{
  "url": "https://dantelabs.com/traits/bladder-exstrophy",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "bladder-exstrophy",
    "id": "HP:0002836",
    "name": "Bladder exstrophy",
    "definition": "Eversion of the posterior bladder wall through the congenitally absent lower anterior abdominal wall and anterior bladder wall.",
    "synonyms": [
      "Ectopia vesicae"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-bladder-morphology",
        "name": "Abnormal bladder morphology",
        "url": "https://dantelabs.com/traits/abnormal-bladder-morphology"
      },
      {
        "slug": "exstrophy",
        "name": "Exstrophy",
        "url": "https://dantelabs.com/traits/exstrophy"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "isl1",
        "symbol": "ISL1",
        "hgnc": "HGNC:6132",
        "name": "ISL LIM homeobox 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/isl1"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp63"
      },
      {
        "slug": "med12",
        "symbol": "MED12",
        "hgnc": "HGNC:11957",
        "name": "mediator complex subunit 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med12"
      },
      {
        "slug": "cdh11",
        "symbol": "CDH11",
        "hgnc": "HGNC:1750",
        "name": "cadherin 11",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdh11"
      },
      {
        "slug": "pah",
        "symbol": "PAH",
        "hgnc": "HGNC:8582",
        "name": "phenylalanine hydroxylase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pah"
      },
      {
        "slug": "kras",
        "symbol": "KRAS",
        "hgnc": "HGNC:6407",
        "name": "KRas proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kras"
      },
      {
        "slug": "upb1",
        "symbol": "UPB1",
        "hgnc": "HGNC:16297",
        "name": "beta-ureidopropionase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/upb1"
      }
    ]
  }
}