{
  "url": "https://dantelabs.com/traits/foamy-urine",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "foamy-urine",
    "id": "HP:0031504",
    "name": "Foamy urine",
    "definition": "Urine has an increased amount of frothy fine bubbles.",
    "synonyms": [
      "Frothy urine"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-macroscopic-urine-appearance",
        "name": "Abnormal macroscopic urine appearance",
        "url": "https://dantelabs.com/traits/abnormal-macroscopic-urine-appearance"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "actn4",
        "symbol": "ACTN4",
        "hgnc": "HGNC:166",
        "name": "actinin alpha 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actn4"
      },
      {
        "slug": "ankfy1",
        "symbol": "ANKFY1",
        "hgnc": "HGNC:20763",
        "name": "ankyrin repeat and FYVE domain containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankfy1"
      },
      {
        "slug": "anln",
        "symbol": "ANLN",
        "hgnc": "HGNC:14082",
        "name": "anillin, actin binding protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/anln"
      },
      {
        "slug": "apol1",
        "symbol": "APOL1",
        "hgnc": "HGNC:618",
        "name": "apolipoprotein L1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apol1"
      },
      {
        "slug": "arhgap24",
        "symbol": "ARHGAP24",
        "hgnc": "HGNC:25361",
        "name": "Rho GTPase activating protein 24",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgap24"
      },
      {
        "slug": "arhgdia",
        "symbol": "ARHGDIA",
        "hgnc": "HGNC:678",
        "name": "Rho GDP dissociation inhibitor alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgdia"
      },
      {
        "slug": "avil",
        "symbol": "AVIL",
        "hgnc": "HGNC:14188",
        "name": "advillin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/avil"
      },
      {
        "slug": "cd2ap",
        "symbol": "CD2AP",
        "hgnc": "HGNC:14258",
        "name": "CD2 associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd2ap"
      },
      {
        "slug": "col4a3",
        "symbol": "COL4A3",
        "hgnc": "HGNC:2204",
        "name": "collagen type IV alpha 3 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a3"
      },
      {
        "slug": "coq8b",
        "symbol": "COQ8B",
        "hgnc": "HGNC:19041",
        "name": "coenzyme Q8B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq8b"
      },
      {
        "slug": "crb2",
        "symbol": "CRB2",
        "hgnc": "HGNC:18688",
        "name": "crumbs cell polarity complex component 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crb2"
      },
      {
        "slug": "daam2",
        "symbol": "DAAM2",
        "hgnc": "HGNC:18143",
        "name": "dishevelled associated activator of morphogenesis 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/daam2"
      },
      {
        "slug": "emp2",
        "symbol": "EMP2",
        "hgnc": "HGNC:3334",
        "name": "epithelial membrane protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emp2"
      },
      {
        "slug": "gapvd1",
        "symbol": "GAPVD1",
        "hgnc": "HGNC:23375",
        "name": "GTPase activating protein and VPS9 domains 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gapvd1"
      },
      {
        "slug": "inf2",
        "symbol": "INF2",
        "hgnc": "HGNC:23791",
        "name": "inverted formin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inf2"
      },
      {
        "slug": "kank2",
        "symbol": "KANK2",
        "hgnc": "HGNC:29300",
        "name": "KN motif and ankyrin repeat domains 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kank2"
      },
      {
        "slug": "lama5",
        "symbol": "LAMA5",
        "hgnc": "HGNC:6485",
        "name": "laminin subunit alpha 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lama5"
      },
      {
        "slug": "magi2",
        "symbol": "MAGI2",
        "hgnc": "HGNC:18957",
        "name": "membrane associated guanylate kinase, WW and PDZ domain containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/magi2"
      },
      {
        "slug": "myo1e",
        "symbol": "MYO1E",
        "hgnc": "HGNC:7599",
        "name": "myosin IE",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myo1e"
      },
      {
        "slug": "nphs1",
        "symbol": "NPHS1",
        "hgnc": "HGNC:7908",
        "name": "NPHS1 adhesion molecule, nephrin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nphs1"
      },
      {
        "slug": "nphs2",
        "symbol": "NPHS2",
        "hgnc": "HGNC:13394",
        "name": "NPHS2 stomatin family member, podocin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nphs2"
      },
      {
        "slug": "nup107",
        "symbol": "NUP107",
        "hgnc": "HGNC:29914",
        "name": "nucleoporin 107",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup107"
      },
      {
        "slug": "nup133",
        "symbol": "NUP133",
        "hgnc": "HGNC:18016",
        "name": "nucleoporin 133",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup133"
      },
      {
        "slug": "nup160",
        "symbol": "NUP160",
        "hgnc": "HGNC:18017",
        "name": "nucleoporin 160",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup160"
      },
      {
        "slug": "nup205",
        "symbol": "NUP205",
        "hgnc": "HGNC:18658",
        "name": "nucleoporin 205",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup205"
      },
      {
        "slug": "nup37",
        "symbol": "NUP37",
        "hgnc": "HGNC:29929",
        "name": "nucleoporin 37",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup37"
      },
      {
        "slug": "nup85",
        "symbol": "NUP85",
        "hgnc": "HGNC:8734",
        "name": "nucleoporin 85",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup85"
      },
      {
        "slug": "nup93",
        "symbol": "NUP93",
        "hgnc": "HGNC:28958",
        "name": "nucleoporin 93",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup93"
      },
      {
        "slug": "pax2",
        "symbol": "PAX2",
        "hgnc": "HGNC:8616",
        "name": "paired box 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax2"
      },
      {
        "slug": "plce1",
        "symbol": "PLCE1",
        "hgnc": "HGNC:17175",
        "name": "phospholipase C epsilon 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plce1"
      },
      {
        "slug": "ptpro",
        "symbol": "PTPRO",
        "hgnc": "HGNC:9678",
        "name": "protein tyrosine phosphatase receptor type O",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpro"
      },
      {
        "slug": "tbc1d8b",
        "symbol": "TBC1D8B",
        "hgnc": "HGNC:24715",
        "name": "TBC1 domain family member 8B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d8b"
      },
      {
        "slug": "trpc6",
        "symbol": "TRPC6",
        "hgnc": "HGNC:12338",
        "name": "transient receptor potential cation channel subfamily C member 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpc6"
      },
      {
        "slug": "wt1",
        "symbol": "WT1",
        "hgnc": "HGNC:12796",
        "name": "WT1 transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wt1"
      }
    ]
  }
}