{
  "url": "https://dantelabs.com/traits/hemangioma",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hemangioma",
    "id": "HP:0001028",
    "name": "Strawberry mark",
    "label": "Hemangioma",
    "definition": "A hemangioma is a benign tumor characterized by blood-filled spaces lined by benign endothelial cells. A hemangioma characterized by large endothelial spaces (caverns) is called a cavernous hemangioma (in contrast to a hemangioma with small endothelial spaces, which is called capillary hemangioma).",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "vascular-neoplasm",
        "name": "Blood vessel tumor",
        "url": "https://dantelabs.com/traits/vascular-neoplasm"
      }
    ],
    "narrower": [
      {
        "slug": "capillary-hemangioma",
        "name": "Strawberry birthmark",
        "genes": 26,
        "url": "https://dantelabs.com/traits/capillary-hemangioma"
      },
      {
        "slug": "cavernous-hemangioma",
        "name": "Collection of dilated blood vessels that forms mass",
        "genes": 24,
        "url": "https://dantelabs.com/traits/cavernous-hemangioma"
      },
      {
        "slug": "arachnoid-hemangiomatosis",
        "name": "Arachnoid hemangiomatosis",
        "genes": 16,
        "url": "https://dantelabs.com/traits/arachnoid-hemangiomatosis"
      },
      {
        "slug": "retinal-capillary-hemangioma",
        "name": "Retinal capillary hemangioma",
        "genes": 16,
        "url": "https://dantelabs.com/traits/retinal-capillary-hemangioma"
      },
      {
        "slug": "facial-hemangioma",
        "name": "Facial hemangioma",
        "genes": 12,
        "url": "https://dantelabs.com/traits/facial-hemangioma"
      },
      {
        "slug": "choroidal-hemangioma",
        "name": "Choroidal hemangioma",
        "genes": 5,
        "url": "https://dantelabs.com/traits/choroidal-hemangioma"
      },
      {
        "slug": "glabellar-hemangioma",
        "name": "Glabellar hemangioma",
        "genes": 5,
        "url": "https://dantelabs.com/traits/glabellar-hemangioma"
      },
      {
        "slug": "lumbosacral-hemangioma",
        "name": "Lumbosacral hemangioma",
        "genes": 4,
        "url": "https://dantelabs.com/traits/lumbosacral-hemangioma"
      },
      {
        "slug": "hemangiomatosis",
        "name": "Hemangiomatosis",
        "genes": 3,
        "url": "https://dantelabs.com/traits/hemangiomatosis"
      },
      {
        "slug": "hemangioma-of-the-lip",
        "name": "Hemangioma of the lip",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hemangioma-of-the-lip"
      },
      {
        "slug": "visceral-hemangioma",
        "name": "Visceral hemangioma",
        "genes": 0,
        "url": "https://dantelabs.com/traits/visceral-hemangioma"
      }
    ],
    "genes": [
      {
        "slug": "cilk1",
        "symbol": "CILK1",
        "hgnc": "HGNC:21219",
        "name": "ciliogenesis associated kinase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cilk1"
      },
      {
        "slug": "fbxo28",
        "symbol": "FBXO28",
        "hgnc": "HGNC:29046",
        "name": "F-box protein 28",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo28"
      },
      {
        "slug": "ppp2r5c",
        "symbol": "PPP2R5C",
        "hgnc": "HGNC:9311",
        "name": "protein phosphatase 2 regulatory subunit B'gamma",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp2r5c"
      },
      {
        "slug": "spout1",
        "symbol": "SPOUT1",
        "hgnc": "HGNC:26933",
        "name": "SPOUT domain containing methyltransferase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spout1"
      },
      {
        "slug": "aggf1",
        "symbol": "AGGF1",
        "hgnc": "HGNC:24684",
        "name": "angiogenic factor with G-patch and FHA domains 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aggf1"
      },
      {
        "slug": "idh1",
        "symbol": "IDH1",
        "hgnc": "HGNC:5382",
        "name": "isocitrate dehydrogenase (NADP(+)) 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/idh1"
      },
      {
        "slug": "idh2",
        "symbol": "IDH2",
        "hgnc": "HGNC:5383",
        "name": "isocitrate dehydrogenase (NADP(+)) 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/idh2"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "pth1r",
        "symbol": "PTH1R",
        "hgnc": "HGNC:9608",
