{
  "url": "https://dantelabs.com/traits/cleft-soft-palate",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "cleft-soft-palate",
    "id": "HP:0000185",
    "name": "Cleft soft palate",
    "definition": "Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency.",
    "synonyms": [
      "Cleft muscular palate",
      "Cleft of soft palate",
      "Cleft velum"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-soft-palate-morphology",
        "name": "Abnormal soft palate morphology",
        "url": "https://dantelabs.com/traits/abnormal-soft-palate-morphology"
      },
      {
        "slug": "cleft-palate",
        "name": "Cleft palate",
        "url": "https://dantelabs.com/traits/cleft-palate"
      }
    ],
    "narrower": [
      {
        "slug": "submucous-cleft-soft-palate",
        "name": "Submucous cleft soft palate",
        "genes": 12,
        "url": "https://dantelabs.com/traits/submucous-cleft-soft-palate"
      },
      {
        "slug": "submucous-cleft-of-soft-and-hard-palate",
        "name": "Submucous cleft of soft and hard palate",
        "genes": 2,
        "url": "https://dantelabs.com/traits/submucous-cleft-of-soft-and-hard-palate"
      }
    ],
    "genes": [
      {
        "slug": "med16",
        "symbol": "MED16",
        "hgnc": "HGNC:17556",
        "name": "mediator complex subunit 16",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med16"
      },
      {
        "slug": "taf4",
        "symbol": "TAF4",
        "hgnc": "HGNC:11537",
        "name": "TATA-box binding protein associated factor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf4"
      },
      {
        "slug": "tbx5",
        "symbol": "TBX5",
        "hgnc": "HGNC:11604",
        "name": "T-box transcription factor 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx5"
      },
      {
        "slug": "tgfb3",
        "symbol": "TGFB3",
        "hgnc": "HGNC:11769",
        "name": "transforming growth factor beta 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfb3"
      },
      {
        "slug": "bub1",
        "symbol": "BUB1",
        "hgnc": "HGNC:1148",
        "name": "BUB1 mitotic checkpoint serine/threonine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bub1"
      },
      {
        "slug": "grhl3",
        "symbol": "GRHL3",
        "hgnc": "HGNC:25839",
        "name": "grainyhead like transcription factor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grhl3"
      },
      {
        "slug": "nxn",
        "symbol": "NXN",
        "hgnc": "HGNC:18008",
        "name": "nucleoredoxin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nxn"
      },
      {
        "slug": "ubb",
        "symbol": "UBB",
        "hgnc": "HGNC:12463",
        "name": "ubiquitin B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubb"
      },
      {
        "slug": "ada2",
        "symbol": "ADA2",
        "hgnc": "HGNC:1839",
        "name": "adenosine deaminase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ada2"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "ddx59",
        "symbol": "DDX59",
        "hgnc": "HGNC:25360",
        "name": "DEAD-box helicase 59",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddx59"
      },
      {
        "slug": "dvl1",
        "symbol": "DVL1",
        "hgnc": "HGNC:3084",
        "name": "dishevelled segment polarity protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dvl1"
      },
      {
        "slug": "fkbp14",
        "symbol": "FKBP14",
        "hgnc": "HGNC:18625",
        "name": "FKBP prolyl isomerase 14",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fkbp14"
      },
      {
        "slug": "gata1",
        "symbol": "GATA1",
        "hgnc": "HGNC:4170",
        "name": "GATA binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata1"
      },
      {
        "slug": "gnb2",
        "symbol": "GNB2",
        "hgnc": "HGNC:4398",
        "name": "G protein subunit beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnb2"
      },
      {
        "slug": "h4c5",
        "symbol": "H4C5",
        "hgnc": "HGNC:4790",
        "name": "H4 clustered histone 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h4c5"
      },
      {
        "slug": "heatr3",
        "symbol": "HEATR3",
        "hgnc": "HGNC:26087",
        "name": "HEAT repeat containing 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/heatr3"
      },
      {
        "slug": "ipo8",
        "symbol": "IPO8",
        "hgnc": "HGNC:9853",
        "name": "importin 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ipo8"
      },
      {
        "slug": "med12",
        "symbol": "MED12",
        "hgnc": "HGNC:11957",
        "name": "mediator complex subunit 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med12"
      },
      {
        "slug": "msx2",
        "symbol": "MSX2",
        "hgnc": "HGNC:7392",
        "name": "msh homeobox 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msx2"
      },
      {
        "slug": "rpl11",
        "symbol": "RPL11",
        "hgnc": "HGNC:10301",
        "name": "ribosomal protein L11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl11"
      },
      {
        "slug": "rpl15",
        "symbol": "RPL15",
        "hgnc": "HGNC:10306",
        "name": "ribosomal protein L15",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl15"
      },
      {
        "slug": "rpl18",
        "symbol": "RPL18",
        "hgnc": "HGNC:10310",
        "name": "ribosomal protein L18",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl18"
      },
      {
        "slug": "rpl26",
