{
  "url": "https://dantelabs.com/traits/narrow-philtrum",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "narrow-philtrum",
    "id": "HP:0011829",
    "name": "Narrow philtrum",
    "definition": "Distance between the philtral ridges, measured just above the vermilion border, more than 2 standard deviations below the mean. Alternatively, an apparently decreased distance between the ridges of the philtrum.",
    "synonyms": [
      "Decreased breadth of philtrum",
      "Decreased horizontal dimension of philtrum",
      "Decreased transverse dimension of philtrum",
      "Decreased width of philtrum",
      "Philtrum, Narrow",
      "Thin philtrum"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-philtrum",
        "name": "Abnormality of the philtrum",
        "url": "https://dantelabs.com/traits/abnormality-of-the-philtrum"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cilk1",
        "symbol": "CILK1",
        "hgnc": "HGNC:21219",
        "name": "ciliogenesis associated kinase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cilk1"
      },
      {
        "slug": "kdm6b",
        "symbol": "KDM6B",
        "hgnc": "HGNC:29012",
        "name": "lysine demethylase 6B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6b"
      },
      {
        "slug": "pdgfrb",
        "symbol": "PDGFRB",
        "hgnc": "HGNC:8804",
        "name": "platelet derived growth factor receptor beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdgfrb"
      },
      {
        "slug": "smg8",
        "symbol": "SMG8",
        "hgnc": "HGNC:25551",
        "name": "SMG8 nonsense mediated mRNA decay factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smg8"
      }
    ]
  }
}