        "name": "parathyroid hormone 1 receptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pth1r"
      },
      {
        "slug": "tfap2a",
        "symbol": "TFAP2A",
        "hgnc": "HGNC:11742",
        "name": "transcription factor AP-2 alpha",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tfap2a"
      },
      {
        "slug": "thsd1",
        "symbol": "THSD1",
        "hgnc": "HGNC:17754",
        "name": "thrombospondin type 1 domain containing 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/thsd1"
      },
      {
        "slug": "bmpr1a",
        "symbol": "BMPR1A",
        "hgnc": "HGNC:1076",
        "name": "bone morphogenetic protein receptor type 1A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmpr1a"
      },
      {
        "slug": "ccm2",
        "symbol": "CCM2",
        "hgnc": "HGNC:21708",
        "name": "CCM2 scaffold protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccm2"
      },
      {
        "slug": "cplx1",
        "symbol": "CPLX1",
        "hgnc": "HGNC:2309",
        "name": "complexin 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cplx1"
      },
      {
        "slug": "ctbp1",
        "symbol": "CTBP1",
        "hgnc": "HGNC:2494",
        "name": "C-terminal binding protein 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ctbp1"
      },
      {
        "slug": "cyp26c1",
        "symbol": "CYP26C1",
        "hgnc": "HGNC:20577",
        "name": "cytochrome P450 family 26 subfamily C member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp26c1"
      },
      {
        "slug": "fgfrl1",
        "symbol": "FGFRL1",
        "hgnc": "HGNC:3693",
        "name": "fibroblast growth factor receptor like 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfrl1"
      },
      {
        "slug": "krit1",
        "symbol": "KRIT1",
        "hgnc": "HGNC:1573",
        "name": "KRIT1 ankyrin repeat containing",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krit1"
      },
      {
        "slug": "letm1",
        "symbol": "LETM1",
        "hgnc": "HGNC:6556",
        "name": "leucine zipper and EF-hand containing transmembrane protein 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/letm1"
      },
      {
        "slug": "nelfa",
        "symbol": "NELFA",
        "hgnc": "HGNC:12768",
        "name": "negative elongation factor complex member A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nelfa"
      },
      {
        "slug": "nsd2",
        "symbol": "NSD2",
        "hgnc": "HGNC:12766",
        "name": "nuclear receptor binding SET domain protein 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nsd2"
      },
      {
        "slug": "pdcd10",
        "symbol": "PDCD10",
        "hgnc": "HGNC:8761",
        "name": "programmed cell death 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdcd10"
      },
      {
        "slug": "pigg",
        "symbol": "PIGG",
        "hgnc": "HGNC:25985",
        "name": "phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigg"
      },
      {
        "slug": "shoc2",
        "symbol": "SHOC2",
        "hgnc": "HGNC:15454",
        "name": "SHOC2 leucine rich repeat scaffold protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/shoc2"
      },
      {
        "slug": "antxr1",
        "symbol": "ANTXR1",
        "hgnc": "HGNC:21014",
        "name": "ANTXR cell adhesion molecule 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/antxr1"
      },
      {
        "slug": "arid1b",
        "symbol": "ARID1B",
        "hgnc": "HGNC:18040",
        "name": "AT-rich interaction domain 1B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arid1b"
      },
      {
        "slug": "cdon",
        "symbol": "CDON",
        "hgnc": "HGNC:17104",
        "name": "cell adhesion associated, oncogene regulated",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdon"
      },
      {
        "slug": "clpb",
        "symbol": "CLPB",
        "hgnc": "HGNC:30664",
        "name": "ClpB family mitochondrial disaggregase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clpb"
      },
      {
        "slug": "creld1",
        "symbol": "CRELD1",
        "hgnc": "HGNC:14630",
        "name": "CRELD disulfide isomerase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/creld1"
      },
      {
        "slug": "cripto",
        "symbol": "CRIPTO",
        "hgnc": "HGNC:11701",