        "symbol": "RPL26",
        "hgnc": "HGNC:10327",
        "name": "ribosomal protein L26",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl26"
      },
      {
        "slug": "rpl27",
        "symbol": "RPL27",
        "hgnc": "HGNC:10328",
        "name": "ribosomal protein L27",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl27"
      },
      {
        "slug": "rpl31",
        "symbol": "RPL31",
        "hgnc": "HGNC:10334",
        "name": "ribosomal protein L31",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl31"
      },
      {
        "slug": "rpl35",
        "symbol": "RPL35",
        "hgnc": "HGNC:10344",
        "name": "ribosomal protein L35",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl35"
      },
      {
        "slug": "rpl35a",
        "symbol": "RPL35A",
        "hgnc": "HGNC:10345",
        "name": "ribosomal protein L35a",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl35a"
      },
      {
        "slug": "rpl5",
        "symbol": "RPL5",
        "hgnc": "HGNC:10360",
        "name": "ribosomal protein L5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl5"
      },
      {
        "slug": "rpl8",
        "symbol": "RPL8",
        "hgnc": "HGNC:10368",
        "name": "ribosomal protein L8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl8"
      },
      {
        "slug": "rpl9",
        "symbol": "RPL9",
        "hgnc": "HGNC:10369",
        "name": "ribosomal protein L9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl9"
      },
      {
        "slug": "rps10",
        "symbol": "RPS10",
        "hgnc": "HGNC:10383",
        "name": "ribosomal protein S10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps10"
      },
      {
        "slug": "rps15a",
        "symbol": "RPS15A",
        "hgnc": "HGNC:10389",
        "name": "ribosomal protein S15a",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps15a"
      },
      {
        "slug": "rps17",
        "symbol": "RPS17",
        "hgnc": "HGNC:10397",
        "name": "ribosomal protein S17",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps17"
      },
      {
        "slug": "rps19",
        "symbol": "RPS19",
        "hgnc": "HGNC:10402",
        "name": "ribosomal protein S19",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps19"
      },
      {
        "slug": "rps20",
        "symbol": "RPS20",
        "hgnc": "HGNC:10405",
        "name": "ribosomal protein S20",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps20"
      },
      {
        "slug": "rps24",
        "symbol": "RPS24",
        "hgnc": "HGNC:10411",
        "name": "ribosomal protein S24",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps24"
      },
      {
        "slug": "rps26",
        "symbol": "RPS26",
        "hgnc": "HGNC:10414",
        "name": "ribosomal protein S26",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps26"
      },
      {
        "slug": "rps27",
        "symbol": "RPS27",
        "hgnc": "HGNC:10416",
        "name": "ribosomal protein S27",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps27"
      },
      {
        "slug": "rps28",
        "symbol": "RPS28",
        "hgnc": "HGNC:10418",
        "name": "ribosomal protein S28",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps28"
      },
      {
        "slug": "rps29",
        "symbol": "RPS29",
        "hgnc": "HGNC:10419",
        "name": "ribosomal protein S29",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps29"
      },
      {
        "slug": "rps7",
        "symbol": "RPS7",
        "hgnc": "HGNC:10440",
        "name": "ribosomal protein S7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps7"
      },
      {
        "slug": "scnm1",
        "symbol": "SCNM1",
        "hgnc": "HGNC:23136",
        "name": "sodium channel modifier 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnm1"
      },
      {
        "slug": "sf3b4",
        "symbol": "SF3B4",
        "hgnc": "HGNC:10771",
        "name": "splicing factor 3b subunit 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sf3b4"
      },
      {
        "slug": "slc25a19",
        "symbol": "SLC25A19",
        "hgnc": "HGNC:14409",
        "name": "solute carrier family 25 member 19",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a19"
      },
      {
        "slug": "smarcd1",
        "symbol": "SMARCD1",
        "hgnc": "HGNC:11106",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit D1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcd1"
      },
      {
        "slug": "tsr2",
        "symbol": "TSR2",
        "hgnc": "HGNC:25455",
        "name": "TSR2 ribosome maturation factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsr2"
      },
      {
        "slug": "zpr1",
        "symbol": "ZPR1",
        "hgnc": "HGNC:13051",
        "name": "ZPR1 zinc finger",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zpr1"
      },
      {
        "slug": "dyrk1a",
        "symbol": "DYRK1A",
        "hgnc": "HGNC:3091",
        "name": "dual specificity tyrosine phosphorylation regulated kinase 1A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dyrk1a"
      },
      {
        "slug": "snrpb",
        "symbol": "SNRPB",
        "hgnc": "HGNC:11153",
        "name": "small nuclear ribonucleoprotein polypeptides B and B1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snrpb"
      },
      {
        "slug": "tcof1",
        "symbol": "TCOF1",
        "hgnc": "HGNC:11654",
        "name": "treacle ribosome biogenesis factor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcof1"
      }
    ]
  }
}