{
  "url": "https://dantelabs.com/traits/bifid-nose",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "bifid-nose",
    "id": "HP:0011803",
    "name": "Cleft nasal bridge",
    "label": "Bifid nose",
    "definition": "Visually assessable vertical indentation, cleft, or depression of the nasal bridge, ridge and tip.",
    "synonyms": [
      "Cleft nose",
      "Indentation or clefting of the nose",
      "Indented bridge of nose",
      "Bifid nasal bridge"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "midline-defect-of-the-nose",
        "name": "Midline defect of the nose",
        "url": "https://dantelabs.com/traits/midline-defect-of-the-nose"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "frem1",
        "symbol": "FREM1",
        "hgnc": "HGNC:23399",
        "name": "FRAS1 related extracellular matrix 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/frem1"
      },
      {
        "slug": "alx4",
        "symbol": "ALX4",
        "hgnc": "HGNC:450",
        "name": "ALX homeobox 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alx4"
      },
      {
        "slug": "zswim6",
        "symbol": "ZSWIM6",
        "hgnc": "HGNC:29316",
        "name": "zinc finger SWIM-type containing 6",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/zswim6"
      },
      {
        "slug": "alx1",
        "symbol": "ALX1",
        "hgnc": "HGNC:1494",
        "name": "ALX homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alx1"
      },
      {
        "slug": "nsmf",
        "symbol": "NSMF",
        "hgnc": "HGNC:29843",
        "name": "NMDA receptor synaptonuclear signaling and neuronal migration factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsmf"
      },
      {
        "slug": "nuak2",
        "symbol": "NUAK2",
        "hgnc": "HGNC:29558",
        "name": "NUAK family kinase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nuak2"
      },
      {
        "slug": "nf1",
        "symbol": "NF1",
        "hgnc": "HGNC:7765",
        "name": "neurofibromin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf1"
      },
      {
        "slug": "ptch1",
        "symbol": "PTCH1",
        "hgnc": "HGNC:9585",
        "name": "patched 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptch1"
      },
      {
        "slug": "tbx4",
        "symbol": "TBX4",
        "hgnc": "HGNC:11603",
        "name": "T-box transcription factor 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx4"
      },
      {
        "slug": "tfe3",
        "symbol": "TFE3",
        "hgnc": "HGNC:11752",
        "name": "transcription factor binding to IGHM enhancer 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tfe3"
      },
      {
        "slug": "alx3",
        "symbol": "ALX3",
        "hgnc": "HGNC:449",
        "name": "ALX homeobox 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alx3"
      },
      {
        "slug": "hyls1",
        "symbol": "HYLS1",
        "hgnc": "HGNC:26558",
        "name": "HYLS1 centriolar and ciliogenesis associated",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hyls1"
      }
    ]
  }
}