        "name": "cripto, EGF-CFC family member",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cripto"
      },
      {
        "slug": "disp1",
        "symbol": "DISP1",
        "hgnc": "HGNC:19711",
        "name": "dispatched RND transporter family member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/disp1"
      },
      {
        "slug": "dll1",
        "symbol": "DLL1",
        "hgnc": "HGNC:2908",
        "name": "delta like canonical Notch ligand 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dll1"
      },
      {
        "slug": "elane",
        "symbol": "ELANE",
        "hgnc": "HGNC:3309",
        "name": "elastase, neutrophil expressed",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elane"
      },
      {
        "slug": "fbxo22",
        "symbol": "FBXO22",
        "hgnc": "HGNC:13593",
        "name": "F-box protein 22",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo22"
      },
      {
        "slug": "fgf8",
        "symbol": "FGF8",
        "hgnc": "HGNC:3686",
        "name": "fibroblast growth factor 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf8"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "foxh1",
        "symbol": "FOXH1",
        "hgnc": "HGNC:3814",
        "name": "forkhead box H1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxh1"
      },
      {
        "slug": "gas1",
        "symbol": "GAS1",
        "hgnc": "HGNC:4165",
        "name": "growth arrest specific 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gas1"
      },
      {
        "slug": "gfi1",
        "symbol": "GFI1",
        "hgnc": "HGNC:4237",
        "name": "growth factor independent 1 transcriptional repressor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfi1"
      },
      {
        "slug": "gli2",
        "symbol": "GLI2",
        "hgnc": "HGNC:4318",
        "name": "GLI family zinc finger 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gli2"
      },
      {
        "slug": "h4c5",
        "symbol": "H4C5",
        "hgnc": "HGNC:4790",
        "name": "H4 clustered histone 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h4c5"
      },
      {
        "slug": "kdm6b",
        "symbol": "KDM6B",
        "hgnc": "HGNC:29012",
        "name": "lysine demethylase 6B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6b"
      },
      {
        "slug": "map2k2",
        "symbol": "MAP2K2",
        "hgnc": "HGNC:6842",
        "name": "mitogen-activated protein kinase kinase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map2k2"
      },
      {
        "slug": "msl3",
        "symbol": "MSL3",
        "hgnc": "HGNC:7370",
        "name": "MSL complex subunit 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msl3"
      },
      {
        "slug": "mtor",
        "symbol": "MTOR",
        "hgnc": "HGNC:3942",
        "name": "mechanistic target of rapamycin kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtor"
      },
      {
        "slug": "nodal",
        "symbol": "NODAL",
        "hgnc": "HGNC:7865",
        "name": "nodal growth differentiation factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nodal"
      },
      {
        "slug": "ptch1",
        "symbol": "PTCH1",
        "hgnc": "HGNC:9585",
        "name": "patched 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptch1"
      },
      {
        "slug": "shh",
        "symbol": "SHH",
        "hgnc": "HGNC:10848",
        "name": "sonic hedgehog signaling molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/shh"
      },
      {
        "slug": "six3",
        "symbol": "SIX3",
        "hgnc": "HGNC:10889",
        "name": "SIX homeobox 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/six3"
      },
      {
        "slug": "spen",
        "symbol": "SPEN",
        "hgnc": "HGNC:17575",
        "name": "spen family transcriptional repressor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spen"
      },
      {
        "slug": "srp19",
        "symbol": "SRP19",
        "hgnc": "HGNC:11300",
        "name": "signal recognition particle 19",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srp19"
      },
      {
        "slug": "sufu",
        "symbol": "SUFU",
        "hgnc": "HGNC:16466",
        "name": "SUFU negative regulator of hedgehog signaling",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sufu"
      },
      {
        "slug": "tcirg1",
        "symbol": "TCIRG1",
        "hgnc": "HGNC:11647",
