{
  "url": "https://dantelabs.com/traits/nodular-goiter",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "nodular-goiter",
    "id": "HP:0005994",
    "name": "Nodular goiter",
    "definition": "Enlargement of the thyroid gland related to one or more nodules in the thyroid gland.",
    "synonyms": [
      "Nodular goitre"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "goiter",
        "name": "Enlarged thyroid gland in neck",
        "url": "https://dantelabs.com/traits/goiter"
      }
    ],
    "narrower": [
      {
        "slug": "multinodular-goiter",
        "name": "Multinodular goiter",
        "genes": 9,
        "url": "https://dantelabs.com/traits/multinodular-goiter"
      }
    ],
    "genes": [
      {
        "slug": "foxe1",
        "symbol": "FOXE1",
        "hgnc": "HGNC:3806",
        "name": "forkhead box E1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxe1"
      },
      {
        "slug": "habp2",
        "symbol": "HABP2",
        "hgnc": "HGNC:4798",
        "name": "hyaluronan binding protein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/habp2"
      },
      {
        "slug": "minpp1",
        "symbol": "MINPP1",
        "hgnc": "HGNC:7102",
        "name": "multiple inositol-polyphosphate phosphatase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/minpp1"
      },
      {
        "slug": "mmp14",
        "symbol": "MMP14",
        "hgnc": "HGNC:7160",
        "name": "matrix metallopeptidase 14",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp14"
      },
      {
        "slug": "mmp2",
        "symbol": "MMP2",
        "hgnc": "HGNC:7166",
        "name": "matrix metallopeptidase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp2"
      },
      {
        "slug": "ret",
        "symbol": "RET",
        "hgnc": "HGNC:9967",
        "name": "ret proto-oncogene",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ret"
      }
    ]
  }
}