{
  "url": "https://dantelabs.com/traits/colorectal-polyposis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "colorectal-polyposis",
    "id": "HP:0200063",
    "name": "Colorectal polyposis",
    "definition": "Multiple abnormal growths that arise from the lining of the large intestine (colon or rectum) and protrude into the intestinal lumen.",
    "synonyms": [
      "Colorectal polyps"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "large-intestinal-polyposis",
        "name": "Large intestinal polyposis",
        "url": "https://dantelabs.com/traits/large-intestinal-polyposis"
      },
      {
        "slug": "neoplasm-of-the-rectum",
        "name": "Rectal tumor",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-rectum"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "apc",
        "symbol": "APC",
        "hgnc": "HGNC:583",
        "name": "APC regulator of Wnt signaling pathway",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/apc"
      },
      {
        "slug": "msh3",
        "symbol": "MSH3",
        "hgnc": "HGNC:7326",
        "name": "mutS homolog 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msh3"
      },
      {
        "slug": "mutyh",
        "symbol": "MUTYH",
        "hgnc": "HGNC:7527",
        "name": "mutY DNA glycosylase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mutyh"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "rnf43",
        "symbol": "RNF43",
        "hgnc": "HGNC:18505",
        "name": "ring finger protein 43",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf43"
      },
      {
        "slug": "alk",
        "symbol": "ALK",
        "hgnc": "HGNC:427",
        "name": "ALK receptor tyrosine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alk"
      },
      {
        "slug": "axin2",
        "symbol": "AXIN2",
        "hgnc": "HGNC:904",
        "name": "axin 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/axin2"
      },
      {
        "slug": "bmpr1a",
        "symbol": "BMPR1A",
        "hgnc": "HGNC:1076",
        "name": "bone morphogenetic protein receptor type 1A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmpr1a"
      },
      {
        "slug": "dicer1",
        "symbol": "DICER1",
        "hgnc": "HGNC:17098",
        "name": "dicer 1, ribonuclease III",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dicer1"
      },
      {
        "slug": "grem1",
        "symbol": "GREM1",
        "hgnc": "HGNC:2001",
        "name": "gremlin 1, DAN family BMP antagonist",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grem1"
      },
      {
        "slug": "keap1",
        "symbol": "KEAP1",
        "hgnc": "HGNC:23177",
        "name": "kelch like ECH associated protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/keap1"
      },
      {
        "slug": "pold1",
        "symbol": "POLD1",
        "hgnc": "HGNC:9175",
        "name": "DNA polymerase delta 1, catalytic subunit",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pold1"
      },
      {
        "slug": "pole",
        "symbol": "POLE",
        "hgnc": "HGNC:9177",
        "name": "DNA polymerase epsilon, catalytic subunit",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pole"
      },
      {
        "slug": "cdkn2a",
        "symbol": "CDKN2A",
        "hgnc": "HGNC:1787",
        "name": "cyclin dependent kinase inhibitor 2A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn2a"
      },
      {
        "slug": "chek2",
        "symbol": "CHEK2",
        "hgnc": "HGNC:16627",
        "name": "checkpoint kinase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chek2"
      },
      {
        "slug": "mdm2",
        "symbol": "MDM2",
        "hgnc": "HGNC:6973",
        "name": "MDM2 proto-oncogene",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mdm2"
      },
      {
        "slug": "tp53",
        "symbol": "TP53",
        "hgnc": "HGNC:11998",
        "name": "tumor protein p53",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp53"
      }
    ]
  }
}