        "name": "T cell immune regulator 1, ATPase H+ transporting V0 subunit a3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcirg1"
      },
      {
        "slug": "tgif1",
        "symbol": "TGIF1",
        "hgnc": "HGNC:11776",
        "name": "TGFB induced factor homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgif1"
      },
      {
        "slug": "zic2",
        "symbol": "ZIC2",
        "hgnc": "HGNC:12873",
        "name": "Zic family zinc finger 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zic2"
      },
      {
        "slug": "apc2",
        "symbol": "APC2",
        "hgnc": "HGNC:24036",
        "name": "APC regulator of Wnt signaling pathway 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apc2"
      },
      {
        "slug": "calr",
        "symbol": "CALR",
        "hgnc": "HGNC:1455",
        "name": "calreticulin",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calr"
      },
      {
        "slug": "hras",
        "symbol": "HRAS",
        "hgnc": "HGNC:5173",
        "name": "HRas proto-oncogene, GTPase",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hras"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jak2"
      },
      {
        "slug": "mpl",
        "symbol": "MPL",
        "hgnc": "HGNC:7217",
        "name": "MPL proto-oncogene, thrombopoietin receptor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpl"
      },
      {
        "slug": "nf1",
        "symbol": "NF1",
        "hgnc": "HGNC:7765",
        "name": "neurofibromin 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf1"
      },
      {
        "slug": "nsd1",
        "symbol": "NSD1",
        "hgnc": "HGNC:14234",
        "name": "nuclear receptor binding SET domain protein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsd1"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "akt1",
        "symbol": "AKT1",
        "hgnc": "HGNC:391",
        "name": "AKT serine/threonine kinase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt1"
      },
      {
        "slug": "ctsa",
        "symbol": "CTSA",
        "hgnc": "HGNC:9251",
        "name": "cathepsin A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctsa"
      },
      {
        "slug": "dpm1",
        "symbol": "DPM1",
        "hgnc": "HGNC:3005",
        "name": "dolichyl-phosphate mannosyltransferase subunit 1, catalytic",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpm1"
      },
      {
        "slug": "flt4",
        "symbol": "FLT4",
        "hgnc": "HGNC:3767",
        "name": "fms related receptor tyrosine kinase 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flt4"
      },
      {
        "slug": "gpc6",
        "symbol": "GPC6",
        "hgnc": "HGNC:4454",
        "name": "glypican 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpc6"
      },
      {
        "slug": "kif1b",
        "symbol": "KIF1B",
        "hgnc": "HGNC:16636",
        "name": "kinesin family member 1B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif1b"
      },
      {
        "slug": "kras",
        "symbol": "KRAS",
        "hgnc": "HGNC:6407",
        "name": "KRas proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kras"
      },
      {
        "slug": "max",
        "symbol": "MAX",
        "hgnc": "HGNC:6913",
        "name": "MYC associated transcriptional regulator X",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/max"
      },
      {
        "slug": "nras",
        "symbol": "NRAS",
        "hgnc": "HGNC:7989",
        "name": "NRAS proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nras"
      },
      {
        "slug": "ret",
        "symbol": "RET",
        "hgnc": "HGNC:9967",
        "name": "ret proto-oncogene",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ret"
      },
      {
        "slug": "sec23b",
        "symbol": "SEC23B",
        "hgnc": "HGNC:10702",
        "name": "SEC23 homolog B, COPII component",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec23b"
      },
      {
        "slug": "tmem127",
        "symbol": "TMEM127",
        "hgnc": "HGNC:26038",
        "name": "transmembrane protein 127",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem127"
      },
      {
        "slug": "vhl",
        "symbol": "VHL",
        "hgnc": "HGNC:12687",
        "name": "von Hippel-Lindau tumor suppressor",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vhl"
      }
    ]
  }
}