{
  "url": "https://dantelabs.com/traits/increased-adipose-tissue",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "increased-adipose-tissue",
    "id": "HP:0009126",
    "name": "Increased adipose tissue",
    "definition": "An increase in adipose tissue mass by hyperplastic growth (increase in the number of adipocytes) or by hypertrophic growth (increase in the size of adipocytes occurring primarily by lipid accumulation within the cell).",
    "synonyms": [
      "Increased fat tissue"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-adipose-tissue-morphology",
        "name": "Abnormality of adipose tissue",
        "url": "https://dantelabs.com/traits/abnormal-adipose-tissue-morphology"
      },
      {
        "slug": "increased-connective-tissue",
        "name": "Increased connective tissue",
        "url": "https://dantelabs.com/traits/increased-connective-tissue"
      }
    ],
    "narrower": [
      {
        "slug": "increased-adipose-tissue-around-the-neck",
        "name": "Increased fat around the neck",
        "genes": 3,
        "url": "https://dantelabs.com/traits/increased-adipose-tissue-around-the-neck"
      },
      {
        "slug": "increased-intraabdominal-fat",
        "name": "Increased intraabdominal fat",
        "genes": 3,
        "url": "https://dantelabs.com/traits/increased-intraabdominal-fat"
      },
      {
        "slug": "increased-subcutaneous-truncal-adipose-tissue",
        "name": "Increased fat below the skin in trunk",
        "genes": 2,
        "url": "https://dantelabs.com/traits/increased-subcutaneous-truncal-adipose-tissue"
      },
      {
        "slug": "increased-intramuscular-fat",
        "name": "Increased intramuscular fat",
        "genes": 2,
        "url": "https://dantelabs.com/traits/increased-intramuscular-fat"
      }
    ],
    "genes": [
      {
        "slug": "mc4r",
        "symbol": "MC4R",
        "hgnc": "HGNC:6932",
        "name": "melanocortin 4 receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mc4r"
      },
      {
        "slug": "pcsk1",
        "symbol": "PCSK1",
        "hgnc": "HGNC:8743",
        "name": "proprotein convertase subtilisin/kexin type 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcsk1"
      },
      {
        "slug": "pomc",
        "symbol": "POMC",
        "hgnc": "HGNC:9201",
        "name": "proopiomelanocortin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pomc"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "mt-tk",
        "symbol": "MT-TK",
        "hgnc": "HGNC:7489",
        "name": "mitochondrially encoded tRNA-Lys (AAA/G)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tk"
      },
      {
        "slug": "inpp5k",
        "symbol": "INPP5K",
        "hgnc": "HGNC:33882",
        "name": "inositol polyphosphate-5-phosphatase K",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inpp5k"
      }
    ]
  }
}