{
  "url": "https://dantelabs.com/traits/mottled-pigmentation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "mottled-pigmentation",
    "id": "HP:0001070",
    "name": "Mottled skin coloring",
    "label": "Mottled pigmentation",
    "definition": "Patchy and irregular skin pigmentation.",
    "synonyms": [
      "Mottled skin colouring"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-skin-pigmentation",
        "name": "Abnormal skin pigmentation",
        "url": "https://dantelabs.com/traits/abnormal-skin-pigmentation"
      }
    ],
    "narrower": [
      {
        "slug": "mottled-pigmentation-of-the-trunk-and-proximal-extremities",
        "name": "Mottled pigmentation of the trunk and proximal extremities",
        "genes": 1,
        "url": "https://dantelabs.com/traits/mottled-pigmentation-of-the-trunk-and-proximal-extremities"
      }
    ],
    "genes": [
      {
        "slug": "ltv1",
        "symbol": "LTV1",
        "hgnc": "HGNC:21173",
        "name": "LTV1 ribosome biogenesis factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ltv1"
      },
      {
        "slug": "zmpste24",
        "symbol": "ZMPSTE24",
        "hgnc": "HGNC:12877",
        "name": "zinc metallopeptidase STE24",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmpste24"
      },
      {
        "slug": "hpgd",
        "symbol": "HPGD",
        "hgnc": "HGNC:5154",
        "name": "15-hydroxyprostaglandin dehydrogenase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hpgd"
      },
      {
        "slug": "krt14",
        "symbol": "KRT14",
        "hgnc": "HGNC:6416",
        "name": "keratin 14",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt14"
      },
      {
        "slug": "krt5",
        "symbol": "KRT5",
        "hgnc": "HGNC:6442",
        "name": "keratin 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt5"
      },
      {
        "slug": "duox2",
        "symbol": "DUOX2",
        "hgnc": "HGNC:13273",
        "name": "dual oxidase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/duox2"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "recql4",
        "symbol": "RECQL4",
        "hgnc": "HGNC:9949",
        "name": "RecQ like helicase 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/recql4"
      }
    ]
  }
}