{
  "url": "https://dantelabs.com/traits/heart-murmur",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "heart-murmur",
    "id": "HP:0030148",
    "name": "Heart murmur",
    "definition": "An extra or unusual sound heard during a heartbeat caused vibrations resulting from the flow of blood through the heart.",
    "synonyms": [
      "Heart murmurs",
      "Cardiac murmur",
      "Cardiac murmurs"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-heart-sound",
        "name": "Abnormal heart sound",
        "url": "https://dantelabs.com/traits/abnormal-heart-sound"
      }
    ],
    "narrower": [
      {
        "slug": "systolic-heart-murmur",
        "name": "Systolic heart murmur",
        "genes": 16,
        "url": "https://dantelabs.com/traits/systolic-heart-murmur"
      }
    ],
    "genes": [
      {
        "slug": "rnu6atac",
        "symbol": "RNU6ATAC",
        "hgnc": "HGNC:34017",
        "name": "RNA, U6atac small nuclear",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu6atac"
      },
      {
        "slug": "sco2",
        "symbol": "SCO2",
        "hgnc": "HGNC:10604",
        "name": "synthesis of cytochrome C oxidase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sco2"
      },
      {
        "slug": "slc25a4",
        "symbol": "SLC25A4",
        "hgnc": "HGNC:10990",
        "name": "solute carrier family 25 member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a4"
      },
      {
        "slug": "fbn1",
        "symbol": "FBN1",
        "hgnc": "HGNC:3603",
        "name": "fibrillin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbn1"
      },
      {
        "slug": "gata5",
        "symbol": "GATA5",
        "hgnc": "HGNC:15802",
        "name": "GATA binding protein 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata5"
      },
      {
        "slug": "nkx2-5",
        "symbol": "NKX2-5",
        "hgnc": "HGNC:2488",
        "name": "NK2 homeobox 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-5"
      },
      {
        "slug": "notch1",
        "symbol": "NOTCH1",
        "hgnc": "HGNC:7881",
        "name": "notch receptor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch1"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      },
      {
        "slug": "robo4",
        "symbol": "ROBO4",
        "hgnc": "HGNC:17985",
        "name": "roundabout guidance receptor 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/robo4"
      },
      {
        "slug": "smad6",
        "symbol": "SMAD6",
        "hgnc": "HGNC:6772",
        "name": "SMAD family member 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smad6"
      },
      {
        "slug": "abcg5",
        "symbol": "ABCG5",
        "hgnc": "HGNC:13886",
        "name": "ATP binding cassette subfamily G member 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcg5"
      },
      {
        "slug": "abcg8",
        "symbol": "ABCG8",
        "hgnc": "HGNC:13887",
        "name": "ATP binding cassette subfamily G member 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcg8"
      },
      {
        "slug": "apob",
        "symbol": "APOB",
        "hgnc": "HGNC:603",
        "name": "apolipoprotein B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apob"
      },
      {
        "slug": "fig4",
        "symbol": "FIG4",
        "hgnc": "HGNC:16873",
        "name": "FIG4 phosphoinositide 5-phosphatase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fig4"
      },
      {
        "slug": "gaa",
        "symbol": "GAA",
        "hgnc": "HGNC:4065",
        "name": "alpha glucosidase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gaa"
      },
      {
        "slug": "ldlr",
        "symbol": "LDLR",
        "hgnc": "HGNC:6547",
        "name": "low density lipoprotein receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldlr"
      },
      {
        "slug": "ldlrap1",
        "symbol": "LDLRAP1",
        "hgnc": "HGNC:18640",
        "name": "low density lipoprotein receptor adaptor protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldlrap1"
      },
      {
        "slug": "nipbl",
        "symbol": "NIPBL",
        "hgnc": "HGNC:28862",
        "name": "NIPBL cohesin loading factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nipbl"
      },
      {
        "slug": "pcsk9",
        "symbol": "PCSK9",
        "hgnc": "HGNC:20001",
        "name": "proprotein convertase subtilisin/kexin type 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcsk9"
      },
      {
        "slug": "adamts19",
        "symbol": "ADAMTS19",
        "hgnc": "HGNC:17111",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 19",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts19"
      },
      {
        "slug": "adnp",
        "symbol": "ADNP",
        "hgnc": "HGNC:15766",
        "name": "activity dependent neuroprotector homeobox",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adnp"
      },
      {
        "slug": "bicra",
        "symbol": "BICRA",
        "hgnc": "HGNC:4332",
        "name": "BRD4 interacting chromatin remodeling complex associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bicra"
      },
      {
        "slug": "cic",
        "symbol": "CIC",
        "hgnc": "HGNC:14214",
        "name": "capicua transcriptional repressor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cic"
      },
      {
        "slug": "cwc27",
        "symbol": "CWC27",
        "hgnc": "HGNC:10664",
        "name": "CWC27 spliceosome associated cyclophilin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cwc27"
      },
      {
        "slug": "ddx6",
        "symbol": "DDX6",
        "hgnc": "HGNC:2747",
        "name": "DEAD-box helicase 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddx6"
      },
      {
        "slug": "lrrc7",
        "symbol": "LRRC7",
        "hgnc": "HGNC:18531",
        "name": "leucine rich repeat containing 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrc7"
      },
      {
        "slug": "pex2",
        "symbol": "PEX2",
        "hgnc": "HGNC:9717",
        "name": "peroxisomal biogenesis factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex2"
      },
      {
        "slug": "psmd12",
        "symbol": "PSMD12",
        "hgnc": "HGNC:9557",
        "name": "proteasome 26S subunit, non-ATPase 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmd12"
      },
      {
        "slug": "sdhd",
        "symbol": "SDHD",
        "hgnc": "HGNC:10683",
        "name": "succinate dehydrogenase complex subunit D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhd"
      },
      {
        "slug": "sptbn1",
        "symbol": "SPTBN1",
        "hgnc": "HGNC:11275",
        "name": "spectrin beta, non-erythrocytic 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptbn1"
      },
      {
        "slug": "gnptab",
        "symbol": "GNPTAB",
        "hgnc": "HGNC:29670",
        "name": "N-acetylglucosamine-1-phosphate transferase subunits alpha and beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnptab"
      },
      {
        "slug": "rbbp8",
        "symbol": "RBBP8",
        "hgnc": "HGNC:9891",
        "name": "RB binding protein 8, endonuclease",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbbp8"
      }
    ]
  }
}