{
  "url": "https://dantelabs.com/traits/imbalanced-hemoglobin-synthesis",
  "trait": {
    "bundleId": "2026.10.21-311f020e",
    "release": "2026-09-01",
    "slug": "imbalanced-hemoglobin-synthesis",
    "id": "HP:0005560",
    "name": "Imbalanced hemoglobin synthesis",
    "definition": "Normal hemoglobin synthesis is characterized by production of equal amounts of alpha and beta globins. This term refers to a deviation from this pattern and is the main characteristic of the various forms of thalassemia.",
    "synonyms": [
      "Imbalanced haemoglobin synthesis",
      "Imbalanced Hb synthesis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-hemoglobin",
        "name": "Abnormal hemoglobin",
        "url": "https://dantelabs.com/traits/abnormal-hemoglobin"
      }
    ],
    "narrower": [
      {
        "slug": "reduced-alpha-beta-synthesis-ratio",
        "name": "Reduced alpha/beta synthesis ratio",
        "genes": 4,
        "url": "https://dantelabs.com/traits/reduced-alpha-beta-synthesis-ratio"
      },
      {
        "slug": "reduced-beta-alpha-synthesis-ratio",
        "name": "Reduced beta/alpha synthesis ratio",
        "genes": 1,
        "url": "https://dantelabs.com/traits/reduced-beta-alpha-synthesis-ratio"
      }
    ],
    "genes": [
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hbb"
      }
    ]
  }
}