{
  "url": "https://dantelabs.com/traits/follicular-hyperplasia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "follicular-hyperplasia",
    "id": "HP:0002729",
    "name": "Follicular hyperplasia",
    "definition": "Lymphadenopathy (enlargement of lymph nodes) owing to hyperplasia of follicular (germinal) centers.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "lymphadenopathy",
        "name": "Swollen lymph nodes",
        "url": "https://dantelabs.com/traits/lymphadenopathy"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ctnnbl1",
        "symbol": "CTNNBL1",
        "hgnc": "HGNC:15879",
        "name": "catenin beta like 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctnnbl1"
      },
      {
        "slug": "ikzf2",
        "symbol": "IKZF2",
        "hgnc": "HGNC:13177",
        "name": "IKAROS family zinc finger 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikzf2"
      },
      {
        "slug": "prkcd",
        "symbol": "PRKCD",
        "hgnc": "HGNC:9399",
        "name": "protein kinase C delta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkcd"
      },
      {
        "slug": "ptcra",
        "symbol": "PTCRA",
        "hgnc": "HGNC:21290",
        "name": "pre T cell antigen receptor alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptcra"
      },
      {
        "slug": "sting1",
        "symbol": "STING1",
        "hgnc": "HGNC:27962",
        "name": "stimulator of interferon response cGAMP interactor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sting1"
      },
      {
        "slug": "syk",
        "symbol": "SYK",
        "hgnc": "HGNC:11491",
        "name": "spleen associated tyrosine kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syk"
      },
      {
        "slug": "casp10",
        "symbol": "CASP10",
        "hgnc": "HGNC:1500",
        "name": "caspase 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casp10"
      },
      {
        "slug": "cd19",
        "symbol": "CD19",
        "hgnc": "HGNC:1633",
        "name": "CD19 molecule",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd19"
      },
      {
        "slug": "cr2",
        "symbol": "CR2",
        "hgnc": "HGNC:2336",
        "name": "complement C3d receptor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cr2"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "hgnc": "HGNC:11920",
        "name": "Fas cell surface death receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fas"
      },
      {
        "slug": "faslg",
        "symbol": "FASLG",
        "hgnc": "HGNC:11936",
        "name": "Fas ligand",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faslg"
      },
      {
        "slug": "icos",
        "symbol": "ICOS",
        "hgnc": "HGNC:5351",
        "name": "inducible T cell costimulator",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/icos"
      },
      {
        "slug": "nras",
        "symbol": "NRAS",
        "hgnc": "HGNC:7989",
        "name": "NRAS proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nras"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "tnfrsf13b",
        "symbol": "TNFRSF13B",
        "hgnc": "HGNC:18153",
        "name": "TNF receptor superfamily member 13B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf13b"
      },
      {
        "slug": "tnfrsf13c",
        "symbol": "TNFRSF13C",
        "hgnc": "HGNC:17755",
        "name": "TNF receptor superfamily member 13C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf13c"
      }
    ]
  }
}