MPV17",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpv17"
      }
    ]
  }
}